Semaphorin 6D Antibody (257510) [DyLight 594]

• Reactivity: Hu
• Applications: WB
• Clone: 257510
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 594

Semaphorin 6D Antibody (257510) [DyLight 594] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Semaphorin 6D
  Ser22-His660
  Accession # Q8NFY4
• Specificity: Detects human Semaphorin 6D in direct ELISAs and Western blots. In Western blots, approximately 10% cross‑reactivity with recombinant human (rh) Semaphorin 3A and recombinant mouse (rm) Semaphorin 3C is observed and no cross‑reactivity with rhSemaphorin 3B, 6A, 6B, 6C, 7A, rmSemaphorin 3E, 3F, or 6D is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: SEMA6D
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Semaphorin 6D Antibody (257510) [DyLight 594]

• KIAA1479FLJ11598
• sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
• Sema6D
• Semaphorin 6D
• semaphorin-6D

Background

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Six transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SEMA6D