TEM7/PLXDC1 Products

Description

Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.

Bioinformatics

Entrez	57125 Human
Uniprot	AAG00869 Human AAH36059.1 Human NM_020405 Human NP_065138 Human Q8IUK5 Human
Product By Gene ID	57125
Alternate Names	FLJ45632 plexin domain containing 1,2410003I07Rik plexin domain-containing protein 1 TEM3FLJ36270 TEM7DKFZp686F0937 Tumor endothelial marker 3 Tumor endothelial marker 7

Research Areas for TEM7/PLXDC1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis