Recombinant Mouse IL-9 Protein, CF


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Reactivity MuSpecies Glossary
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Recombinant Mouse IL-9 Protein, CF Summary

Details of Functionality
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. Avanzi, G. et al. (1988) Br. J. Haematol. 69:359. The ED50 for this effect is 0.500-5.00 ng/mL.
Spodoptera frugiperda, Sf 21 (baculovirus)-derived mouse IL-9 protein
Accession #
N-terminal Sequence

No results obtained, sequencing might be blocked: Gln19 is predicted

Protein/Peptide Type
Recombinant Proteins
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


  • Bioactivity
Theoretical MW
14.2 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Multiple bands between 16-25 kDa, reducing conditions
Read Publications using
409-ML/CF in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-9 Protein, CF

  • Cytokine P40
  • HP40
  • IL9
  • IL-9
  • IL-9homolog of mouse T cell and mast cell growth factor 40
  • interleukin 9
  • interleukin-9
  • p40 cytokine
  • p40 T-cell and mast cell growth factor
  • P40
  • T-cell growth factor P40


Interleukin-9 (IL-9), also known as P40 and MEA (mast cell growth-enhancing activity), is a 30-40 kDa glycosylated member of a cytokine family that includes Interleukins-2, -4, -7, -15, and -21. These proteins utilize heteromeric receptors containing the Common gamma chain ( gamma c) in addition to ligand-specific subunits. IL-9 interacts selectively with IL-9 R which then associates with gamma c to form the functional receptor complex. IL-9 contributes to allergic inflammation, autoimmunity-induced inflammation, parasite clearance from the GI tract, and Treg-mediated immune suppression (1, 2). It enhances the expansion and recruitment of mast cells and eosinophils as well as the production of IgE and Th2 cytokines (3‑6). It is required for anaphylactic responses to ingested allergens but not to systemic allergens (7). IL-9 plays multiple roles in the development and function of subsets within the CD4+ T cell lineage (8). It is expressed by activated Th9, Th17, Treg, and Th2 cells (3, 9‑12). IL-9 acts as an autocrine growth and activation factor for Th17, Treg, and mast cells (3, 11, 13). It also can inhibit immune responses by enhancing the suppressive properties of Treg and by recruiting immune-suppressive mast cells to sites of inflammation (11, 12). Mature mouse IL-9 shares 57% and 74% amino acid sequence identity with human and rat IL-9, respectively (14).
  1. Noelle, R.J. and E.C. Nowak (2010) Nat. Rev. Immunol. 10:683.
  2. Goswami, R. and M.H. Kaplan (2011) J. Immunol. 186:3283.
  3. Nowak, E.C. et al. (2009) J. Exp. Med. 206:1653.
  4. Townsend, M.J. et al. (2000) Immunity 13:573.
  5. Leech, M.D. and R.K. Grencis (2006) J. Immunol. 176:2505.
  6. Fawaz, L.M. et al. (2007) J. Allergy Clin. Immunol. 120:1208.
  7. Osterfeld, H. et al. (2010) J. Allergy Clin. Immunol. 125:469.
  8. Jabeen, R. and M.H. Kaplan (2012) Curr. Opin. Immunol. 24:303.
  9. Tan, C. et al. (2010) J. Immunol. 185:6795.
  10. Jager, A. et al. (2009) J. Immunol. 183:7169.
  11. Elyaman, W. et al. (2009) Proc. Natl. Acad. Sci. USA 106:12885.
  12. Lu, L.-F. et al. (2006) Nature 442:997.
  13. Stassen, M. et al. (2000) J. Immunol. 164:5549.
  14. Van Snick, J. et al. (1989) J. Exp. Med. 169:363.

Publications for IL-9 (409-ML/CF)(11)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Bioassay, In Vivo.

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Showing Publications 1 - 10 of 11. Show All 11 Publications.
Publications using 409-ML/CF Applications Species
KM Deng, XS Yang, Q Luo, YX She, QY Yu, XX Tang Deleterious Role of Th9 Cells in Pulmonary Fibrosis Cells, 2021-11-17;10(11):. 2021-11-17 [PMID: 34831433] (Bioassay, Mouse) Bioassay Mouse
T Yashiro, H Ogata, SF Zaidi, J Lee, S Hayashi, T Yamamoto, M Kadowaki Pathophysiological Roles of Neuro-Immune Interactions between Enteric Neurons and Mucosal Mast Cells in the Gut of Food Allergy Mice Cells, 2021-06-23;10(7):. 2021-06-23 [PMID: 34201851] (Bioassay, Mouse) Bioassay Mouse
X Liu, F Zhou, W Wang, G Chen, Q Zhang, R Lv, Z Zhao, X Li, Q Yu, JM Meves, H Hua, X Li, X Wang, H Sun, D Gao IL-9-triggered lncRNA Gm13568 regulates Notch1 in astrocytes through interaction with CBP/P300: contribute to the pathogenesis of experimental autoimmune encephalomyelitis Journal of Neuroinflammation, 2021-05-11;18(1):108. 2021-05-11 [PMID: 33971906] (Bioassay, Mouse) Bioassay Mouse
RR Almeida, RS Vieira, A Castoldi, FF Terra, ACL Melo, MCC Canesso, L Lemos, M Cipelli, N Rana, MI Hiyane, EL Pearce, FDS Martins, AMC Faria, NOS Câmara Host dysbiosis negatively impacts IL-9-producing T-cell differentiation and antitumour immunity Br. J. Cancer, 2020-06-05;0(0):. 2020-06-05 [PMID: 32499569] (Bioassay, Mouse) Bioassay Mouse
N Liu, Y Jiang, J Chen, H Nan, Y Zhao, X Chu, A Wang, D Wang, T Qin, S Gao, Q Yi, Y Yue, S Wang IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells Cell. Mol. Immunol., 2018-10-01;0(0):. 2018-10-01 [PMID: 30275536] (Mouse) Mouse
Turner , Jan-Eric, Morrison , Peter J, Wilhelm , Christop, Wilson , Mark, Ahlfors , Helena, Renauld , Jean-Chr, Panzer , Ulf, Helmby , Helena, Stockinger , Brigitta IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. J Exp Med, 2013-11-18;210(13):2951-65. 2013-11-18 [PMID: 24249111] (Bioassay, Mouse) Bioassay Mouse
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat. Med., 2012-07-08;1248(0):18. 2012-07-08 [PMID: 22772464] (In Vivo, Mouse) In Vivo Mouse
Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse) Bioassay Mouse
Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 2010-09-29;84(24):12703-12. 2010-09-29 [PMID: 20881038] (In Vivo, Mouse) In Vivo Mouse
Vang KB, Yang J, Mahmud SA, Burchill MA, Vegoe AL, Farrar MA IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development. J. Immunol., 2008-09-01;181(5):3285-90. 2008-09-01 [PMID: 18714000] (Bioassay, Mouse) Bioassay Mouse
Show All 11 Publications.

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Gene Symbol Il9