Recombinant Mouse IL-33 Protein

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse IL-33 Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED₅₀ for this effect is 0.0125-0.05 ng/mL.
• Source: E. coli-derived mouse IL-33 protein
  Ser109-Ile266
• Accession #: Q8BVZ5
• N-terminal Sequence: Ser109
• Protein/Peptide Type: Recombinant Proteins
• Gene: Il33
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 18 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 20 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, ≤ -20 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and DTT with BSA as a carrier protein.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-33 Protein

• C9orf26
• C9orf26chromosome 9 open reading frame 26 (NF-HEV)
• DKFZp586H0523
• DVS27
• DVS27-related protein
• IL1F11
• IL-1F11
• IL33
• IL-33
• interleukin 33
• Interleukin-1 family member 11
• interleukin-33
• NFHEV
• NF-HEV
• NF-HEVNFEHEV
• Nuclear factor from high endothelial venules
• RP11-575C20.2

Background

IL-33, also known as NF-HEV and DVS 27, is a 30 kDa proinflammatory protein that may also regulate gene transcription (1‑3). DVS 27 was identifed as a gene that is up‑regulated in vasospastic cerebral arteries (1). NF-HEV was described as a nuclear factor that is preferentially expressed in the endothelial cells of high endothelial venules relative to endothelial cells from other tissues (2). IL-33 was identified based on sequence and structural homology with IL-1 family cytokines (3). DVS 27, NF-HEV, and IL-33 share 100% amino acid sequence identity. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation (1, 3). Similar to IL-1, IL-33 can be cleaved in vitro by caspase‑1, generating an N‑terminal fragment that is slightly shorter than the C‑terminal fragment (3, 4). The N‑terminal portion of full length IL-33 contains a predicted bipartite nuclear localization sequence and a homeodomain-like helix-turn-helix DNA binding domain. By immunofluorescence, full length IL-33 localizes to the nucleus in HUVECs and transfectants (2). The C‑terminal fragment, corresponding to mature IL-33, binds and triggers signaling through mast cell IL‑1 R4/ST2L, a longtime orphan receptor involved in the augmentation of Th2 cell responses (3, 5‑7). A ternary signaling complex is formed by the subsequent association of IL-33 and ST2L with IL‑1 RAcP (8). Stimulation of Th2 polarized lymphocytes with mature IL-33 in vitro induces IL-5 and IL-13 secretion (3). In vivo administration of mature IL-33 promotes increased production of IL-5, IL-13, IgE, and IgA, as well as splenomegaly and inflammatory infiltration of mucosal tissues (3). Full length and mature mouse IL-33 share approximately 55% and 90% aa sequence identity with human and rat IL-33, respectively. Mouse IL-33 shares less than 25% aa sequence identity with other IL-1 family proteins.

1. Onda, H. et al. (1999) J. Cereb. Blood Flow Metab. 19:1279.
2. Baekkevold, E.S. et al. (2003) Am. J. Pathol. 163:69.
3. Schmitz, J. et al. (2005) Immunity 23:479.
4. Black, R.A. et al. (1989) J. Biol. Chem. 264:5323.
5. Xu, D. et al. (1998) J. Exp. Med. 187:787.
6. Lohning, M. et al. (1998) Proc. Natl. Acad. Sci. 95:6930.
7. Dinarello, C.A. (2005) Immunity 23:461.
8. Chackerian, A.A. et al. (2007) J. Immunol. 179:2551.

Publications for IL-33 (3626-ML)(119)

Publications using 3626-ML

• Li, Y;Li, TY;Qiao, Q;Zhang, MT;Tong, MX;Xu, LF;Zhang, ZB; Polymeric immunoglobulin receptor promotes Th2 immune response in the liver by increasing cholangiocytes derived IL-33: a diagnostic and therapeutic biomarker of biliary atresia EBioMedicine 2024-09-16 [PMID: 39288533] (In-vivo, Mouse)
• Bao, K;Gu, X;Song, Y;Zhou, Y;Chen, Y;Yu, X;Yuan, W;Shi, L;Zheng, J;Hong, M; TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma Nature communications 2024-09-08 [PMID: 39245681] (Bioassay, Mouse)
• Zhang, H;Xue, K;Li, W;Yang, X;Gou, Y;Su, X;Qian, F;Sun, L; Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity Nature communications 2024-01-04 [PMID: 38177117] (Bioassay, Mouse)
