STAM-1 Antibody (29C678)

Images

 
Western Blot: STAM-1 Antibody (29C678) [NB100-56533] - Western blot analysis of HeLa lysate (35ug per lane, RIPA buffer) using STAM antibody (NB100-56533) at 1ug/ml. Band observed at ~65kDA. (Expected MW of 59.2kDa ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
29C678
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.5 mg/ml

STAM-1 Antibody (29C678) Summary

Immunogen
This antibody was developed against a synthetic peptide corresponding to amino acids 149-165 of human STAM.
Specificity
A 59 kDa band is observed.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
STAM
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
Positive Control
293 Lysate (NB800-PC6)
HeLa Lysate (NB800-PC1)

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for STAM-1 Antibody (29C678)

  • DKFZp686J2352
  • HSE1 Homolog
  • signal transducing adapter molecule 1
  • signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
  • STAM
  • STAM1
  • STAM-1
  • STAM1STAM-1

Background

STAM is a signal transducing adaptor molecule, that contains an Src homology 3 (SH3) domain and immunoreceptor tyrosine-based activation motif (ITAM). STAM is associated with Jak3 and Jak2 tyrosine kinases via its ITAM region and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF, respectively. An SH3 deletion mutant of STAM confers a dominant-negative effect on DNA synthesis mediated by IL-2 and GM-CSF. Furthermore, the wild-type STAM, but not STAM mutants deleted of SH3 and ITAM, significantly enhances c-myc induction mediated by IL-2 and GM-CSF. These results strongly implicate STAM in the signaling pathways for cell growth and c-myc induction immediately downstream of the Jaks associated with the cytokine receptors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for STAM-1 Antibody (NB100-56533) (0)

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB100-56533AF405
Alexa Fluor 488 Labeled NB100-56533AF488
Alexa Fluor 647 Labeled NB100-56533AF647
Alexa Fluor 700 Labeled NB100-56533AF700
Biotin Labeled NB100-56533B
DyLight 350 Labeled NB100-56533UV
DyLight 405 Labeled NB100-56533V
DyLight 488 Labeled NB100-56533G
DyLight 550 Labeled NB100-56533R
DyLight 650 Labeled NB100-56533C
DyLight 680 Labeled NB100-56533FR
DyLight 755 Labeled NB100-56533IR
HRP Labeled NB100-56533H

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Diseases for STAM-1 Antibody (NB100-56533)

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Bioinformatics

Gene Symbol STAM
Entrez
Uniprot