SLC31A1/CTR1 Antibody


Immunocytochemistry/ Immunofluorescence: SLC31A1/CTR1 Antibody [NB100-402] - CTR1 antibody was tested in NIH-3T3 cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and DyLight more
Immunohistochemistry: SLC31A1/CTR1 Antibody [NB100-402] - Panel 1: human CTR1 staining of breast cancer tissue. Panel 2: human CTR1-antigen competition in breast cancer tissue.
Immunohistochemistry: SLC31A1/CTR1 Antibody [NB100-402] - Left panel: Antibody staining of hCTR1 overexpressing cell line. Right panel: Antibody plus peptide competition staining.

Product Details

Reactivity Hu, Mu, Rt, Po, Ca, Xp, ZeSpecies Glossary
Applications WB, ICC/IF, IHC
1 mg/ml

SLC31A1/CTR1 Antibody Summary

A synthetic peptide derived from a C-terminal sequence of human SLC31A1/CTR1 [Uniprot: O15431]
Cell Membrane
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Immunocytochemistry/Immunofluorescence 1:500
  • Immunohistochemistry 1:250
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 1:250
  • Western Blot
Control Peptide
SLC31A1/CTR1 Peptide (NB100-402PEP)
Read Publications using
NB100-402 in the following applications:

Reactivity Notes

Canine reactivity reported in scientific literature (PMID: 29901089).

Packaging, Storage & Formulations

Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
1 mg/ml
Immunogen affinity purified

Alternate Names for SLC31A1/CTR1 Antibody

  • Copper transporter 1
  • COPT1
  • COPT1high affinity copper uptake protein 1
  • CTR1
  • CTR1MGC75487
  • HCTR1
  • hCTR1copper transport 1 homolog
  • SLC31A1
  • solute carrier family 31 (copper transporters), member 1
  • Solute carrier family 31 member 1


SLC31A1/CTR1 (solute carrier family 31 member 1/copper transporter 1) is a homotrimeric high-affinity, saturable copper importer implicated in dietary copper uptake. Homeostasis of copper is tightly controlled by inter-regulatory circuitry containing copper, Sp1, and CTR1, wherein Sp1 transcription factor acts as a copper sensor in modulating CTR1 expression which in turn controls cellular copper and Sp1 levels in a 3-way mutual regulatory loop. CTR1 mediated copper uptake is time, temperature, and pH dependent and specific for reduced form of Cu (I) and copper reduction has been proposed to be caused by Steap protein family or Dcytb protein (Cybrd1) both of which are reported to possess cupric reductase activity. The intracellular localization of CTR1 is variable in different cell lines: CTR1 is localized at the plasma membrane in HEK293, CaCo-2, and A2780 cells, whereas, in other cells such as HeLa, it is predominantly localized to vesicular compartments, and variability in trafficking rates between vesicular and plasma membrane compartments has been suggested as the cause of this differential localization. Post-translational O-linked glycosylation of CTR1 protects it against proteolytic cleavage of N terminal 17-kD fragment and the biological function of this cleaved variant or protease responsible is largely unknown. Selective knockout of Ctr1 in murine intestinal epithelial cells results in severe systemic copper deficiency, ataxia, and death prior to weaning.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Applications: IHC, IHC-P, WB
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Applications: ELISA, Flow, ICC/IF, IHC, IHC-P, WB
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Applications: ELISA, IHC, IHC-P, S-ELISA, WB
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Applications: CyTOF-ready, Dual ISH-IHC, ICC, IHC, ICFlow, Simple Western, WB
Species: Hu, Mu, Rt, Po, Ca, Xp, Ze
Applications: WB, ICC/IF, IHC

Publications for SLC31A1/CTR1 Antibody (NB100-402)(30)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Canine.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC-Fr, IHC-P, WB.

