TEM8/ANTXR1 Products

Description

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.

Bioinformatics

Entrez	362393 Rat 69538 Mouse 84168 Human
Uniprot	NP_115584 Human NP_115584. Human NP_115584.1 Human NP_444262 Human NP_444262.1 Human Q9H6X2 Human
Product By Gene ID	84168
Alternate Names	anthrax toxin receptor 1 ATR2310008J16Rik FLJ10601 FLJ11298 FLJ21776 TEM82810405N18Rik Tumor endothelial marker 8

Research Areas for TEM8/ANTXR1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cellular Markers
Extracellular Matrix
Phospho-Specific