SOX10 Antibody (SOX10/991) [DyLight 680]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, IHC-P
Clone
SOX10/991
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 680

Order Details

SOX10 Antibody (SOX10/991) [DyLight 680] Summary

Immunogen
Recombinant human SOX10 protein fragment (around aa115-269) (exact sequence is proprietar
Localization
Nuclear
Marker
Melanoma Marker
Specificity
The specificity of this monoclonal antibody to human, mouse SOX10 was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of ~55kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG -box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
SOX10
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SOX10 Antibody (SOX10/991) [DyLight 680]

  • DOM
  • MGC15649
  • PCWH
  • SOX10
  • SRY (sex determining region Y)-box 10
  • SRY-related HMG-box gene 10
  • transcription factor SOX-10
  • WS4
  • WS4C
  • WS4mouse, human homolog of

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for SOX10 Antibody (NBP2-59621FR) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-59621AF350
Alexa Fluor 405 NBP2-59621AF405
Alexa Fluor 488 NBP2-59621AF488
Alexa Fluor 532 NBP2-59621AF532
Alexa Fluor 594 NBP2-59621AF594
Alexa Fluor 647 NBP2-59621AF647
Alexa Fluor 700 NBP2-59621AF700
Alexa Fluor 750 NBP2-59621AF750
Allophycocyanin NBP2-59621APC
Allophycocyanin/Cy7 NBP2-59621APCCY7
Biotin NBP2-59621B
DyLight 350 NBP2-59621UV
DyLight 405 NBP2-59621V
DyLight 488 NBP2-59621G
DyLight 550 NBP2-59621R
DyLight 594 NBP2-59621DL594
DyLight 650 NBP2-59621C
DyLight 680 NBP2-59621FR
DyLight 755 NBP2-59621IR
FITC NBP2-59621F
HRP NBP2-59621H
Janelia Fluor 549 NBP2-59621JF549
Janelia Fluor 646 NBP2-59621JF646
PE NBP2-59621PE
PE/Atto594 NBP2-59621PEATT594
PE/Cy5.5 NBP2-59621PECY55
PE/Cy7 NBP2-59621PECY7
PerCP NBP2-59621PCP

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Bioinformatics Tool for SOX10 Antibody (NBP2-59621FR)

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Bioinformatics

Gene Symbol SOX10