SREBP1 Antibody (2A4) [HRP]


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Product Details

Reactivity Hu, Mu, Rt, Ca, Ch, SyHa, HaSpecies Glossary
Applications WB
Please see the vial label for concentration. If unlisted please contact technical services.

SREBP1 Antibody (2A4) [HRP] Summary

6 His-tag fusion protein of human SREBP1 corresponding to amino acids 301-407. [UniProt# P36956]
Cytoplasmic and nuclear
IgG1 Kappa
Protein G purified
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Packaging, Storage & Formulations

Store at 4C in the dark.
No Preservative
Please see the vial label for concentration. If unlisted please contact technical services.
Protein G purified


  • Western Blot 1-2ug/ml
Application Notes
This SREBP1 (clone 2A4) antibody is useful for Western blot where a band can be seen at 125 kDa (precursor) and additional bands may be seen at 60-70 kDa (cleaved).
Readout System

Reactivity Notes

Human, mouse, rat and Golden Syrian Hamster. Canine reactivity reported in scientific literature (PMID: 23720350).Hamster reactivity reported in scientific literature (PMID: 24393244). Chicken reactivity reported in multiple pieces scientific literature

Alternate Names for SREBP1 Antibody (2A4) [HRP]

  • BHLHD1
  • Class D basic helix-loop-helix protein 1
  • SREBP 1c
  • SREBP-1
  • sterol regulatory element binding protein-1
  • sterol regulatory element binding transcription factor 1
  • sterol regulatory element-binding protein 1
  • Sterol regulatory element-binding transcription factor 1


The importance of lipids for survival is underscored when starvation occurs - cellular responses occur in major organ pathways to protect against detrimental loss of lipids. For example, lipid generation and stabilization occurs in the brain even when serious deficiencies of dietary lipid exist. Embryonic and fetal tissues also are spared the effects of lacking lipids, even at the expense of maternal health. In all of these examples, the transcription factor Sterol-Regulatory Element-Binding Protein 1 (SREBP1) is a critical contributor to effective cholesterol and fatty acid synthesis, through the PPAR-gamma and AMPK signaling pathways. During fasting and starvation, more than 40% of transcription factors in an individual are dedicated to adipogenesis. However, in certain conditions that lead to obesity, the SREBP1 transcription activity is overstimulated by elevated cofactor expression (as in the case of resistin) and the result is erroneous de novo lipogenesis in hepatocytes and plasma. Excessive lipogenesis in these tissues is then associated with dyslipidemia, atherosclerosis and abnormal HDL/LDL/VLDL ratios and commonly attributed obesity-related disease.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for SREBP1 Antibody (NB600-582H) (0)

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Secondary Antibodies


Isotype Controls

Other Available Formats

Biotin Labeled NB600-582B
DyLight 405 Labeled NB600-582V
DyLight 488 Labeled NB600-582G
DyLight 550 Labeled NB600-582R
DyLight 650 Labeled NB600-582C
FITC Labeled NB600-582F

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Blogs on SREBP1.

SREBP2 - regulating cholesterol homeostasis and lipid metabolism
Sterol regulatory element-binding proteins (SREBP) are important transcription factors regulating the synthesis and uptake of lipids including cholesterol. This essential role in lipid metabolism makes investigations into the functions SREBPs im...  Read full blog post.

SREBP: Gatekeeper of Cholesterol Homeostasis
SREBP1 (sterol-regulatory-element-binding protein 2) is a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. It regulates sterol and cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g....  Read full blog post.

Contact Information

Product PDFs


Gene Symbol SREBF1

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