Recombinant Mouse Noggin Protein, CF

Recombinant mouse Noggin (1967-NG/CF) inhibits recombinant human BMP-4-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED50 for this effect is 0.06-0.3 µg/mL in the presence of 50 ng/mL of recombinant human BMP-4 (314-BP).

• Reactivity: Mu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Mouse Noggin Protein, CF Summary

• Additional Information: A New rm Noggin is Now Available! ~2 fold better activity; Lower endotoxin specification; Enhanced purity; No tag!
• Details of Functionality: Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED 50 for this effect is 0.06-0.3 µg/mL in the presence of 50 ng/mL of Recombinant Human BMP-4 (Catalog # 314-BP).
• Source: Mouse myeloma cell line, NS0-derived mouse Noggin protein

  Mouse Noggin (Leu20-Cys232) Accession # P97466

  IEGRGGGSGGGSGGGS

  10-His tag

  N-terminus

  C-terminus

• Accession #: P97466
• N-terminal Sequence: Leu20
• Structure / Form: Disulfide-linked homodimer
• Protein/Peptide Type: Recombinant Proteins
• Gene: Nog
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 26 kDa (monomer).
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 30-35 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 3 months, -20 to -70 degreesC under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse Noggin Protein, CF

• NOG
• Noggin
• SYM1
• symphalangism 1 (proximal)
• synostoses (multiple) syndrome 1
• SYNS1
• SYNS1A

Background

Noggin was originally cloned based on its dorsalizing activity in Xenopus embryos. Mammalian Noggins were subsequently identified and cloned from human, mouse and rat cDNA libraries. Mouse Noggin cDNA encodes a 232 amino acid (aa) residue precursor protein with 19 aa residue putative signal peptide that is cleaved to generate the 213 aa residue mature protein which is secreted as a homodimeric glycoprotein. Noggin is a highly conserved molecule. Mature mouse Noggin shares 99% and 83% aa sequence identity with human and Xenopus Noggin, respectively. Noggin has a complex pattern of expression during embryogenesis. In the adult, Noggin is expressed in the central nervous system and in several adult peripheral tissues such as lung, skeletal muscle and skin. Noggin has been shown to be a high-affinity BMP (bone morphogenetic protein) binding protein that antagonizes BMP bioactivities.

1. Smith, W.C. and R.M. Harland (1992) Cell 70:829.
2. Valenzuela, D.M. et al. (1995) J. Neurosci. 15:6077.
3. Brunet, L.J. et al. (1998) Science 280:1455.

Publications for Noggin (1967-NG/CF)(84)

