TEM8/ANTXR1 Products

Antibodies
TEM8/ANTXR1 Antibody [Unconju ...
TEM8/ANTXR1 Antibody [Unconjugated]
AF3886
Species: Hu
Applications: WB, IHC, ICC/IF
Host: Goat Polyclonal
Formulation Catalog # Availability Price  
TEM8/ANTXR1 Antibody
TEM8/ANTXR1 Antibody
NBP1-77233
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
TEM8/ANTXR1 Knockout HeLa Cel ...
TEM8/ANTXR1 Knockout HeLa Cell Lysate
NBP2-77332
Species: Hu
Applications: WB
TEM8/ANTXR1 Overexpression Ly ...
TEM8/ANTXR1 Overexpression Lysate
NBP2-06060
Species: Hu
Applications: WB
TEM8/ANTXR1 Overexpression Ly ...
TEM8/ANTXR1 Overexpression Lysate
NBP2-05826
Species: Hu
Applications: WB
Proteins
Recombinant Mouse TEM8/ANTXR1 ...
Recombinant Mouse TEM8/ANTXR1 Fc C...
10202-AR
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human TEM8/ANTXR1 ...
Recombinant Human TEM8/ANTXR1 His-...
3886-AR
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human TEM8/ANTXR1 ...
Recombinant Human TEM8/ANTXR1 Protein
H00084168-P01
Species: Hu
Applications: WB, ELISA, PA, AP

Description

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 84168
Alternate Names
  • FLJ21776
  • FLJ11298
  • FLJ10601
  • TEM82810405N18Rik
  • ATR2310008J16Rik
  • Tumor endothelial marker 8
  • anthrax toxin receptor 1

Research Areas for TEM8/ANTXR1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cellular Markers
Extracellular Matrix
Phospho-Specific

PTMs for TEM8/ANTXR1

Learn more about PTMs related to TEM8/ANTXR1.

Cleavage
Phosphorylation
Biotinylation
Reduction
Ubiquitination

Bioinformatics Tool for TEM8/ANTXR1

Discover related pathways, diseases and genes to TEM8/ANTXR1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.