TEM8/ANTXR1 Antibody [PE/Cy7]

• Reactivity: Hu, Mu, Rt
• Applications: Flow
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: PE/Cy7
• Concentration: 1 mg/ml

TEM8/ANTXR1 Antibody [PE/Cy7] Summary

• Immunogen: Antibody was raised against a peptide corresponding to 13 amino acids near the center of human ATR. The immunogen is located within amino acids 220 - 270 of ATR. Amino Acid Squence: RGNGFRHARNVDR
• Specificity: Recognizes all three isoforms of ATR.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ANTXR1
• Purity: Ion exchange chromatography

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
• Theoretical MW: 45 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control:

  MYF6 Antibody (1H3) - Azide and BSA Free
  STIM1 Antibody [DyLight 550]

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Ion exchange chromatography

Alternate Names for TEM8/ANTXR1 Antibody [PE/Cy7]

• anthrax toxin receptor 1
• ANTXR1
• ATR2310008J16Rik
• FLJ10601
• FLJ11298
• FLJ21776
• TEM8
• TEM82810405N18Rik
• Tumor endothelial marker 8

Background

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ANTXR1