Publications using 1967-NG/CF

• A Yamada, K Yoshizaki, K Saito, M Ishikawa, Y Chiba, S Hoshikawa, M Chiba, R Hino, Y Maruya, H Sato, K Masuda, H Yamaza, T Nakamura, T Iwamoto, S Fukumoto GSK3beta inhibitor-induced dental mesenchymal stem cells regulate ameloblast differentiation Journal of oral biosciences, 2022-10-18;0(0):. 2022-10-18 [PMID: 36270608] (Bioassay, Rat)
• ALM Caldwell, L Sancho, J Deng, A Bosworth, A Miglietta, JK Diedrich, MN Shokhirev, NJ Allen Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders Nature Neuroscience, 2022-08-30;25(9):1163-1178. 2022-08-30 [PMID: 36042312] (Bioassay, Mouse)
• S Watanabe, S Kobayashi, N Ogasawara, R Okamoto, T Nakamura, M Watanabe, KB Jensen, S Yui Transplantation of intestinal organoids into a mouse model of colitis Nature Protocols, 2022-02-02;0(0):. 2022-02-02 [PMID: 35110738] (Bioassay, Mouse)
• TY Kim, S Kim, Y Kim, YS Lee, S Lee, SH Lee, MN Kweon A High-Fat Diet Activates the BAs-FXR Axis and Triggers Cancer-Associated Fibroblast Properties in the Colon Cellular and Molecular Gastroenterology and Hepatology, 2021-12-29;0(0):. 2021-12-29 [PMID: 34971821] (Bioassay, Mouse)
• KM Mackinlay, BA Weatherbee, V Souza Rosa, CE Handford, G Hudson, T Coorens, LV Pereira, S Behjati, L Vallier, MN Shahbazi, M Zernicka-G An in vitro stem cell model of human epiblast and yolk sac interaction Elife, 2021-08-17;10(0):. 2021-08-17 [PMID: 34403333] (Bioassay, Human)
• ACP Correia, D Straub, S Calpe, KK Krishnadat Novel In Vivo Mouse Cryoablation Model to Explore Unique Therapeutic Approaches for Premalignant Columnar Lesions Methods and protocols, 2021-01-05;4(1):. 2021-01-05 [PMID: 33526760] (Bioassay, Mouse)
• R Morikawa, Y Nemoto, Y Yonemoto, S Tanaka, Y Takei, S Oshima, T Nagaishi, K Tsuchiya, K Nozaki, T Mizutani, T Nakamura, M Watanabe, R Okamoto Intraepithelial lymphocytes suppress the intestinal tumor growth by cell-to-cell contact via CD103/E-cadherin signal Cellular and Molecular Gastroenterology and Hepatology, 2021-01-28;0(0):. 2021-01-28 [PMID: 33515805] (Bioassay, Mouse)
• AJ Bilotta, C Ma, W Yang, Y Yu, Y Yu, X Zhao, Z Zhou, S Yao, SM Dann, Y Cong Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and Repair Cell Mol Gastroenterol Hepatol, 2020-11-22;0(0):. 2020-11-22 [PMID: 33238220] (Cell Culture, Mouse)
• SY Chien, CH Tsai, SC Liu, CC Huang, TH Lin, YZ Yang, CH Tang Noggin Inhibits IL-1&amp;beta and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis Cells, 2020-04-10;9(4):. 2020-04-10 [PMID: 32290085] (In Vivo, Mouse)
• M Binder, LC Biggs, MS Kronenberg, P Schneider, I Thesleff, A Balic Novel strategies for expansion of tooth epithelial stem cells and ameloblast generation Sci Rep, 2020-03-18;10(1):4963. 2020-03-18 [PMID: 32188889] (Cell Culture, Mouse)
• S Kang, K Long, S Wang, A Sada, T Tumbar Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin Stem Cell Reports, 2019-12-19;0(0):. 2019-12-19 [PMID: 31866458] (In Vivo, Mouse)
• M Ali, F Kabir, JJ Thomson, Y Ma, C Qiu, M Delannoy, SY Khan, SA Riazuddin Comparative transcriptome analysis of hESC- and iPSC-derived lentoid bodies Sci Rep, 2019-12-06;9(1):18552. 2019-12-06 [PMID: 31811247] (Bioassay, Human)
• PG Boone, LK Rochelle, JD Ginzel, V Lubkov, WL Roberts, PJ Nicholls, C Bock, ML Flowers, RJ von Furste, BR Stripp, P Agarwal, AD Borowsky, RD Cardiff, LS Barak, MG Caron, HK Lyerly, JC Snyder A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion Nat Commun, 2019-12-02;10(1):5490. 2019-12-02 [PMID: 31792216] (Cell Culture, Mouse)
