TEM8/ANTXR1 Products

Antibodies
TEM8/ANTXR1 Antibody
TEM8/ANTXR1 Antibody
AF3886
Species: Hu
Applications: WB, IHC, ICC
Host: Goat Polyclonal
TEM8/ANTXR1 Antibody
TEM8/ANTXR1 Antibody
NBP1-77233
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, ICC, IF
Host: Rabbit Polyclonal
Lysates
TEM8/ANTXR1 Overexpression Ly ...
TEM8/ANTXR1 Overexpression Lysate ...
NBP2-05826
Applications: WB
TEM8/ANTXR1 Overexpression Ly ...
TEM8/ANTXR1 Overexpression Lysate ...
NBP2-06060
Applications: WB
TEM8/ANTXR1 Overexpression Ly ...
TEM8/ANTXR1 Overexpression Lysate ...
NBL1-07554
Applications: WB
Proteins
TEM8/ANTXR1 Recombinant Prote ...
TEM8/ANTXR1 Recombinant Protein
H00084168-P01
Species: Hu
Applications: WB, ELISA, PA
TEM8/ANTXR1 Partial Recombina ...
TEM8/ANTXR1 Partial Recombinant Pr...
H00084168-Q01
Species: Hu
Applications: WB, ELISA, PA
TEM8/ANTXR1 Recombinant Prote ...
TEM8/ANTXR1 Recombinant Protein An...
NBP2-33636PEP
Species: Hu
Applications: AC
RNAi
TEM8/ANTXR1 RNAi
TEM8/ANTXR1 RNAi
H00084168-R06
Species: Hu
Applications: RNAi, RNAi SP
TEM8/ANTXR1 RNAi
TEM8/ANTXR1 RNAi
H00084168-R05
Species: Hu
Applications: RNAi, RNAi SP
TEM8/ANTXR1 RNAi
TEM8/ANTXR1 RNAi
H00084168-R04
Species: Hu
Applications: RNAi, RNAi SP

Description

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 84168
Alternate Names
  • FLJ21776
  • FLJ11298
  • FLJ10601
  • TEM82810405N18Rik
  • ATR2310008J16Rik
  • Tumor endothelial marker 8
  • anthrax toxin receptor 1

Research Areas for TEM8/ANTXR1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cellular Markers
Extracellular Matrix
Phospho-Specific

PTMs for TEM8/ANTXR1

Learn more about PTMs related to TEM8/ANTXR1.

Cleavage
Phosphorylation
Biotinylation
Reduction
Ubiquitination

Bioinformatics Tool for TEM8/ANTXR1

Discover related pathways, diseases and genes to TEM8/ANTXR1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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