SIRT6 Antibody


Western Blot: SIRT6 Antibody [NB100-2523] - Detection of SIRT6 in HeLa whole cell lysate.
Simple Western: SIRT6 Antibody [NB100-2523] - Simple Western lane view shows a specific band for SIRT6 in 0.5 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa more

Product Details

Reactivity HuSpecies Glossary
Applications WB, Simple Western
1 mg/ml

SIRT6 Antibody Summary

A synthetic peptide made to an internal region of the human SIRT6 protein (within residues 250-350). [Swiss-Prot Q8N6T7]
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
Tris-citrate/phosphate, pH 7-8
0.1% Sodium Azide
1 mg/ml
Immunogen affinity purified


Application Notes
This SIRT6 antibody is useful for Western blot analysis, where a band is seen at ~39 kDa. A higher MW band ~59 kDa may be seen with lower dilutions (ie: 2 ug/ml). This antibody is not applicable for Immunocytochemistry / Immunofluorescence.In Simple Western only 10-15 uL of the recommended dilution is used per data point.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
39 kDa
Control Peptide
SIRT6 Peptide (NB100-2523PEP)

Reactivity Notes

Human. Immunogen sequence has 78% homology to mouse protein and 71% homology to rat.

Alternate Names for SIRT6 Antibody

  • EC 3.5.1.-
  • NAD-dependent deacetylase sirtuin-6
  • SIR2L6sir2-related protein type 6
  • SIR2-like protein 6
  • sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
  • sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6
  • sirtuin 6
  • sirtuin type 6


SIRT6 (SIR2-like protein 6) is a member of the yeast silent information regulator 2 (SIR2) family and possesses both strong ADP-ribosyltransferase activity as well as protein deacetylase activity which is dependent on NAD(+). SIRT6 exerts deacetylase activity towards histone H3K9Ac and H3K56Ac, and alters histone H3 acetylation in telomeric chromatin during cell cycle's S-phase. It deacetylates histone H3K9Ac at NFkB target promoters and downregulates a subset of NFkB target genes. Upon DNA damage, SIRT6 promotes DNA end resection via deacetylation of RBBP8. SIRT6 also serves as a corepressor of the transcription factor HIF1 alpha for regulating the expression of multiple glycolytic genes to control glucose homeostasis, and is required for normal IGF1 serum levels. SIRT6 play critical roles in maintaining telomere integrity, fine-tuning aging-associated gene expression programs, preventing genomic instability, and maintaining metabolic homeostasis, thus impacting on several pathways relevant for cancer, metabolism, aging, cellular senescence and apoptosis.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

View specific protocols for SIRT6 Antibody (NB100-2523): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB100-2523AF405
Alexa Fluor (R) 488 Labeled NB100-2523AF488
Alexa Fluor (R) 647 Labeled NB100-2523AF647
Alexa Fluor (R) 700 Labeled NB100-2523AF700
Biotin Labeled NB100-2523B
DyLight 405 Labeled NB100-2523V
DyLight 488 Labeled NB100-2523G
DyLight 550 Labeled NB100-2523R
DyLight 650 Labeled NB100-2523C
FITC Labeled NB100-2523F
HRP Labeled NB100-2523H

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Contact Information

Product PDFs


Gene Symbol SIRT6

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