• LG Jones, A Vaida, LM Thompson, FI Ikuomola, JH Caamaño, MD Burkitt, F Miyajima, JM Williams, BJ Campbell, DM Pritchard, CA Duckworth NF-kappaB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells Cell Death Dis, 2019-11-26;10(12):896. 2019-11-26 [PMID: 31772152] (Tissue Culture, Mouse)
• M Bakhti, K Scheibner, S Tritschler, A Bastidas-P, M Tarquis-Me, FJ Theis, H Lickert Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in�vitro Mol Metab, 2019-09-24;30(0):16-29. 2019-09-24 [PMID: 31767167] (Bioassay, Mouse)
• C Chen, Y Yang, Y Yao HBO Promotes the Differentiation of Neural Stem Cells via Interactions Between the Wnt3/beta-Catenin and BMP2 Signaling Pathways Cell Transplant, 2019-11-06;0(0):9636897198835. 2019-11-06 [PMID: 31694396] (Cell Culture, Rat)
• F Inoue, A Kreimer, T Ashuach, N Ahituv, N Yosef Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction Cell Stem Cell, 2019-10-17;0(0):. 2019-10-17 [PMID: 31631012] (Bioassay, Human)
• Y Kim, YS Lee, SW Kang, S Kim, TY Kim, SH Lee, SW Hwang, J Kim, EN Kim, JS Ju, YY Park, MN Kweon Loss of PKM2 in Lgr5+ intestinal stem cells promotes colitis-associated colorectal cancer Sci Rep, 2019-04-17;9(1):6212. 2019-04-17 [PMID: 30996297] (Bioassay, Mouse)
• Z Meng, T Gwag, Y Sui, SH Park, X Zhou, C Zhou The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling JCI Insight, 2019-02-07;4(3):. 2019-02-07 [PMID: 30728326] (Bioassay, Mouse)
• L Yu, LA Dawson, M Yan, K Zimmel, YL Lin, CP Dolan, M Han, K Muneoka BMP9 stimulates joint regeneration at digit amputation wounds in mice Nat Commun, 2019-02-05;10(1):424. 2019-02-05 [PMID: 30723209] (Bioassay, Mouse)
• AM Lager, OG Corradin, JM Cregg, MS Elitt, HE Shick, BLL Clayton, KC Allan, HE Olsen, M Madhavan, PJ Tesar Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells Nat Commun, 2018-09-13;9(1):3708. 2018-09-13 [PMID: 30213958] (Cell Culture, Mouse)
• F Chen, W Yang, X Huang, AT Cao, AJ Bilotta, Y Xiao, M Sun, L Chen, C Ma, X Liu, CG Liu, S Yao, SM Dann, Z Liu, Y Cong Neutrophils Promote Amphiregulin Production in Intestinal Epithelial Cells through TGF-? and Contribute to Intestinal Homeostasis J. Immunol., 2018-08-31;0(0):. 2018-08-31 [PMID: 30171165] (Bioassay, Mouse)
• A Spangler, EY Su, AM Craft, P Cahan A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo Stem Cell Res, 2018-07-29;31(0):201-215. 2018-07-29 [PMID: 30118958] (Bioassay, Mouse)
• YA Choksi, VK Reddy, K Singh, CW Barrett, SP Short, B Parang, CE Keating, JJ Thompson, TG Verriere, RE Brown, MB Piazuelo, DM Bader, MK Washington, MK Mittal, T Brand, AP Gobert, LA Coburn, KT Wilson, CS Williams BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability Mucosal Immunol, 2018-06-15;0(0):. 2018-06-15 [PMID: 29907869] (Bioassay, Mouse)
• M Boyd, M Thodberg, M Vitezic, J Bornholdt, K Vitting-Se, Y Chen, M Coskun, Y Li, BZS Lo, P Klausen, P Jan Schwei, AG Pedersen, N Rapin, K Skovgaard, K Dahlgaard, R Andersson, TB Terkelsen, B Lilje, JT Troelsen, AM Petersen, KB Jensen, I Gögenur, P Thielsen, JB Seidelin, OH Nielsen, JT Bjerrum, A Sandelin Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies Nat Commun, 2018-04-25;9(1):1661. 2018-04-25 [PMID: 29695774] (Bioassay, Human)
