Recombinant Mouse IL-17A Protein


There are currently no images for IL-17/IL-17A (421-ML).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity MuSpecies Glossary
Applications Bioactivity

Order Details

View Available Formulations

Recombinant Mouse IL-17A Protein Summary

Additional Information
A New and Improved rm IL-17A is now available! It is CHO expressed and has a lower endotoxin specification!
Details of Functionality
Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. Yao, Z. et al. (1995) Immunity 3:811. The ED50 for this effect is 0.25-1.25 ng/mL.
E. coli-derived mouse IL-17/IL-17A protein
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
15.5 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publications using
421-ML in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 25 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-17A Protein

  • CTLA8
  • CTLA-8
  • CTLA8cytotoxic T-lymphocyte-associated serine esterase 8
  • Cytotoxic T-lymphocyte-associated antigen 8
  • IL17
  • IL-17
  • IL17A
  • IL-17A
  • IL-17Acytotoxic T-lymphocyte-associated protein 8
  • IL-17CTLA-8
  • IL17interleukin-17A
  • interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
  • interleukin 17A


Interleukin-17A (IL-17A), also known as CTLA-8, is a 15-20 kDa glycosylated cytokine that plays an important role in anti-microbial and chronic inflammation. The six IL-17 cytokines (IL-17A-F) are encoded by separate genes but adopt a conserved cystine knot fold (1, 2). Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively (3, 4). IL-17A is secreted by Th17 cells, gamma /δ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells (2). It forms disulfide-linked homodimers as well as disulfide-linked heterodimers with IL-17F (5, 6). IL-17A exerts its effects through the transmembrane IL-17RA in complex with IL-17RC or IL-17RD (7, 8). Both IL-17RA and IL-17RC are required for responsiveness to heterodimeric IL-17A/F (7). IL-17A promotes protective mucosal and epidermal inflammation in response to microbial infection (9-12). It induces chemokine production, neutrophil influx, and the production of antibacterial peptides (9-11). IL-17A/F likewise induces neutrophil migration, but IL-17F does not (11). IL-17A additionally enhances the production of inflammatory mediators by rheumatoid synovial fibroblasts and contributes to TNF-alpha induced shock (Fossiez, 14). In contrast, it can protect against the progression of colitis by limiting chronic inflammation (12). IL-17A encourages the formation of autoreactive germinal centers and exacerbates the onset and progression of experimental models of autoimmunity (15, 16). IL‑17A has been shown to exert either tumorigenic or anti-tumor effects (17, 18).
  1. Gaffen, S.L. (2009) Nat. Rev. Immunol. 9:556.
  2. Cua, D.J. and C.M. Tato (2010) Nat. Rev. Immunol. 10:479.
  3. Yao, Z. et al. (1996) Gene 168:223.
  4. Rouvier, E. et al. (1993) J. Immunol. 150:5445.
  5. Chang, S.H. and C. Dong (2007) Cell Res. 17:435.
  6. Wright, J.F. et al. (2007) J. Biol. Chem. 282:13447.
  7. Wright, J.F. et al. (2008) J. Immunol. 181:2799.
  8. Rong, Z. et al. (2009) Cell Res. 19:208.
  9. Cho, J.S. et al. (2010) J. Clin. Invest. 120:1762.
  10. Liang, S.C. et al. (2006) J. Exp. Med. 203:2271.
  11. Liang, S.C. et al. (2007) J. Immunol. 179:7791.
  12. O’Connor Jr., W. et al. (2009) Nat. Immunol. 10:603.
  13. Fossiez, F. et al. (1996) J. Exp. Med. 183:2593.
  14. Takahashi, N. et al. (2008) J. Exp. Med. 205:1755.
  15. Hsu, H. et al. (2008) Nat. Immunol. 9:166.
  16. Rohn, T.A. et al. (2006) Eur. J. Immunol. 36:2857.
  17. Wang, L. et al. (2009) J. Exp. Med. 206:1457.
  18. Kryczek, I. et al. (2009) Blood 114:357.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu, Rt, Ca, Rb
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu
Applications: WB, IHC, CyTOF-ready, ICFlow
Species: Hu, Mu, Rt, Bv
Applications: WB, Flow, IB, ICC/IF, IHC, IHC-P, IP, Single-Cell Western
Species: Hu
Applications: WB, Flow, CyTOF-ready, KO, Neut
Species: Mu, Rt
Applications: Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Cell Depl, CyTOF-ready, InhibTFunc
Species: Mu
Applications: Bioactivity

Publications for IL-17/IL-17A (421-ML)(75)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Bacteria.

We have publications tested in 4 applications: Bioassay, ELISA (Standard), In Vivo, In-Vivo.

