IL-33 Products

Description

Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine and intracellular nuclear factor with transcriptional regulatory properties. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.

Bioinformatics

Entrez	361749 Rat 77125 Mouse 90865 Human
Uniprot	NM_033439 Human NM-033439 Human NP_254274 Human NP_254274.1 Human O95760 Human
Product By Gene ID	90865
Alternate Names	C9orf26chromosome 9 open reading frame 26 (NF-HEV) DKFZp586H0523 DVS27 DVS27-related protein IL1F11 IL-1F11 IL-33 interleukin 33 Interleukin-1 family member 11 interleukin-33 NFHEV NF-HEVNFEHEV Nuclear factor from high endothelial venules RP11-575C20.2

Related IL-33 Blog Posts

Check out the latest blog posts on IL-33.

Interleukin 33 (IL-33) - A dual function cytokine IL-33 is a member of the interleukin family of cytokines that regulates a wide variety of cellular functions. Its receptor is ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and the IL-1R accessory ...    Read more.

Read more IL-33 related blogs.