WB, IHC, B/N, CyTOF-ready, ELISA(Cap), Flow, ICC/IFHost:
WB, IHC, B/N, ELISA(Cap), ICC/IFHost:
WB, CyTOF-ready, Flow, ICC/IFHost:
Func, PAGE, Bioactivity
Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine and intracellular nuclear factor with transcriptional regulatory properties. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.
|Product By Gene ID
- Nuclear factor from high endothelial venules
- Interleukin-1 family member 11
- DVS27-related protein
- C9orf26chromosome 9 open reading frame 26 (NF-HEV)
- interleukin 33
Bioinformatics Tool for IL-33
Discover related pathways, diseases and genes to IL-33. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.
Related IL-33 Blog Posts
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|Interleukin 33 (IL-33) - A dual function cytokine
IL-33 is a member of the interleukin family of cytokines that regulates a wide variety of cellular functions. Its receptor is ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and the IL-1R accessory... Read more.