Serpin B5/Maspin Antibody


Western Blot: MASPIN Antibody [NB110-97377] - Detection of Maspin in HeLa whole cell extracts using NB110-97377.

Product Details

Reactivity HuSpecies Glossary
Applications WB, ICC/IF (-)
1 mg/ml

Serpin B5/Maspin Antibody Summary

Synthetic peptide made to an internal portion of human MASPIN (within residues 100-200). [Swiss-Prot# P36952]
Secreted, extracellular space.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS, 30% glycerol
0.1% Sodium Azide
1 mg/ml
Immunogen affinity purified


Application Notes
This MASPIN antibody is useful for Western blot, where a doublet is seen at ~40 kDa. Does not work in Immunocytochemistry/Immunofluorescence.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
40 kDa
Control Peptide
Serpin B5/Maspin Peptide (NB110-97377PEP)

Reactivity Notes


Alternate Names for Serpin B5/Maspin Antibody

  • Maspin
  • Peptidase inhibitor 5
  • PI5
  • PI-5
  • PI5protease inhibitor 5 (maspin)
  • serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
  • serpin B5
  • serpin peptidase inhibitor, clade B (ovalbumin), member 5


MASPIN (mammary serine protease inhibitor; SERPINB5 or PI5), is a member of SERPIN superfamily (serine protease inhibitor/non-inhibitor) which also includes certain other proteins such as plasminogen activator inhibitors 1/2 and alpha1-antitrypsin. MASPIN is an extracellular matrix tumor supressor which blocks the proliferative, invasive, and metastatic properties of breast as well as prostate cancers. Because it does not undergo S (stressed) to R (relaxed) conformational transition characteristic of active SERPINS, MASPIN does not exhibit serine protease inhibitory activity. MASPIN expression is down-regulated in breast, prostate, gastric and melanoma cancers, however, this protein is overexpressed in certain other malignancies such as pancreatic, gallbladder, colorectal, and thyroid cancers which reflects that MASPIN may play different activities in different cell types. These observations may be explained by MASPIN's distinct subcellular localization - cytoplasmic, nuclear or both cytoplasmic-nuclear expression; by interactions with extracellular matrix; its structure and epigenetic modifications. MASPIN is also expressed in corneal epithelial tissue, wherein it controls the migration/adhesion of corneal stromal fibroblasts and myofibroblasts during corneal wound healing.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB110-97377AF405
Alexa Fluor (R) 488 Labeled NB110-97377AF488
Alexa Fluor (R) 647 Labeled NB110-97377AF647
Alexa Fluor (R) 700 Labeled NB110-97377AF700
Biotin Labeled NB110-97377B
DyLight 405 Labeled NB110-97377V
DyLight 488 Labeled NB110-97377G
DyLight 550 Labeled NB110-97377R
DyLight 650 Labeled NB110-97377C
FITC Labeled NB110-97377F
HRP Labeled NB110-97377H

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Contact Information

Product PDFs


Gene Symbol SERPINB5

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