Western Blot: TEM7/PLXDC1 Antibody (197C193 (IM193)) [NB100-56557] - Analysis of human breast cancer lysate (35 ug per lane, RIPA buffer) at 0.03ug/ml. Band observed at ~60kDa. (Expected MW of 55.8kDa according to ...read more
Immunohistochemistry: TEM7/PLXDC1 Antibody (197C193 (IM193)) [NB100-56557] - Staining of Tumor Endothelial Marker 7 in formalin-fixed, paraffin-embedded human Purkinje neurons at 2.5 ug/ml. Hematoxylin-eosin ...read more
Western Blot: TEM7/PLXDC1 Antibody (197C193 (IM193)) [NB100-56557] - Detection of TEM7 with TEM7 antibody. Human HCT-116 cell lysate probed with TEM7 antibody at 1 ug/ml.
Immunohistochemistry-Paraffin: TEM7/PLXDC1 Antibody (197C193 (IM193)) [NB100-56557] - Formalin-fixed, paraffin-embedded human breast vessel stained with TEM7 antibody at 5 ug/ml.
Immunocytochemistry/Immunofluorescence: see Meng et al, 2007. Immunohistochemistry (frozen): see Lee et al, 2006. Immunohistochemistry (paraffin): 2-5 ug/ml; see Nanda et al, 2004 and Lee et al, 2005. Immunoprecipitation: see Nanda et al, 2004.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS containing 0.05% BSA
0.05% Sodium Azide
Protein G purified
Alternate Names for TEM7/PLXDC1 Antibody (197C193 (IM193))
plexin domain containing 1,2410003I07Rik
plexin domain-containing protein 1
Tumor endothelial marker 3
Tumor endothelial marker 7
Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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