• Kim, J;Ham, J;Kang, HR;Bae, YS;Kim, T;Kim, HY; JAK3 inhibitor suppresses multipotent ILC2s and attenuates steroid-resistant asthma Science advances 2023-12-22 [PMID: 38117887] (In vivo assay, Mouse)
• Su, HH;Cheng, CM;Yang, YN;Chang, YW;Li, CY;Wu, ST;Lin, CC;Wu, HE;Suen, JL; Acrylamide, an Air Pollutant, Enhances Allergen-Induced Eosinophilic Lung Inflammation via Group 2 Innate Lymphoid Cells Mucosal immunology 2023-10-05 [PMID: 37805143] (Bioassay, Mouse)
• Calafiore, M;Fu, YY;Vinci, P;Arnhold, V;Chang, WY;Jansen, SA;Egorova, A;Takashima, S;Kuttiyara, J;Ito, T;Serody, J;Nakae, S;Turnquist, H;van Es, J;Clevers, H;Lindemans, CA;Blazar, BR;Hanash, AM; A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury Nature communications 2023-09-05 [PMID: 37669929] (Bioassay, Mouse)
• Hollifield, IE;Motyka, NI;Fernando, KA;Bitoun, JP; Heat-Labile Enterotoxin Decreases Macrophage Phagocytosis of Enterotoxigenic Escherichia coli Microorganisms 2023-08-21 [PMID: 37630681] (Bioassay, Mouse)
• Hansakon, A;Jeerawattanawart, S;Angkasekwinai, P; Differential and cooperative effects of IL-25 and IL-33 on T helper cells contribute to cryptococcal virulence and brain infection Scientific reports 2023-06-19 [PMID: 37337050] (Bioassay, Mouse)
• Cho, MJ;Lee, HG;Yoon, JW;Kim, GR;Koo, JH;Taneja, R;Edelson, BT;Lee, YJ;Choi, JM; Steady-state memory-phenotype conventional CD4+ T cells exacerbate autoimmune neuroinflammation in a bystander manner via the Bhlhe40/GM-CSF axis Experimental & molecular medicine 2023-05-01 [PMID: 37121980] (Bioassay, Mouse)
• PH Papotto, B Yilmaz, G Pimenta, S Mensurado, C Cunha, GJ Fiala, D Gomes da C, N Gonçalves-, BHK Chan, B Blankenhau, RG Domingues, T Carvalho, MR Hepworth, AJ Macpherson, JE Allen, B Silva-Sant Maternal gammadelta T�cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner Cell Reports, 2023-02-07;0(0):112074. 2023-02-07 [PMID: 36787741] (Bioassay, In Vivo, Mouse)
• RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu Crosstalk between ILC2s and Th2 cells varies among mouse models Cell Reports, 2023-02-02;42(2):112073. 2023-02-02 [PMID: 36735533] (Bioassay, Mouse)
• L Cheng, Y Jiao, W Jiang, X Zhang, L Zhang, G Jia IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells Journal of Immunology Research, 2022-12-16;2022(0):9543083. 2022-12-16 [PMID: 36570798] (In Vivo, Mouse, Transgenic Mouse)
• M Zhao, F Shao, D Yu, J Zhang, Z Liu, J Ma, P Xia, S Wang Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis Nature Communications, 2022-12-09;13(1):7600. 2022-12-09 [PMID: 36494354] (In Vivo, Mouse)
• KE Block, K Iijima, MJ Pierson, DA Walsh, R Tei, TA Kucaba, J Xu, MH Khan, C Staley, TS Griffith, HJ McSorley, H Kita, SC Jameson Physiological microbial exposure transiently inhibits mouse lung ILC2 responses to allergens Nature Immunology, 2022-11-21;0(0):. 2022-11-21 [PMID: 36411381] (In Vivo, Mouse)
• JH Badrani, AN Strohm, L Lacasa, B Civello, K Cavagnero, YA Haung, M Amadeo, LH Naji, SJ Lund, A Leng, H Kim, RE Baum, N Khorram, M Mondal, G Seumois, J Pilotte, PW Vanderklis, HM McGee, TA Doherty RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R Nature Communications, 2022-07-30;13(1):4435. 2022-07-30 [PMID: 35908044] (In Vivo, Mouse)
• HS Lee, HW Park IL-23 plays a significant role in the augmentation of particulate matter-mediated allergic airway inflammation Journal of Cellular and Molecular Medicine, 2022-07-08;0(0):. 2022-07-08 [PMID: 35801505] (Bioassay, Mouse)
• A Sheikh, J Lu, E Melese, JH Seo, N Abraham IL-7 induces type 2 cytokine response in lung ILC2s and regulates GATA3 and CD25 expression Journal of leukocyte biology, 2022-05-23;0(0):. 2022-05-23 [PMID: 35603486] (Stimulation, Mouse)
• T Doke, A Abedini, DL Aldridge, YW Yang, J Park, CM Hernandez, MS Balzer, R Shrestra, G Coppock, JMI Rico, SY Han, J Kim, S Xin, AM Piliponsky, M Angelozzi, V Lefebvre, MC Siracusa, CA Hunter, K Susztak Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis Nature Immunology, 2022-05-12;0(0):. 2022-05-12 [PMID: 35552540] (Bioassay, Mouse)
