Serpin A8/Angiotensinogen Antibody (369439)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
369439
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

Serpin A8/Angiotensinogen Antibody (369439) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Serpin A8/Angiotensinogen
Asp34-Ala485
Accession # P01019
Specificity
Detects human Serpin A8/Angiotensinogen in direct ELISAs and Western blots. Shows no cross-reactivity with recombinant human Serpin A1, -A3, -A4, -A5, -A6, -C1, -D1, -E2, -F1, -F2, -G1, -I1, -I2, -B6, -B8, -B9, or recombinant mouse Serpin A6.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
AGT
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB3156 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin A8/Angiotensinogen Antibody (369439)

  • AGT
  • alpha-1 antiproteinase, antitrypsin
  • Angiotensin II
  • angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
  • Angiotensinogen
  • ANHU
  • Aogen
  • FLJ92595
  • FLJ97926
  • PAT
  • pre-angiotensinogen
  • serine (or cysteine) proteinase inhibitor
  • Serpin A8
  • SERPINA8angiotensin I

Background

Angiotensinogen, a member of the serpin family (Serpin A8), is synthesized in liver and cleaved by renin to produce angiotensin I. This is further processed by angiotensin converting enzyme (ACE) to yield angiotensin II, a key blood pressure regulator. The amino acid sequence of human AGT is 99%, 68%, 64%, and 61% identical to that of chimpanzee, canine, rat, and mouse.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Serpin A8/Angiotensinogen Antibody (MAB3156)(5)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ELISA Development (Capture), IHC.


Filter By Application
ELISA Development (Capture)
(1)
IHC
(1)
All Applications
Filter By Species
Human
(2)
All Species
Showing Publications 1 - 5 of 5.
Publications using MAB3156 Applications Species
Jennifer M. Crowther, Letitia H. Gilmour, Benjamin T. Porebski, Sarah G. Heath, Neil R. Pattinson, Maurice C. Owen et al. Molecular basis of a redox switch: molecular dynamics simulations and surface plasmon resonance provide insight into reduced and oxidised angiotensinogen Biochemical Journal 2021-09-17 [PMID: 34424335]
Lina A. Dahabiyeh, David Tooth, Robin W. Carrell, Randy J. Read, Yahui Yan, Fiona Broughton Pipkin et al. Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS Analytical and Bioanalytical Chemistry 2019-01-01 [PMID: 30465161]
Bryan Q. Spring, R. Bryan Bryan Sears, Lei Zak Zheng, Zhiming Mai, Reika Watanabe, Margaret E. Sherwood et al. A photoactivable multi-inhibitor nanoliposome for tumour control and simultaneous inhibition of treatment escape pathways Nature Nanotechnology 2016-04-01 [PMID: 26780659]
Rahgozar S, Amirian T, Qi M, Shahshahan Z, Entezar-E-Ghaem M, Ghasemi Tehrani H, Miroliaei M, Krilis S, Giannakopoulos B Improved Assay for Quantifying a Redox Form of Angiotensinogen as a Biomarker for Pre-Eclampsia: A Case-Control Study. PLoS ONE, 2015-08-27;10(8):e0135905. 2015-08-27 [PMID: 26312482] (ELISA Development (Capture), Human) ELISA Development (Capture) Human
Park H, Kang A, Jang J, Kim H, Han M, Oh K, Kim S, Noh J, Cheong H, Hwang Y, Ahn C Increased urinary Angiotensinogen/Creatinine (AGT/Cr) ratio may be associated with reduced renal function in autosomal dominant polycystic kidney disease patients. BMC Nephrol, 2015-06-20;16(0):86. 2015-06-20 [PMID: 26092580] (IHC, Human) IHC Human

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Bioinformatics

Gene Symbol AGT
Uniprot