• BA Willems, M Furmanik, MMJ Caron, MLL Chatrou, DHM Kusters, TJM Welting, M Stock, MS Rafael, CSB Viegas, DC Simes, C Vermeer, CPM Reutelings, LJ Schurgers Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling Sci Rep, 2018-03-21;8(1):4961. 2018-03-21 [PMID: 29563538] (Bioassay, Mouse)
• JJ Brown, SP Short, J Stencel-Ba, K Urbanek, AJ Pruijssers, N McAllister, M Ikizler, G Taylor, P Aravamudha, S Khomandiak, B Jabri, CS Williams, TS Dermody Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection J. Virol., 2018-04-27;0(0):. 2018-04-27 [PMID: 29514905] (Bioassay, Mouse)
• T Takahashi, A Shiraishi, J Murata The Coordinated Activities of nAChR and Wnt Signaling Regulate Intestinal Stem Cell Function in Mice Int J Mol Sci, 2018-03-05;19(3):. 2018-03-05 [PMID: 29510587] (Bioassay, Mouse)
• E Järvinen, J Shimomura-, A Balic, M Jussila, I Thesleff Mesenchymal Wnt/?-catenin signaling limits tooth number Development, 2018;0(0):. 2018 [PMID: 29437780] (Tissue Culture, Mouse)
• B Li, C Dorrell, PS Canaday, C Pelz, A Haft, M Finegold, M Grompe Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes Stem Cell Reports, 2017-07-06;0(0):. 2017-07-06 [PMID: 28689996] (Bioassay, Mouse)
• O Bernatik, T Radaszkiew, M Behal, Z Dave, F Witte, A Mahl, NH Cernohorsk, P Krejci, S Stricker, V Bryja A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation Front Cell Dev Biol, 2017-05-04;5(0):47. 2017-05-04 [PMID: 28523267] (Bioassay, Mouse, Rat)
• JR Chao, DA Lamba, TR Klesert, A Torre, A Hoshino, RJ Taylor, A Jayabalu, AL Engel, TH Khuu, RK Wang, M Neitz, J Neitz, TA Reh Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate Transl Vis Sci Technol, 2017-05-16;6(3):4. 2017-05-16 [PMID: 28516002] (Bioassay, Human)
• KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling Cell Stem Cell, 2017-03-30;0(0):. 2017-03-30 [PMID: 28366587] (Bioassay, Mouse)
• J Lee, ER Snyder, Y Liu, X Gu, J Wang, BM Flowers, YJ Kim, S Park, GL Szot, RH Hruban, TA Longacre, SK Kim Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells Nat Commun, 2017-03-08;8(0):14686. 2017-03-08 [PMID: 28272465] (Bioassay, Human)
• I Espuny-Cam, AM Arranz, M Fiers, A Snellinx, K Ando, S Munck, J Bonnefont, L Lambot, N Corthout, L Omodho, E Vanden Eyn, E Radaelli, I Tesseur, S Wray, A Ebneth, J Hardy, K Leroy, JP Brion, P Vanderhaeg, B De Stroope Hallmarks of Alzheimer&#039;s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain Neuron, 2017-02-23;0(0):. 2017-02-23 [PMID: 28238547] (Bioassay, Human, Mouse)
• C Barry, MT Schmitz, P Jiang, MP Schwartz, BM Duffin, S Swanson, R Bacher, JM Bolin, AL Elwell, BE McIntosh, R Stewart, JA Thomson Species-specific developmental timing is maintained by pluripotent stem cells ex utero Dev. Biol., 2017-02-06;423(2):101-110. 2017-02-06 [PMID: 28179190] (Differentiation, Differentiation, Mouse)
• L Nigmatulli, M Norkin, MM Dzama, B Messner, S Sayols, N Soshnikova Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development EMBO J., 2017-01-11;36(7):869-885. 2017-01-11 [PMID: 28077488] (Bioassay, Mouse)
• Electrical stimulation drives chondrogenesis of mesenchymal stem cells in the absence of exogenous growth factors Sci Rep, 2016-12-22;6(0):39302. 2016-12-22 [PMID: 28004813] (Bioassay, Mouse)
• Divya Varun A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs) Acta Biomater, 2016-10-27;0(0):. 2016-10-27 [PMID: 27989923] (Bioassay, Human)