• F Cardoso, RGJ Klein Wolt, C Godinho-Si, RG Domingues, H Ribeiro, JA da Silva, I Mahú, AI Domingos, H Veiga-Fern Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit Nature, 2021-08-18;0(0):. 2021-08-18 [PMID: 34408322] (Bioassay, Mouse)
• Y Suzuki, T Hayashi, R Yokoyama, F Nakagawa, J Inoue, T Higashi, R Onodera, K Motoyama Fasting impairs type 2 helper T cell infiltration in the lung of an eosinophilic asthma mouse model FEBS Open Bio, 2021-08-20;0(0):. 2021-08-20 [PMID: 34363652] (Bioassay, Mouse)
• S Patial, BW Lewis, T Vo, I Choudhary, K Paudel, Y Mao, D Singamsett, F Brombacher, Y Saini Myeloid-IL4Ralpha is an indispensable link in IL-33-ILCs-IL-13-IL4Ralpha axis of eosinophil recruitment in murine lungs Scientific Reports, 2021-07-29;11(1):15465. 2021-07-29 [PMID: 34326406] (Bioassay, Mouse)
• P de Lucía F, C Sherwood, I Saranchova, W Xia, L Munro, CG Pfeifer, JM Piret, WA Jefferies Serum free culture for the expansion and study of type 2 innate lymphoid cells Scientific Reports, 2021-06-10;11(1):12233. 2021-06-10 [PMID: 34112824] (In Vivo, Mouse)
• D Morichika, A Taniguchi, N Oda, U Fujii, S Senoo, J Itano, A Kanehiro, Y Kitaguchi, M Yasuo, M Hanaoka, T Satoh, S Akira, K Kiura, Y Maeda, N Miyahara Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice Respiratory Research, 2021-05-15;22(1):150. 2021-05-15 [PMID: 33992109] (Bioassay, Mouse)
• ME Kotas, J Dion, S Van Dyken, RR Ricardo-Go, CJ Danel, C Taillé, L Mouthon, RM Locksley, B Terrier A role for IL-33-activated ILC2s in eosinophilic vasculitis JCI Insight, 2021-06-22;0(0):. 2021-06-22 [PMID: 33974563] (Bioassay, Mouse)
• C Zheng, Z Lu, H Wu, L Cui, J Bi, X Wan Exogenous oxidative stress suppresses IL-33 -driven proliferation programming in group 2 innate lymphoid cells International immunopharmacology, 2021-03-20;95(0):107541. 2021-03-20 [PMID: 33756232] (Bioassay, Mouse)
• K Arae, M Ikutani, K Horiguchi, S Yamaguchi, Y Okada, H Sugiyama, K Orimo, H Morita, H Suto, K Okumura, H Taguchi, K Matsumoto, H Saito, K Sudo, S Nakae Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin Scientific Reports, 2021-03-15;11(1):5913. 2021-03-15 [PMID: 33723298] (Bioassay, Mouse)
• D Alonso-Cur, YJ Ho, C Burdziak, JLV Maag, JP Morris, R Chandwani, HA Chen, KM Tsanov, FM Barriga, W Luan, N Tasdemir, G Livshits, E Azizi, J Chun, JE Wilkinson, L Mazutis, SD Leach, R Koche, D Pe'er, SW Lowe A gene-environment-induced epigenetic program initiates tumorigenesis Nature, 2021-02-03;0(0):. 2021-02-03 [PMID: 33536616] (Bioassay, Mouse)
• B Baban, M Braun, H Khodadadi, A Ward, K Alverson, A Malik, K Nguyen, S Nazarian, DC Hess, S Forseen, AF Post, FL Vale, JR Vender, MN Hoda, O Akbari, K Vaibhav, KM Dhandapani AMPK induces regulatory innate lymphoid cells after traumatic brain injury JCI Insight, 2021-01-11;6(1):. 2021-01-11 [PMID: 33427206] (In Vivo, Mouse, Transgenic Mouse)
• J Huang, MA Gandini, L Chen, S M'Dahoma, PL Stemkowski, H Chung, DA Muruve, GW Zamponi Hyperactivity of Innate Immunity Triggers Pain via TLR2-IL-33-Mediated Neuroimmune Crosstalk Cell Rep, 2020-10-06;33(1):108233. 2020-10-06 [PMID: 33027646] (Bioassay, Mouse)
• F Reverchon, V de Concini, V Larrigaldi, S Benmerzoug, S Briault, D Togbé, B Ryffel, VFJ Quesniaux, A Menuet Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments J Neuroinflammation, 2020-09-11;17(1):268. 2020-09-11 [PMID: 32917228] (Bioassay, Mouse)
• JM Inclan-Ric, JJ Ponessa, N Valero-Pac, CM Hernandez, CB Sy, AD Lemenze, AM Beaulieu, MC Siracusa Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition Nat. Immunol., 2020-08-17;0(0):. 2020-08-17 [PMID: 32807943] (Bioassay, Mouse)
