EDNRB/Endothelin R Type B Antibody

Images

 
Immunohistochemistry-Paraffin: EDNRB/Endothelin R Type B Antibody [NLS54] - Human Lung, Small Cell Carcinoma of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunohistochemistry-Paraffin: EDNRB/Endothelin R Type B Antibody [NLS54] - Analysis of anti-EDNRB / Endothelin B Receptor antibody with adrenal, medulla at 4 ug/ ml.
Immunohistochemistry-Paraffin: EDNRB/Endothelin R Type B Antibody [NLS54] - Analysis of anti-EDNRB / Endothelin B Receptor antibody with cells expressing vector only using this antibody at 4 ug/ ml.
Immunohistochemistry-Paraffin: EDNRB/Endothelin R Type B Antibody [NLS54] - Analysis of anti-EDNRB / Endothelin B Receptor antibody with transfected cells expressing Endothelin B Receptor at 4 ug/ ml.
Immunohistochemistry-Paraffin: EDNRB/Endothelin R Type B Antibody [NLS54] - Analysis of anti-EDNRB / Endothelin B Receptor antibody with human colon, carcinoma.

Product Details

Summary
Reactivity Hu, Ca, PmSpecies Glossary
Applications WB, IHC-P, ICC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

EDNRB/Endothelin R Type B Antibody Summary

Immunogen
Synthetic 19 amino acid peptide from N-terminal extracellular domain of human EDNRB.
Localization
Multi-pass membrane protein
Specificity
Human EDNRB. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PTPN5 (68%).
Predicted Species
Primate (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
EDNRB
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 4-11 ug/ml
  • Immunohistochemistry-Paraffin 4-11 ug/ml
  • Immunocytochemistry 1:10 - 1:500
Publications
Read Publications using
NLS54 in the following applications:

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (95%), Gibbon (95%), Monkey (89%), Marmoset (84%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for EDNRB/Endothelin R Type B Antibody

  • ABCDS
  • EDNRB
  • endothelin B receptor
  • Endothelin receptor non-selective type
  • endothelin receptor type B
  • ETB
  • ET-B
  • ETBR
  • ET-BR
  • ETRB
  • HSCR
  • HSCR2
  • WS4A

Background

The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct. The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel. ESTs have been isolated from amnion, B-cell/lung/testis, breast, brain, colon, ear, embryo, eye, heart, kidney, liver, liver/spleen, lung, lymph node, placenta, prostate, and skin libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for EDNRB/Endothelin R Type B Antibody (NLS54)(2)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ICC/IF.


Filter By Application
ICC/IF
(1)
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Mouse
(1)
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Video Protocols

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Bioinformatics

Gene Symbol EDNRB
Entrez
Uniprot