Semaphorin 6D Products

Description

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Six transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq]

Bioinformatics

Entrez	80031 Human
Uniprot	A6NM95 Human NM_020858 Human NM_024966 Human NM_153616 Human NM_153617 Human NM_153618 Human NM_153619 Human NP_079242 Human NP_079242.2 Human NP_705870 Human NP_705871 Human NP_705871.1 Human Q8NFY4 Human
Product By Gene ID	80031
Alternate Names	KIAA1479FLJ11598 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D semaphorin-6D