• Bosteels C, Neyt K, Vanheerswynghels M, van Helden M, Sichien D, Debeuf N, De Prijck S, Bosteels V, Vandamme N, Martens L, Saeys Y, Louagie E, Lesage M, Williams D, Tang S, Mayer J, Ronchese F, Scott C, Hammad H, Guilliams M, Lambrecht B Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection. Immunity, 2020-05-08;0(0):. 2020-05-08 [PMID: 32392463] (Mouse)
• K Takenaga, M Akimoto, N Koshikawa, H Nagase Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model PLoS ONE, 2020-04-27;15(4):e0232230. 2020-04-27 [PMID: 32340025] (Cell Culture, Mouse)
• A Vasanthaku, D Chisanga, J Blume, R Gloury, K Britt, DC Henstridge, Y Zhan, SV Torres, S Liene, N Collins, E Cao, T Sidwell, C Li, RG Spallanzan, Y Liao, PA Beavis, T Gebhardt, N Trevaskis, SL Nutt, JD Zajac, RA Davey, MA Febbraio, D Mathis, W Shi, A Kallies Sex-specific adipose tissue imprinting of regulatory T cells Nature, 2020-02-26;0(0):. 2020-02-26 [PMID: 32103173] (In Vivo, Mouse)
• M Wagner, KN Ealey, H Tetsu, T Kiniwa, Y Motomura, K Moro, S Koyasu Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s Cell Rep, 2020-02-25;30(8):2743-2757.e5. 2020-02-25 [PMID: 32101749] (Bioassay, In Vivo, Mouse)
• L Lin, X Tang, Z Chen, J Wei, F Dai, G Sun Nuocytes from mesenteric lymph node promote allergic responses in a mouse model Braz J Otorhinolaryngol, 2020-02-12;0(0):. 2020-02-12 [PMID: 32098719] (In Vivo, Mouse)
• JA Moral, J Leung, LA Rojas, J Ruan, J Zhao, Z Sethna, A Ramnarain, B Gasmi, M Gururajan, D Redmond, G Askan, U Bhanot, E Elyada, Y Park, DA Tuveson, M Gönen, SD Leach, JD Wolchok, RP DeMatteo, T Merghoub, VP Balachandr ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity Nature, 2020-02-19;0(0):. 2020-02-19 [PMID: 32076273] (In Vivo, Mouse)
• CL Hsu, KD Chhiba, R Krier-Burr, S Hosakoppal, S Berdnikovs, ML Miller, PJ Bryce Allergic inflammation is initiated by IL-33-dependent crosstalk between mast cells and basophils PLoS ONE, 2020-01-15;15(1):e0226701. 2020-01-15 [PMID: 31940364] (Bioassay, Mouse)
• H Miki, S Tahara-Han, MS Almeida, K Hitomi, S Shibagaki, K Kanemaru, YH Lin, K Iwata, S Miyake, S Shibayama, T Sumida, K Shibuya, A Shibuya Allergin-1 Immunoreceptor Suppresses House Dust Mite-Induced Allergic Airway Inflammation J. Immunol., 2020-01-03;204(4):753-762. 2020-01-03 [PMID: 31900344] (Bioassay, Mouse)
• OO Oyesola, C Duque, LC Huang, EM Larson, SP Früh, LM Webb, SA Peng, ED Tait Wojno The Prostaglandin D2 Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung J. Immunol., 2020-01-03;204(4):1001-1011. 2020-01-03 [PMID: 31900341] (In Vivo, Mouse)
• K Ishimaru, S Nakajima, G Yu, Y Nakamura, A Nakao The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock Int J Mol Sci, 2019-12-14;20(24):. 2019-12-14 [PMID: 31847374] (Bioassay, Mouse)
• PT Mantani, P Dunér, I Ljungcrant, J Nilsson, H Björkbacka, GN Fredrikson ILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions BMC Immunol., 2019-12-10;20(1):47. 2019-12-10 [PMID: 31823769] (Bioassay, Mouse)
• Y Mishima, H Sonoyama, S Ishihara, N Oshima, I Moriyama, K Kawashima, Y Kinoshita Interleukin-33 delays recovery of mucosal inflammation via downregulation of homeostatic ABCG5/8 in the colon Lab. Invest., 2019-10-22;0(0):. 2019-10-22 [PMID: 31641224] (In Vivo, Mouse)
• T Sasaki, K Moro, T Kubota, N Kubota, T Kato, H Ohno, S Nakae, H Saito, S Koyasu Innate Lymphoid Cells in the Induction of Obesity Cell Rep, 2019-07-02;28(1):202-217.e7. 2019-07-02 [PMID: 31269440] (Bioassay, Mouse)
• A Zychlinsky, M Rousseau, L Lacerda Ma, T Canton, CR Consiglio, ML Albert, M Fontes, D Duffy, MA Ingersoll Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection JCI Insight, 2019-05-30;5(0):. 2019-05-30 [PMID: 31145099] (In Vivo, Mouse)
• C Symowski, D Voehringer Th2 cell-derived IL-4/IL-13 promote ILC2 accumulation in the lung by ILC2-intrinsic STAT6 signaling in mice Eur. J. Immunol., 2019-06-05;0(0):. 2019-06-05 [PMID: 31144294] (Bioassay, Mouse)
• C Morales De, JR Maxwell, MM Xu, A Menoret, P Mittal, N Tsurutani, AJ Adler, AT Vella Costimulation Induces CD4�T Cell Antitumor Immunity via an Innate-like Mechanism Cell Rep, 2019-04-30;27(5):1434-1445.e3. 2019-04-30 [PMID: 31042471] (Bioassay, Mouse)
