SOX10 Products

Description

SOX (SRY related HMG box) is a family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. All SOX proteins have a single HMG box and bind linear DNA in a sequence specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse (Collignon et al., 1996). These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution. The SOX10 protein may act as a transcriptional activator after forming a protein complex with other proteins. It acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg Shah and Waardenburg Hirschsprung disease. SOX10 is expressed in multipotent neural crest stem cells, and its expression is downregulated upon their differentiation (Kim et al, 2003)

Bioinformatics

Entrez	29361 Rat
Product By Gene ID	6663
Alternate Names	DOM MGC15649 PCWH SOX10 SOX-10 SRY (sex determining region Y)-box 10 SRY-related HMG-box gene 10 transcription factor SOX-10 WS2E WS4 WS4C WS4mouse, human homolog of