Noggin Proteins

314-BP). The dark blue line on the graph is showing the ability of Recombinant Human BMP-4 (ng/mL) to induce alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line." class="big_lightbox"> 314-BP). The dark blue line on the graph is showing the ability of Recombinant Human BMP-4 (ng/mL) to induce alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line." class="big_thumb" />

3718-FB) and Recombinant Human Noggin (Catalog # 6057-NG), along with the other reagents listed in the brain organoid culture recipe. Cerebral organoids were stained for Syto6 (blue), Pax6 (red), and Vimentin (green). (A) Image taken at 4x magnification. (B) An enlarged view of the area shown within the white box in part A of the figure. (C) Image taken at 15x magnification. Images courtesy of LifeCanvas Technologies. " class="big_lightbox"> 3718-FB) and Recombinant Human Noggin (Catalog # 6057-NG), along with the other reagents listed in the brain organoid culture recipe. Cerebral organoids were stained for Syto6 (blue), Pax6 (red), and Vimentin (green). (A) Image taken at 4x magnification. (B) An enlarged view of the area shown within the white box in part A of the figure. (C) Image taken at 15x magnification. Images courtesy of LifeCanvas Technologies. " class="big_thumb" />

brain organoid culture recipe. (A) Representative brightfield image of day 30 iPSC-derived cerebral organoids. (B) Cerebral organoids stained for beta III-tubulin (green) and Prox1 (red), and counterstained with DAPI (blue)." class="big_lightbox"> brain organoid culture recipe. (A) Representative brightfield image of day 30 iPSC-derived cerebral organoids. (B) Cerebral organoids stained for beta III-tubulin (green) and Prox1 (red), and counterstained with DAPI (blue)." class="big_thumb" />

1967-NG) inhibits recombinant human BMP-4-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED₅₀ for this effect is 0.06-0.3 µg/mL in the presence of 50 ng/mL of recombinant human BMP-4 (314-BP)." class="big_lightbox"> 1967-NG) inhibits recombinant human BMP-4-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED₅₀ for this effect is 0.06-0.3 µg/mL in the presence of 50 ng/mL of recombinant human BMP-4 (314-BP)." alt="Recombinant mouse Noggin (1967-NG) inhibits recombinant human BMP-4-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED₅₀ for this effect is 0.06-0.3 µg/mL in the presence of 50 ng/mL of recombinant human BMP-4 (314-BP)." class="big_thumb" />

314-BP)." class="big_lightbox"> 314-BP)." class="big_thumb" />

3344-NG) inhibits recombinant human BMP-4-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED₅₀ for this effect is 0.100-0.400 µg/mL in the presence of 30 ng/mL of recombinant human BMP-4 (314-BP)." class="big_lightbox"> 3344-NG) inhibits recombinant human BMP-4-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED₅₀ for this effect is 0.100-0.400 µg/mL in the presence of 30 ng/mL of recombinant human BMP-4 (314-BP)." alt="Recombinant human Noggin Fc chimera (3344-NG) inhibits recombinant human BMP-4-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED₅₀ for this effect is 0.100-0.400 µg/mL in the presence of 30 ng/mL of recombinant human BMP-4 (314-BP)." class="big_thumb" />

314-BP)." class="big_lightbox"> 314-BP)." alt="Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED₅₀ for this effect is 0.06-0.3 µg/mL in the presence of 30 ng/mL of Recombinant Human BMP-4 (314-BP)." class="big_thumb" />

BT-NOG-GMP), Animal-Free (BT-NOG-AFL) and RUO (Catalog # BT-NOG) grades of Recombinant Human Noggin as measured by their ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells (orange, green, red, respectively)." class="big_lightbox"> BT-NOG-GMP), Animal-Free (BT-NOG-AFL) and RUO (Catalog # BT-NOG) grades of Recombinant Human Noggin as measured by their ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells (orange, green, red, respectively)." alt="Equivalent bioactivity of GMP (BT-NOG-GMP), Animal-Free (BT-NOG-AFL) and RUO (Catalog # BT-NOG) grades of Recombinant Human Noggin as measured by their ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells (orange, green, red, respectively)." class="big_thumb" />

314-BP) induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED₅₀ for this effect is 0.0200-0.240 µg/mL." class="big_lightbox"> 314-BP) induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED₅₀ for this effect is 0.0200-0.240 µg/mL." class="big_thumb" />