• H Katsura, Y Kobayashi, PR Tata, BLM Hogan IL-1 and TNF? Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration Stem Cell Reports, 2019-03-28;0(0):. 2019-03-28 [PMID: 30930244] (Bioassay, Mouse)
• HS Cho, A Reboldi, JA Hall, LJ Berg The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine Nat Commun, 2019-02-15;10(1):784. 2019-02-15 [PMID: 30770814] (Bioassay, Mouse)
• EO Weinberg, B Ferran, Y Tsukahara, MMS Hatch, J Han, CE Murdoch, R Matsui IL-33 induction and signaling are controlled by glutaredoxin-1 in mouse macrophages PLoS ONE, 2019-01-25;14(1):e0210827. 2019-01-25 [PMID: 30682073] (Bioassay, Mouse)
• V Koliaraki, N Chalkidi, A Henriques, C Tzaferis, A Polykratis, A Waisman, W Muller, DJ Hackam, M Pasparakis, G Kollias Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis Cell Rep, 2019-01-15;26(3):536-545.e4. 2019-01-15 [PMID: 30650348] (Bioassay, Mouse)
• R Uchida, H Xiang, H Arai, H Kitamura, K Nishida L-type calcium channel-mediated Zinc wave is involved in the regulation of IL-6 by stimulating non-IgE with LPS and IL-33 in mast cells and dendritic cells Biol. Pharm. Bull., 2018-11-10;0(0):. 2018-11-10 [PMID: 30416166] (Flow Cytometry, Mouse)
• KJ Filbey, M Camberis, J Chandler, R Turner, AJ Kettle, RM Eichenberg, P Giacomin, G Le Gros Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites Mucosal Immunol, 2018-11-06;0(0):. 2018-11-06 [PMID: 30401814] (Bioassay, In Vivo, Mouse)
• N Liu, Y Jiang, J Chen, H Nan, Y Zhao, X Chu, A Wang, D Wang, T Qin, S Gao, Q Yi, Y Yue, S Wang IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells Cell. Mol. Immunol., 2018-10-01;0(0):. 2018-10-01 [PMID: 30275536] (Bioassay, Mouse)
• RR Ricardo-Go, SJ Van Dyken, C Schneider, J Lee, JC Nussbaum, HE Liang, D Vaka, WL Eckalbar, AB Molofsky, DJ Erle, RM Locksley Tissue signals imprint ILC2 identity with anticipatory function Nat. Immunol., 2018-09-10;0(0):. 2018-09-10 [PMID: 30201992] (Bioassay, Mouse)
• SK Varanasi, NK Rajasagi, U Jaggi, BT Rouse Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions Mucosal Immunol, 2018-08-07;0(0):. 2018-08-07 [PMID: 30087443] (Bioassay, Mouse)
• K Cao, X Liao, J Lu, S Yao, F Wu, X Zhu, D Shi, S Wen, L Liu, H Zhou IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation J Neuroinflammation, 2018-05-04;15(1):136. 2018-05-04 [PMID: 29728120] (Bioassay, Mouse)
• T Kobori, S Hamasaki, A Kitaura, Y Yamazaki, T Nishinaka, A Niwa, S Nakao, H Wake, S Mori, T Yoshino, M Nishibori, H Takahashi Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis Front Immunol, 2018-03-06;9(0):334. 2018-03-06 [PMID: 29559970] (Bioassay, Mouse)
• B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao Characterization and allergic role of IL-33-induced neutrophil polarization Cell. Mol. Immunol., 2018-03-05;0(0):. 2018-03-05 [PMID: 29503441] (Bioassay, Mouse)
• G An, X Zhang, W Wang, Q Huang, Y Li, S Shan, CJ Corrigan, W Wang, S Ying The effects of IL-33 on airways collagen deposition and matrix metalloproteinase expression in a murine surrogate of asthma Immunology, 2018-02-18;0(0):. 2018-02-18 [PMID: 29455466] (Bioassay, In Vivo, Mouse)
• Q Li, D Li, X Zhang, Q Wan, W Zhang, M Zheng, L Zou, C Elly, JH Lee, YC Liu E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor Immunity, 2018-02-13;0(0):. 2018-02-13 [PMID: 29452935] (Bioassay, Mouse)
• I Nishioka, T Takai, N Maruyama, S Kamijo, P Suchiva, M Suzuki, S Kunimine, H Ochi, S Shimura, K Sudo, H Ogawa, K Okumura, S Ikeda Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation J. Allergy Clin. Immunol., 2018-02-06;0(0):. 2018-02-06 [PMID: 29426602] (Cell Culture, Mouse)
• M Yamaguchi, SK Samuchiwal, O Quehenberg, JA Boyce, B Balestrier Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms Mucosal Immunol, 2017-12-20;11(3):615-626. 2017-12-20 [PMID: 29346348] (Bioassay, In Vivo, Mouse)
