WB, IHC, ICC/IFHost:
Species: Hu, Mk
Applications: WB, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Host: Rabbit Polyclonal
Applications: RNAi, RNAi SP
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
Bioinformatics Tool for Noggin
Discover related pathways, diseases and genes to Noggin. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.