SREBP1 Products

SREBP1 Assay Kit (Colorimetri ...
SREBP1 Assay Kit (Colorimetric)
Applications: Func
SREBP1 Knockout HeLa Cell Lys ...
SREBP1 Knockout HeLa Cell Lysate
Species: Hu
SREBP1 Overexpression Lysate
SREBP1 Overexpression Lysate
Species: Hu
Applications: WB
SREBP1 Overexpression Lysate
SREBP1 Overexpression Lysate
Species: Hu
Applications: WB
SREBP1 Blocking Peptide
SREBP1 Blocking Peptide
Species: Hu
SREBP1 Blocking Peptide
SREBP1 Blocking Peptide
Species: Hu
Recombinant Human SREBP1 Prot ...
Recombinant Human SREBP1 Protein
Species: Hu
Applications: WB, ELISA, PA, AP


SREBP (Sterol Regulatory Element Binding Protein) 1 and 2 are transcription factors which participate in the control of cholesterol homeostasis. SREBP proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. SREBPs may also play some role in the apoptotic processes.

SREBP1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.


Entrez Human
Uniprot Human
Product By Gene ID 6720
Alternate Names
  • SREBP 1c
  • SREBP-1
  • BHLHD1
  • Sterol regulatory element-binding transcription factor 1
  • sterol regulatory element-binding protein 1
  • Class D basic helix-loop-helix protein 1
  • sterol regulatory element binding protein-1
  • sterol regulatory element binding transcription factor 1

Research Areas for SREBP1

Find related products by research area and learn more about each of the different research areas below.

Cholesterol Metabolism
Chromatin Research
Diabetes Research
Lipid and Metabolism
Transcription Factors and Regulators

Bioinformatics Tool for SREBP1

Discover related pathways, diseases and genes to SREBP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related SREBP1 Blog Posts

Check out the latest blog posts on SREBP1.
SREBP2 - regulating cholesterol homeostasis and lipid metabolism
Sterol regulatory element-binding proteins (SREBP) are important transcription factors regulating the synthesis and uptake of lipids including cholesterol. This essential role in lipid metabolism makes investigations into the functions SREBPs im...    Read more.
SREBP: Gatekeeper of Cholesterol Homeostasis
SREBP1 (sterol-regulatory-element-binding protein 2) is a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. It regulates sterol and cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g....    Read more.
Read more SREBP1 related blogs.