• J Duffen, M Zhang, K Masek-Hamm, A Nunez, A Brennan, JEC Jones, J Morin, K Nocka, M Kasaian Modulation of the IL-33/IL-13 Axis in Obesity by IL-13R?2 J. Immunol., 2018-01-05;0(0):. 2018-01-05 [PMID: 29305434] (In Vivo, Mouse)
• V Cardoso, J Chesné, H Ribeiro, B García-Cas, T Carvalho, T Bouchery, K Shah, NL Barbosa-Mo, N Harris, H Veiga-Fern Neuronal regulation of type 2 innate lymphoid cells via neuromedin U Nature, 2017-09-06;549(7671):277-281. 2017-09-06 [PMID: 28869974] (Bioassay, Mouse)
• JM Garth, KM Reeder, MS Godwin, JJ Mackel, CW Dunaway, JP Blackburn, C Steele IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection J. Immunol., 2017-08-07;199(6):2140-2148. 2017-08-07 [PMID: 28784844] (In Vivo, Mouse)
• M Han, C Rajput, JY Hong, J Lei, JL Hinde, Q Wu, JK Bentley, MB Hershenson The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice J. Immunol., 2017-07-12;0(0):. 2017-07-12 [PMID: 28701507] (Bioassay, Mouse)
• S Taylor, Y Huang, G Mallett, C Stathopoul, TC Felizardo, MA Sun, EL Martin, N Zhu, EL Woodward, MS Elias, J Scott, NJ Reynolds, WE Paul, DH Fowler, S Amarnath PD-1 regulates KLRG1(+) group 2 innate lymphoid cells J. Exp. Med., 2017-05-10;0(0):. 2017-05-10 [PMID: 28490441] (In Vivo, Mouse)
• F Reverchon, S Mortaud, M Sivoyon, I Maillet, A Laugeray, J Palomo, C Montécot, A Herzine, S Meme, W Meme, F Erard, B Ryffel, A Menuet, VFJ Quesniaux IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria PLoS Pathog., 2017-04-27;13(4):e1006322. 2017-04-27 [PMID: 28448579] (Bioassay, Mouse)
• T Sezaki, Y Hirata, T Hagiwara, YI Kawamura, T Okamura, R Takanashi, K Nakano, M Tamura-Nak, LC Burkly, T Dohi Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice World J. Gastroenterol., 2017-04-07;23(13):2294-2307. 2017-04-07 [PMID: 28428709] (Bioassay, Mouse)
• M Ikutani, K Tsuneyama, M Kawaguchi, J Fukuoka, F Kudo, S Nakae, M Arita, Y Nagai, S Takaki, K Takatsu Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy JCI Insight, 2017-04-06;2(7):e90721. 2017-04-06 [PMID: 28405615] (In Vivo, Mouse)
• J Bi, L Cui, G Yu, X Yang, Y Chen, X Wan NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells J. Immunol, 2017-03-08;0(0):. 2017-03-08 [PMID: 28275135] (Bioassay, Mouse)
• M Abad, H Hashimoto, H Zhou, MG Morales, B Chen, R Bassel-Dub, EN Olson Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity Stem Cell Reports, 2017-03-02;0(0):. 2017-03-02 [PMID: 28262548] (Bioassay, Mouse)
• Z Tan, Q Liu, R Jiang, L Lv, SS Shoto, I Maillet, V Quesniaux, J Tang, W Zhang, B Sun, B Ryffel Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells Cell. Mol. Immunol, 2017-02-13;0(0):. 2017-02-13 [PMID: 28194023] (In Vivo, Mouse)
• Jakob von Moltke Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s J. Exp. Med, 2016-12-23;0(0):. 2016-12-23 [PMID: 28011865] (In Vivo, Mouse)
• Interleukin-33 and RANK-L Interplay in the Alveolar Bone Loss Associated to Periodontitis PLoS ONE, 2016-12-19;11(12):e0168080. 2016-12-19 [PMID: 27992569] (Bioassay, Mouse)
• Basophils promote tumor rejection via chemotaxis and infiltration of CD8+ T cells Cancer Res., 2016-11-22;0(0):. 2016-11-22 [PMID: 27879269] (Bioassay, Mouse)
• Gisa Tiegs A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis J. Immunol., 2016-11-21;0(0):. 2016-11-21 [PMID: 27872212] (In Vivo, Mouse)
• IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy Proc. Natl. Acad. Sci. U.S.A., 2016-11-07;0(0):. 2016-11-07 [PMID: 27821781] (Neutralization, Mouse)
• In Vivo Expansion of Activated Foxp3+ Regulatory T Cells and Establishment of a Type 2 Immune Response upon IL-33 Treatment Protect against Experimental Arthritis J Immunol, 2016-07-29;0(0):. 2016-07-29 [PMID: 27474075] (Bioassay, Mouse)
• IL-33 Contributes to Schistosoma japonicum-induced Hepatic Pathology through Induction of M2 Macrophages Sci Rep, 2016-07-21;6(0):29844. 2016-07-21 [PMID: 27445267] (Bioassay, Mouse)
• Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence Nature, 2016-07-13;535(7612):440-3. 2016-07-13 [PMID: 27409807] (Bioassay, Mouse)