• Toru Nakata Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors Biochem. Biophys. Res. Commun, 2016-12-08;0(0):. 2016-12-08 [PMID: 27939883] (Bioassay)
• J Lee, S Kang, KC Lilja, KJ Colletier, CJ Scheitz, YV Zhang, T Tumbar Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis Nat Commun, 2016-04-15;7(0):11278. 2016-04-15 [PMID: 27080563] (In Vivo, Mouse)
• Carthy J, Engstrom U, Heldin C, Moustakas A Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-beta Signaling. J Cell Biochem, 2015-09-22;117(4):938-45. 2015-09-22 [PMID: 26369756] (Bioassay, Mouse)
• Barrett C, Reddy V, Short S, Motley A, Lintel M, Bradley A, Freeman T, Vallance J, Ning W, Parang B, Poindexter S, Fingleton B, Chen X, Washington M, Wilson K, Shroyer N, Hill K, Burk R, Williams C Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. J Clin Invest, 2015-06-08;125(7):2646-60. 2015-06-08 [PMID: 26053663] (Bioassay, Mouse)
• Shojaie S, Ermini L, Ackerley C, Wang J, Chin S, Yeganeh B, Bilodeau M, Sambi M, Rogers I, Rossant J, Bear C, Post M Acellular lung scaffolds direct differentiation of endoderm to functional airway epithelial cells: requirement of matrix-bound HS proteoglycans. Stem Cell Reports, 2015-02-05;4(3):419-30. 2015-02-05 [PMID: 25660407] (Bioassay, Mouse)
• Gottle P, Sabo J, Heinen A, Venables G, Torres K, Tzekova N, Parras C, Kremer D, Hartung H, Cate H, Kury P Oligodendroglial maturation is dependent on intracellular protein shuttling. J Neurosci, 2015-01-21;35(3):906-19. 2015-01-21 [PMID: 25609610] (In Vivo, Mouse)
• McElroy S, Castle S, Bernard J, Almohazey D, Hunter C, Bell B, Al Alam D, Wang L, Ford H, Frey M The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis. Am J Pathol, 2014-09-09;184(10):2768-78. 2014-09-09 [PMID: 25216938] (Bioassay, Mouse)
• Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, Ichinose S, Okada Y, Tanaka T, Watanabe M, Nakamura T Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon. Genes Dev, 2014-08-15;28(16):1752-7. 2014-08-15 [PMID: 25128495] (Bioassay, Mouse)
• Capaldo C, Farkas A, Hilgarth R, Krug S, Wolf M, Benedik J, Fromm M, Koval M, Parkos C, Nusrat A Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins. Mol Biol Cell, 2014-07-16;25(18):2710-9. 2014-07-16 [PMID: 25031428] (Bioassay, Mouse)
• Poh Y, Chen J, Hong Y, Yi H, Zhang S, Chen J, Wu D, Wang L, Jia Q, Singh R, Yao W, Tan Y, Tajik A, Tanaka T, Wang N Generation of organized germ layers from a single mouse embryonic stem cell. Nat Commun, 2014-05-30;5(0):4000. 2014-05-30 [PMID: 24873804] (Bioassay, Mouse)
• Park J, Jang S, Park D, Lim N, Deng C, Kim D, Green J, Kim H Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis. Mol Cancer Res, 2014-04-30;12(8):1088-99. 2014-04-30 [PMID: 24784840] (Bioassay, Mouse)
• Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley D, Ishii K, Kiyono H, Akira S, Uematsu S Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun, 2014-03-18;5(0):3492. 2014-03-18 [PMID: 24637670] (Bioassay, Mouse)
• Yap C, Goh H, Familari M, Rathjen P, Rathjen J The formation of proximal and distal definitive endoderm populations in culture requires p38 MAPK activity. J Cell Sci, 2014-01-30;127(0):2204-16. 2014-01-30 [PMID: 24481813] (Bioassay, Mouse)
• Singh A, Chappell J, Trost R, Lin L, Wang T, Tang J, Matlock B, Weller K, Wu H, Zhao S, Jin P, Dalton S Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells. Stem Cell Reports, 2013-12-05;1(6):532-44. 2013-12-05 [PMID: 24371808] (Bioassay, Human)
