Calcitonin R Antibody (462802) [Unconjugated]

Images

 
Genetic Strategies: Calcitonin R knockout MCF-7 human breast cancer cell line was stained with Mouse Anti-Human Calcitonin R Monoclonal Antibody (Catalog # MAB4614, filled histogram) or isotype control antibody ...read more
MCF‑7 human breast cancer cell line was stained with Mouse Anti-Human Calcitonin R Monoclonal Antibody (Catalog # MAB4614, filled histogram) or isotype control antibody (Catalog # MAB003, open histogram), followed by ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready, KO
Clone
462802
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH
Validated by:
     

Genetic Strategies

   

Order Details

Calcitonin R Antibody (462802) [Unconjugated] Summary

Immunogen
HEK293 human embryonic kidney cell line transfected with human Calcitonin R
Ala25-Ala474
Accession # NP_001733
Specificity
Detects human Calcitonin R. Stains human Calcitonin R transfectants but not irrelevant transfectants.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
CALCR
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
  • Knockout Validated 0.25 ug/10^6 cells
Publications
Read Publications using
MAB4614 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Calcitonin R Antibody (462802) [Unconjugated]

  • Calcitonin R
  • calcitonin receptor
  • CalcitoninR
  • CALCR
  • CRT
  • CTR
  • CT-R
  • CTR1

Background

Calcitonin receptor (CALCR) is a glycosylated 70 kDa seven-transmembrane G protein-coupled receptor that mediates the hypocalcemic effects of the peptide hormone, calcitonin. CALCR activation inhibits osteoclast-mediated bone resorption and enhances renal calcium excretion. CALCR polymorphisms and mutations have been associated with several bone disorders. Alternative splicing results in the deletion of 16 aa in the first cytoplasmic loop or 23 aa in the first extracellular region. Human CALCR shares 70%‑72% aa sequence identity with mouse and rat CACLR.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Calcitonin R Antibody (MAB4614)(6)

We have publications tested in 2 confirmed species: Human, Primate - Chlorocebus aethiops (African Green Monkey).

We have publications tested in 3 applications: Flow Cytometry, ICC, IHC.


Filter By Application
Flow Cytometry
(2)
ICC
(3)
IHC
(1)
All Applications
Filter By Species
Human
(5)
Primate - Chlorocebus aethiops (African Green Monkey)
(1)
All Species
Showing Publications 1 - 6 of 6.
Publications using MAB4614 Applications Species
D Steller, A Scheibert, T Sturmheit, SG Hakim Establishment and validation of an in vitro co-culture model for oral cell lines using human PBMC-derived osteoclasts, osteoblasts, fibroblasts and keratinocytes Sci Rep, 2020;10(1):16861. 2020 [PMID: 33033302] (Flow Cytometry, Human) Flow Cytometry Human
J Costa-Rodr, MH Fernandes, O Pinho, PRR Monteiro Modulation of human osteoclastogenesis and osteoblastogenesis by lycopene J. Nutr. Biochem., 2018;57(0):26-34. 2018 [PMID: 29655028] (ICC, Human) ICC Human
Dal Maso E, Zhu Y, Pham V, Reynolds C, Deganutti G, Hick C, Yang D, Christopoulos A, Hay D, Wang M, Sexton P, Furness S, Wootten D Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy. Biochem Pharmacol, 0;150(0):214-244. 0 [PMID: 29454620] (Flow Cytometry, Primate - Chlorocebus aethiops (African Green Monkey)) Flow Cytometry Primate - Chlorocebus aethiops (African Green Monkey)
Kasonga A, Deepak V, Kruger M, Coetzee M Arachidonic acid and docosahexaenoic acid suppress osteoclast formation and activity in human CD14+ monocytes, in vitro. PLoS ONE, 2015;10(4):e0125145. 2015 [PMID: 25867515] (IHC, Human) IHC Human
Costa-Rodrigues J, Martins EG, Fernandes MH Induced osteoclastogenesis by fluoroquinolones in unstimulated and stimulated human osteoclast precursor cells. Bone, 2012;51(1):17-27. 2012 [PMID: 22481084] (ICC, Human) ICC Human
Costa-Rodrigues J, Teixeira CA, Sampaio P, Fernandes MH Characterisation of the osteoclastogenic potential of human osteoblastic and fibroblastic conditioned media. J. Cell. Biochem., 2010;109(1):205-16. 2010 [PMID: 19911374] (ICC, Human) ICC Human

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Bioinformatics

Gene Symbol CALCR
Uniprot