• Kempuraj D, Thangavel R, Yang E, Pattani S, Zaheer S, Santillan D, Santillan M, Zaheer A Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins alpha-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators. PLoS ONE, 2015-08-14;10(8):e0135776. 2015-08-14 [PMID: 26275153] (Bioassay, Mouse)
• Monticelli L, Osborne L, Noti M, Tran S, Zaiss D, Artis D IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions. Proc Natl Acad Sci U S A, 2015-08-04;112(34):10762-7. 2015-08-04 [PMID: 26243875] (In Vivo, Mouse)
• Mohapatra A, Van Dyken S, Schneider C, Nussbaum J, Liang H, Locksley R Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. Mucosal Immunol, 2015-07-01;9(1):275-86. 2015-07-01 [PMID: 26129648] (In Vivo, Western Blot, Mouse)
• Nabekura T, Girard J, Lanier L IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection. J Immunol, 2015-04-29;194(12):5948-52. 2015-04-29 [PMID: 25926677] (Bioassay, Mouse)
• Yamada K, Barker T, Dyer K, Rice T, Percopo C, Garcia-Crespo K, Cho S, Lee J, Druey K, Rosenberg H Eosinophil-associated ribonuclease 11 is a macrophage chemoattractant. J Biol Chem, 2015-02-20;290(14):8863-75. 2015-02-20 [PMID: 25713137] (In Vivo, Mouse)
• Brestoff , Jonathan, Kim , Brian S, Saenz , Steven A, Stine , Rachel R, Monticelli , Laurel A, Sonnenberg , Gregory, Thome , Joseph J, Farber , Donna L, Lutfy , Kabirull, Seale , Patrick, Artis , David Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature, 2014-12-22;519(7542):242-6. 2014-12-22 [PMID: 25533952] (In Vivo, Mouse)
• Rizvi S, Mertens J, Bronk S, Hirsova P, Dai H, Roberts L, Kaufmann S, Gores G Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis. J Biol Chem, 2014-06-27;289(33):22835-49. 2014-06-27 [PMID: 24973208] (In Vivo, Mouse)
• Hara K, Iijima K, Elias M, Seno S, Tojima I, Kobayashi T, Kephart G, Kurabayashi M, Kita H Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. J Immunol, 2014-03-24;192(9):4032-42. 2014-03-24 [PMID: 24663677] (In Vivo, Mouse)
• McSorley H, Blair N, Smith K, McKenzie A, Maizels R Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy. Mucosal Immunol, 2014-02-05;7(5):1068-78. 2014-02-05 [PMID: 24496315] (In Vivo, Mouse)
• Yu , X, Pappu , R, Ramirez-Carrozzi , V, Ota , N, Caplazi , P, Zhang , J, Yan , D, Xu , M, Lee , W P, Grogan , J L TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers. Mucosal Immunol, 2013-11-13;7(3):730-40. 2013-11-13 [PMID: 24220298] (Bioassay, In Vivo, Mouse)
• Palm N, Rosenstein R, Yu S, Schenten D, Florsheim E, Medzhitov R Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity, 2013-10-24;39(5):976-85. 2013-10-24 [PMID: 24210353] (Bioassay, Mouse)
• Jovanovic I, Pejnovic N, Radosavljevic G, Pantic J, Milovanovic M, Arsenijevic N, Lukic M Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells. Int J Cancer, 2013-10-10;134(7):1669-82. 2013-10-10 [PMID: 24105680] (In Vivo, Mouse)
• Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity, 2013-09-26;39(4):722-32. 2013-09-26 [PMID: 24076050] (Bioassay, Mouse)
• Tung , Hui-Ying, Plunkett , Beverly, Huang , Shau-Ku, Zhou , Yufeng Murine mast cells secrete and respond to interleukin-33. J Interferon Cytokine Res, 2013-09-12;34(3):141-7. 2013-09-12 [PMID: 24028396] (Bioassay, Mouse)
• Yang Z, Grinchuk V, Urban J, Bohl J, Sun R, Notari L, Yan S, Ramalingam T, Keegan A, Wynn T, Shea-Donohue T, Zhao A Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity. 2013-03-25;0(0):. 2013-03-25 [PMID: 23536877] (In Vivo, Mouse)
• Sandig H, Jobbings C, Roldan N, Whittingham-Dowd J, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation. Eur J Immunol, 2013-03-06;43(4):979-88. 2013-03-06 [PMID: 23404570] (Bioassay, Mouse)
• Mizutani N, Nabe T, Yoshino S Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice. Immunology, 2013-06-01;139(2):205-18. 2013-06-01 [PMID: 23323935] (In Vivo, Mouse)
• Kaieda S, Wang J, Shnayder R, Fishgal N, Hei H, Lee R, Stevens R, Nigrovic P Interleukin-33 primes mast cells for activation by IgG immune complexes. PLoS ONE, 2012-10-11;7(10):e47252. 2012-10-11 [PMID: 23071771] (Bioassay, Mouse)
• Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J. Exp. Med., 2012-07-16;209(8):1505-17. 2012-07-16 [PMID: 22802353] (Bioassay, Mouse)
• Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)
• Wolterink RG, KleinJan A, van Nimwegen M, Bergen I, de Bruijn M, Levani Y, Hendriks RW Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma. Eur. J. Immunol., 2012-05-01;42(5):1106-16. 2012-05-01 [PMID: 22539286] (In Vivo, Mouse)
• Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J. Immunol., 2012-04-13;188(10):4866-75. 2012-04-13 [PMID: 22504644] (Bioassay, Mouse)
• Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J. Immunol., 2011-12-23;188(3):1503-13. 2011-12-23 [PMID: 22198948] (Bioassay, In Vivo, Mouse)
• Monticelli LA, Sonnenberg GF, Abt MC Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat. Immunol., 2011-11-01;12(11):1045-54. 2011-11-01 [PMID: 21946417] (Bioassay, Mouse)
• Anthony RM, Kobayashi T, Wermeling F, Ravetch JV Intravenous gammaglobulin suppresses inflammation through a novel Th2 pathway. Nature, 2011-06-19;475(7354):110-3. 2011-06-19 [PMID: 21685887] (In Vivo, Mouse)
• Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur. J. Immunol., 2011-05-25;41(6):1675-86. 2011-05-25 [PMID: 21469105] (Bioassay, Mouse)
• Louten J, Rankin AL, Li Y Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation. Int. Immunol., 2011-03-21;23(5):307-15. 2011-03-21 [PMID: 21422152] (In Vivo, Mouse)
• Yasuoka S, Kawanokuchi J, Parajuli B, Jin S, Doi Y, Noda M, Sonobe Y, Takeuchi H, Mizuno T, Suzumura A Production and functions of IL-33 in the central nervous system. Brain Res., 2011-02-22;1385(0):8-17. 2011-02-22 [PMID: 21349253] (Bioassay, Mouse)
• Bourgeois EA, Levescot A, Diem S, Chauvineau A, Berges H, Milpied P, Lehuen A, Damotte D, Gombert JM, Schneider E, Girard JP, Gourdy P, Herbelin A A natural protective function of invariant NKT cells in a mouse model of innate-cell-driven lung inflammation. Eur. J. Immunol., 2011-01-11;41(2):299-305. 2011-01-11 [PMID: 21268000] (In Vivo, Mouse)
• Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 2010-09-29;84(24):12703-12. 2010-09-29 [PMID: 20881038] (In Vivo, Mouse)
• Price AE, Liang HE, Sullivan BM Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc. Natl. Acad. Sci. U.S.A., 2010-06-07;107(25):11489-94. 2010-06-07 [PMID: 20534524] (In Vivo, Mouse)
• Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, Bucks C, Kane CM, Fallon PG, Pannell R, Jolin HE, McKenzie AN Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature, 2010-03-03;464(7293):1367-70. 2010-03-03 [PMID: 20200518] (In Vivo, Mouse)
• Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages. J. Immunol., 2009-12-15;183(12):7890-7. 2009-12-15 [PMID: 19933859] (Bioassay, ELISA (Standard), Mouse)
• Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, Nair MG, Du Y, Zaph C, Van Rooijen N, Comeau MR, Pearce EJ, Laufer TM, Artis D MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat. Immunol., 2009-05-24;10(7):697-705. 2009-05-24 [PMID: 19465906] (In Vivo, Mouse)
• Bourgeois E, Van LP, Samson M, Diem S, Barra A, Roga S, Gombert JM, Schneider E, Dy M, Gourdy P, Girard JP, Herbelin A The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production. Eur. J. Immunol., 2009-04-01;39(4):1046-55. 2009-04-01 [PMID: 19266498] (Bioassay, Mouse)
• Palmer G, Talabot-Ayer D, Lamacchia C, Toy D, Seemayer CA, Viatte S, Finckh A, Smith DE, Gabay C Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis. Arthritis Rheum., 2009-03-01;60(3):738-49. 2009-03-01 [PMID: 19248109] (Bioassay, Mouse)
• Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT Induction of IL-33 expression and activity in central nervous system glia. J. Leukoc. Biol., 2008-06-13;84(3):631-43. 2008-06-13 [PMID: 18552204] (Bioassay, ELISA (Standard), Mouse)

Bioinformatics

• Gene Symbol: Il33
• Uniprot:
  • Q8BVZ5()