SOX10 Antibody (SOX10/991) [Alexa Fluor® 532]


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Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, Flow, Flow-IC, ICC/IF, IHC, IHC-P
Alexa Fluor 532

Order Details

SOX10 Antibody (SOX10/991) [Alexa Fluor® 532] Summary

Recombinant human SOX10 protein fragment (around aa115-269) (exact sequence is proprietar
Melanoma Marker
The specificity of this monoclonal antibody to human, mouse SOX10 was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of ~55kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG -box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells
IgG2b Kappa
Protein A or G purified
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  • Western Blot
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Flow (Intracellular)
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Protein A or G purified


Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SOX10 Antibody (SOX10/991) [Alexa Fluor® 532]

  • DOM
  • MGC15649
  • PCWH
  • SOX10
  • SRY (sex determining region Y)-box 10
  • SRY-related HMG-box gene 10
  • transcription factor SOX-10
  • WS4
  • WS4C
  • WS4mouse, human homolog of


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-59621AF350
Alexa Fluor 405 NBP2-59621AF405
Alexa Fluor 488 NBP2-59621AF488
Alexa Fluor 532 NBP2-59621AF532
Alexa Fluor 594 NBP2-59621AF594
Alexa Fluor 647 NBP2-59621AF647
Alexa Fluor 700 NBP2-59621AF700
Alexa Fluor 750 NBP2-59621AF750
Allophycocyanin NBP2-59621APC
Biotin NBP2-59621B
DyLight 350 NBP2-59621UV
DyLight 405 NBP2-59621V
DyLight 488 NBP2-59621G
DyLight 550 NBP2-59621R
DyLight 594 NBP2-59621DL594
DyLight 650 NBP2-59621C
DyLight 680 NBP2-59621FR
DyLight 755 NBP2-59621IR
FITC NBP2-59621F
HRP NBP2-59621H
Janelia Fluor 549 NBP2-59621JF549
Janelia Fluor 646 NBP2-59621JF646
PE NBP2-59621PE
PerCP NBP2-59621PCP

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Gene Symbol SOX10