• Brafman D, Moya N, Allen-Soltero S, Fellner T, Robinson M, McMillen Z, Gaasterland T, Willert K Analysis of SOX2-expressing cell populations derived from human pluripotent stem cells. Stem Cell Reports, 2013-10-31;1(5):464-78. 2013-10-31 [PMID: 24286033] (Bioassay, Mouse)
• Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann J, Miyazaki S, Miyazaki J, Szot G, Bottino R, Kim S Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife, 2013-11-19;2(0):e00940. 2013-11-19 [PMID: 24252877]
• Guan J, Li H, Lv T, Chen D, Yuan Y, Qu S Bone morphogenetic protein-7 (BMP-7) mediates ischemic preconditioning-induced ischemic tolerance via attenuating apoptosis in rat brain. Biochem Biophys Res Commun, 2013-10-30;441(3):560-6. 2013-10-30 [PMID: 24184479] (Rat)
• Lewis , Christop, Mardaryev , Andrei N, Poterlowicz , Krzyszto, Sharova , Tatyana, Aziz , Ahmar, Sharpe , David T, Botchkareva , Natalia, Sharov , Andrey A Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration. J Invest Dermatol, 2013-10-14;134(3):827-37. 2013-10-14 [PMID: 24126843] (Bioassay, Mouse)
• Wang , Yidong, Wu , Bingruo, Chamberlain , Alyssa A, Lui , Wendy, Koirala , Pratisth, Susztak , Katalin, Klein , Diana, Taylor , Verdon, Zhou , Bin Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development. PLoS ONE, 2013-04-01;8(4):e60244. 2013-04-01 [PMID: 23560082] (Bioassay, Mouse)
• Li S, Meyer N, Quarto N, Longaker M Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts. PLoS ONE, 2013-03-25;8(3):e58610. 2013-03-25 [PMID: 23536803] (Bioassay, Mouse)
• Huegel J, Mundy C, Sgariglia F, Nygren P, Billings P, Yamaguchi Y, Koyama E, Pacifici M Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses. Dev Biol, 2013-03-01;377(1):100-12. 2013-03-01 [PMID: 23458899] (Bioassay, Mouse)
• Mehta V, Schmitz C, Keil K, Joshi P, Abler L, Lin T, Taketo M, Sun X, Vezina C Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning. Dev Biol, 2013-02-08;376(2):125-35. 2013-02-08 [PMID: 23396188] (Bioassay, Mouse)
• Tucker B, Anfinson K, Mullins R, Stone E, Young M Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation. Stem Cells Transl Med, 2012-12-27;2(1):16-24. 2012-12-27 [PMID: 23283489] (Bioassay, Mouse)
• Chen , Jiekai, Liu , He, Liu , Jing, Qi , Jing, Wei , Bei, Yang , Jiaqi, Liang , Hanquan, Chen , You, Chen , Jing, Wu , Yaran, Guo , Lin, Zhu , Jieying, Zhao , Xiangjie, Peng , Tianran, Zhang , Yixin, Chen , Shen, Li , Xuejia, Li , Dongwei, Wang , Tao, Pei , Duanqing H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet, 2012-12-02;45(1):34-42. 2012-12-02 [PMID: 23202127] (Bioassay, Mouse)
• Brafman D, Phung C, Kumar N, Willert K Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ, 2012-11-16;20(3):369-81. 2012-11-16 [PMID: 23154389] (Bioassay, Human)
• Sneddon , Julie B, Borowiak , Malgorza, Melton , Douglas Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature, 2012-10-07;491(7426):765-8. 2012-10-07 [PMID: 23041930] (Cell Culture, Human)
• Ueki Y, Reh TA Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo. PLoS ONE, 2012-06-06;7(6):e38690. 2012-06-06 [PMID: 22701694] (In Vivo, Mouse)
• Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature, 2012-04-04;485(7396):104-8. 2012-04-04 [PMID: 22495305] (In Vivo, Mouse)
