TEM7/PLXDC1 Antibody (197C193 (IM193))


Western Blot: TEM7/PLXDC1 Antibody (197C193 (IM193)) [NB100-56557] - Analysis of human breast cancer lysate (35 ug per lane, RIPA buffer) using TEM7 antibody (NB100-56557) at 0.03ug/ml. Band observed at ~60kDa. ...read more
Immunohistochemistry-Paraffin: TEM7/PLXDC1 Antibody (197C193 (IM193)) [NB100-56557] - Formalin-fixed, paraffin-embedded human breast vessel stained with TEM7 antibody at 5 ug/ml.
Western Blot: TEM7/PLXDC1 Antibody (197C193 (IM193)) [NB100-56557] - Detection of TEM7 with TEM7 antibody. Human HCT-116 cell lysate probed with TEM7 antibody at 1 ug/ml.
Immunohistochemistry: TEM7/PLXDC1 Antibody (197C193 (IM193)) [NB100-56557] - Staining of Tumor Endothelial Marker 7 in formalin-fixed, paraffin-embedded human Purkinje neurons at 2.5 ug/ml. Hematoxylin-eosin ...read more

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr, IHC-P, IP
197C193 (IM193)
0.5 mg/ml

TEM7/PLXDC1 Antibody (197C193 (IM193)) Summary

Amino acids 409-425 (LQNNLSPKTKGTPVHLG) of human TEM7 were used to develop this monoclonal antibody.
Protein G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS containing 0.05% BSA
0.05% Sodium Azide
0.5 mg/ml
Protein G purified


Application Notes
Immunocytochemistry/Immunofluorescence: see Meng et al, 2007. Immunohistochemistry (frozen): see Lee et al, 2006. Immunohistochemistry (paraffin): 2-5 ug/ml; see Nanda et al, 2004 and Lee et al, 2005. Immunoprecipitation: see Nanda et al, 2004.
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NB100-56557 in the following applications:

Reactivity Notes

Cross reacts with Human, Mouse and Rat.

Alternate Names for TEM7/PLXDC1 Antibody (197C193 (IM193))

  • FLJ45632
  • plexin domain containing 1,2410003I07Rik
  • plexin domain-containing protein 1
  • PLXDC1
  • TEM3
  • TEM3FLJ36270
  • TEM7DKFZp686F0937
  • Tumor endothelial marker 3
  • Tumor endothelial marker 7


Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TEM7/PLXDC1 Antibody (NB100-56557)(8)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: ICC/IF, IHC, IHC-Fr, IHC-P, WB.

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Showing Publications 1 - 8 of 8.
Publications using NB100-56557 Applications Species
Carpenter RL, Paw I, Zhu H et al. The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis. Oncotarget 2015 Sep 8 [PMID:26093087] (IHC) IHC
Mehran R, Nilsson M, Khajavi M et al. Tumor endothelial markers define novel subsets of cancer-specific circulating endothelial cells associated with antitumor efficacy. Cancer Res. 2014 Mar 13 [PMID:24626092] (IHC-Fr, Mouse, Human) IHC-Fr Mouse, Human
Yamaji Y, Yoshida S, Ishikawa K et al. TEM7 (PLXDC1) in neovascular endothelial cells of fibrovascular membranes from patients with proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci. 2008 Jul [PMID:18316703] (IHC-P, Human) IHC-P Human
Fuchs Bruno, Mahlum Eric, Halder Chandralekha et al. High expression of tumor endothelial marker 7 is associated with metastasis and poor survival of patients with osteogenic sarcoma. Gene. 2007 Sep 15 [PMID:17560052] (Human) Human
Meng F, Henson R, Patel T. Chemotherapeutic stress selectively activates NF-kappa B-dependent AKT and VEGF expression in liver cancer-derived endothelial cells. Am J Physiol Cell Physiol. 2007 Aug [PMID:17537803] (WB, ICC/IF) WB, ICC/IF
Lee HK, Kang DS, Seo IA et al. Expression of tumor endothelial marker 7 mRNA and protein in the dorsal root ganglion neurons of the rat. Neurosci Lett. 2006 Jul 10 [PMID:16707219] (IHC-Fr) IHC-Fr
Lee HK, Bae HR, Park HK et al. Cloning, characterization and neuronal expression profiles of tumor endothelial marker 7 in the rat brain. Brain Res Mol Brain Res. 2005 May 20 [PMID:15893603] (IHC-P) IHC-P
Nanda A, Buckhaults P, Seaman S et al. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. Cancer Res. 2004 Dec 1 [PMID:15574754] (WB, Human) WB Human

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for TEM7/PLXDC1 Antibody (NB100-56557) (0)

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB100-56557AF405
Alexa Fluor (R) 488 Labeled NB100-56557AF488
Alexa Fluor (R) 647 Labeled NB100-56557AF647
Alexa Fluor (R) 700 Labeled NB100-56557AF700
Allophycocyanin Labeled NB100-56557APC
Biotin Labeled NB100-56557B
DyLight 350 Labeled NB100-56557UV
DyLight 405 Labeled NB100-56557V
DyLight 405LS Labeled NB100-56557V3
DyLight 488 Labeled NB100-56557G
DyLight 550 Labeled NB100-56557R
DyLight 650 Labeled NB100-56557C
DyLight 680 Labeled NB100-56557FR
DyLight 755 Labeled NB100-56557IR
HRP Labeled NB100-56557H
PE Labeled NB100-56557PE
PerCP Labeled NB100-56557PCP

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Gene Symbol PLXDC1

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