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Showing Publications 1 - 10 of 30. Show All 30 Publications.
Publications using NB100-402 Applications Species
Zhang X, Jiang Q, Su Y et al. AMPK phosphorylates and stabilises copper transporter 1 to synergise metformin and copper chelator for breast cancer therapy British journal of cancer 2023-02-17 [PMID: 36807336]
Saifi MA, Godugu C Copper chelation therapy inhibits renal fibrosis by modulating copper transport proteins BioFactors (Oxford, England) 2022-03-24 [PMID: 35322483]
Aloysius Dhivya M, Sulochana K, Devi S High glucose induced inflammation is inhibited by copper chelation via rescuing mitochondrial fusion protein 2 in retinal pigment epithelial cells Cellular Signalling 2022-01-01 [PMID: 34999205] (WB, Human) WB Human
Liu LL, Du D, Zheng W, Zhang Y Age-dependent Decline of Copper Clearance at the Blood-Cerebrospinal Fluid Barrier Neurotoxicology 2021-10-27 [PMID: 34718061] (IF/IHC, WB, Rat) IF/IHC, WB Rat
Guo J, Cheng J, Zheng N Et Al. Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021-07-18 [PMID: 34278744]
Schoonover KE, Kennedy WM, Roberts RC Cortical copper transporter expression in schizophrenia: interactions of risk gene dysbindin-1 Journal of neural transmission (Vienna, Austria : 1996) 2021-04-22 [PMID: 33890175] (WB, Human) WB Human
Tsai TL, Lai YH, Hw Chen H, Su WC Overcoming Radiation Resistance by Iron-Platinum Metal Alloy Nanoparticles in Human Copper Transport 1-Overexpressing Cancer Cells via Mitochondrial Disturbance International journal of nanomedicine 2021-03-09 [PMID: 33727814] (WB, Human) WB Human
Schoonover KE, Farmer CB, Morgan CJ, et al. Abnormalities in the copper transporter CTR1 in postmortem hippocampus in schizophrenia: A subregion and laminar analysis Schizophrenia research 2021-01-09 [PMID: 33434736] (IF/IHC) IF/IHC
Schoonover KE, Roberts RC Markers of copper transport in the cingulum bundle in schizophrenia Schizophrenia research 2021-01-09 [PMID: 33434726] (WB, Human) WB Human
Yu Z, Mersaoui S, Guitton-Sert L et al. DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions NAR Cancer 2020-10-05 [PMID: 33015627] (WB) WB
Show All 30 Publications.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for SLC31A1/CTR1 Antibody (NB100-402). (Showing 1 - 4 of 4 FAQs).

  1. Could you provide the immunogen sequence of this antibody?
    • The immunogen sequence for this product is considered proprietary, but I can tell you it falls within amino acids 160-190 of CTR1.
  2. We have bought and used the SLC31A1/CTR1 antibody (Novus Biologicals; catnr. NB100-402) successfully for our Western blot and IHC analysis. We want to publish this, but the reviewers urged us to do a control experiment using a corresponding blocking peptide. Do you have the peptide available by which we can block the specific binding of this anti-SLC31A1 antibody?
    • Thank you for contacting us regarding your successful use of our product. In regards to your inquiry, I have done a search of our products, and unfortunately, we do not have the blocking peptide for that particular antibody (NB100-402). I apologize for any inconvenience this may cause you.
  3. Could you please tell me the targeted amino acids of the CTR1 antibody NB100-402?
    • Unfortunately, we cannot disclose that information. However, since human SLC31A1 is a small protein (, I anticipate that so called ".. A synthetic peptide derived from a C-terminal sequence .. " should be located within a.a. 140 - 190.
  4. What is the molecular weight of CTR1?  
    • The theoretical molecular weight of CTR1 is 21kDa. The protein can run slightly higher in western blot due to PTMs.

Secondary Antibodies


Isotype Controls

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Blogs on SLC31A1/CTR1.

SLC31A1/CTR1 - a copper transporter with important implications for platinum-based chemotherapy
Copper is an essential micronutrient that serves as a cofactor in numerous biological processes, but can be toxic when present in excess. Because of this, cells must tightly maintain copper levels. This includes balance between import and export of...  Read full blog post.

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Gene Symbol SLC31A1