• Wang P, McKnight K, Wong D, Rodriguez R, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang H, Kim S A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev, 2012-02-29;21(12):2273-87. 2012-02-29 [PMID: 22236333] (Bioassay, Mouse)
• Kawaguchi J, Nichols J, Gierl MS, Faial T, Smith A Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos. Development, 2010-03-01;137(5):693-704. 2010-03-01 [PMID: 20147374] (Bioassay, Mouse)
• Du Y, Xiao Q, Yip HK Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade. Invest. Ophthalmol. Vis. Sci., 2010-02-03;51(7):3764-73. 2010-02-03 [PMID: 20130285] (Bioassay, Mouse)
• Hayashi K, Surani MA Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro. Development, 2009-09-30;136(21):3549-56. 2009-09-30 [PMID: 19793888] (Bioassay, Mouse)
• Sellers DL, Maris DO, Horner PJ Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury. J. Neurosci., 2009-05-20;29(20):6722-33. 2009-05-20 [PMID: 19458241] (In Vivo, Mouse)
• Kelley R, Ren R, Pi X, Wu Y, Moreno I, Willis M, Moser M, Ross M, Podkowa M, Attisano L, Patterson C A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J. Cell Biol., 2009-02-16;184(4):597-609. 2009-02-16 [PMID: 19221194] (Bioassay, Mouse)
• Kobune M, Kawano Y, Takahashi S, Takada K, Murase K, Iyama S, Sato T, Takimoto R, Niitsu Y, Kato J Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells. Exp. Hematol., 2008-06-17;36(9):1121-31. 2008-06-17 [PMID: 18562079] (Bioassay, Human)
• Matsuura I, Taniguchi J, Hata K, Saeki N, Yamashita T BMP inhibition enhances axonal growth and functional recovery after spinal cord injury. J. Neurochem., 2008-01-24;105(4):1471-9. 2008-01-24 [PMID: 18221366] (In Vivo, Rat)
• Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, Yong J, Jiang W, Sun X, DU L, Ding M, Deng H Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood, 2007-11-27;111(4):1933-41. 2007-11-27 [PMID: 18042803] (Bioassay, Human)
• Fuller ML, DeChant AK, Rothstein B, Caprariello A, Wang R, Hall AK, Miller RH Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Ann. Neurol., 2007-09-01;62(3):288-300. 2007-09-01 [PMID: 17696121] (Bioassay, Rat)
• Stavridis MP, Lunn JS, Collins BJ, Storey KG A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification. Development, 2007-08-01;134(16):2889-94. 2007-08-01 [PMID: 17660197] (Bioassay, Mouse)
• Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood, 2007-05-31;110(6):2182-9. 2007-05-31 [PMID: 17540841] (Bioassay, Mouse)
• Tiecke E, Bangs F, Blaschke R, Farrell ER, Rappold G, Tickle C Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements. Dev. Biol., 2006-07-12;298(2):585-96. 2006-07-12 [PMID: 16904661] (In Vivo, Chicken)
• Schlueter J, Manner J, Brand T BMP is an important regulator of proepicardial identity in the chick embryo. Dev. Biol., 2006-04-01;295(2):546-58. 2006-04-01 [PMID: 16677627] (Bioassay, Chicken)
• Maeshima A, Vaughn DA, Choi Y, Nigam SK Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 2006-04-27;295(2):473-85. 2006-04-27 [PMID: 16643884] (Bioassay, Rat)
• Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc. Natl. Acad. Sci. U.S.A., 2006-04-21;103(18):6907-12. 2006-04-21 [PMID: 16632596] (Bioassay, Human)
• Brugmann SA, Pandur PD, Kenyon KL, Pignoni F, Moody SA Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. Development, 2004-11-03;131(23):5871-81. 2004-11-03 [PMID: 15525662] (Bioassay, Xenopus)

Bioinformatics

• Gene Symbol: Nog
• Uniprot:
  • P97466()