Filter By Application
ELISA (Standard)
In Vivo
All Applications
Filter By Species
All Species
Showing Publications 1 - 10 of 75. Show All 75 Publications.
Publications using 421-ML Applications Species
J Li, P Kong, C Chen, J Tang, X Jin, J Yan, Y Wang Targeting IL-17A Improves the Dysmotility of the Small Intestine and Alleviates the Injury of the Interstitial Cells of Cajal during Sepsis Oxid Med Cell Longev, 2019;2019(0):1475729. 2019 [PMID: 31531179] (In Vivo, Mouse) In Vivo Mouse
H Katsura, Y Kobayashi, PR Tata, BLM Hogan IL-1 and TNF? Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration Stem Cell Reports, 2019;0(0):. 2019 [PMID: 30930244] (Bioassay, Mouse) Bioassay Mouse
B Zwarycz, AD Gracz, KR Rivera, IA Williamson, LA Samsa, J Starmer, MA Daniele, L Salter-Cid, Q Zhao, ST Magness IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model Cell Mol Gastroenterol Hepatol, 2019;7(1):1-17. 2019 [PMID: 30364840] (Bioassay, Mouse) Bioassay Mouse
Y Okuyama, Y Tanaka, JJ Jiang, D Kamimura, A Nakamura, M Ota, T Ohki, D Higo, H Ogura, N Ishii, T Atsumi, M Murakami Bmi1 Regulates I?B? Degradation via Association with the SCF Complex J. Immunol., 2018;0(0):. 2018 [PMID: 30209188] (Bioassay, Mouse) Bioassay Mouse
Y Tanaka, L Sabharwal, M Ota, I Nakagawa, JJ Jiang, Y Arima, H Ogura, M Okochi, M Ishii, D Kamimura, M Murakami Presenilin 1 Regulates NF-?B Activation via Association with Breakpoint Cluster Region and Casein Kinase II J. Immunol., 2018;0(0):. 2018 [PMID: 30201812] (In Vivo, Mouse) In Vivo Mouse
M Bambouskov, L Gorvel, V Lampropoul, A Sergushich, E Loginichev, K Johnson, D Korenfeld, ME Mathyer, H Kim, LH Huang, D Duncan, H Bregman, A Keskin, A Santeford, RS Apte, R Sehgal, B Johnson, GK Amarasingh, MP Soares, T Satoh, S Akira, T Hai, C de Guzman, K Auclair, TP Roddy, SA Biller, M Jovanovic, E Klechevsky, KM Stewart, GJ Randolph, MN Artyomov Electrophilic properties of itaconate and derivatives regulate the�I?B?-ATF3 inflammatory axis Nature, 2018;556(7702):501-504. 2018 [PMID: 29670287] (Bioassay, Mouse) Bioassay Mouse
L Markey, L Shaban, ER Green, KP Lemon, J Mecsas, CA Kumamoto Pre-colonization with the commensal fungus Candida albicans reduces murine susceptibility to Clostridium difficile infection Gut Microbes, 2018;0(0):0. 2018 [PMID: 29667487] (In-Vivo, Mouse) In-Vivo Mouse
AS Chitre, MG Kattah, YY Rosli, M Pao, M Deswal, SG Deeks, PW Hunt, M Abdel-Mohs, LJ Montaner, CC Kim, A Ma, M Somsouk, JM McCune A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function PLoS Pathog., 2018;14(3):e1006806. 2018 [PMID: 29505600] (Bioassay, Mouse) Bioassay Mouse
C Navarrete, F Carrillo-S, B Palomares, M Mecha, C Jiménez-Ji, L Mestre, A Feliú, ML Bellido, BL Fiebich, G Appendino, MA Calzado, C Guaza, E Muñoz Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy J Neuroinflammation, 2018;15(1):64. 2018 [PMID: 29495967] (Bioassay, Mouse) Bioassay Mouse
A Mancini, M Tantucci, P Mazzocchet, A de Iure, V Durante, L Macchioni, C Giampà, A Alvino, L Gaetani, C Costa, A Tozzi, P Calabresi, M Di Filippo Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis Neurobiol. Dis., 2018;0(0):. 2018 [PMID: 29325869] (Bioassay, Mouse) Bioassay Mouse
Show All 75 Publications.

Reviews for IL-17/IL-17A (421-ML) (0)

There are no reviews for IL-17/IL-17A (421-ML). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

FAQs for IL-17/IL-17A (421-ML). (Showing 1 - 2 of 2 FAQs).

  1. I want to stain some T cell subsets (Th17 and Th1), do you have antibodies for that? I need for flow cytometer in sheep or goat.
    • Unfortunately, we have neither a CD4 antibody nor an IL-17 antibody that has been validated in sheep or goat, although if you would like to try one you would again be eligible for our Innovators Reward Program. Please contact us at with any questions regarding this program.
  2. I'm looking to establish an ELISA for IL-17 and want your recommendation on which antibody pairs to buy. Least expensive ones, please. Also, I'd like the detection antibody to be fluorescently labeled.
    • Thank you for your patience while I reviewed our ELISA validated products for IL17. I was not sure what species you were going to be investigating, so I looked up our data for the human protein. If this is incorrect, just let me know and I can look up products for the species you will be working with. As for antibody pairs, we only had one set that have been tested together: Capture: NBP2-22531 Detection: NBP2-22532. The detection product is only available currently with a biotin conjugate. We can however offer custom conjugation for this product to any of our available conjugates. Please see the following link to see the available fluors: The typical fee for custom conjugation is usually about $80 additional. Once you know which fluor you would like, I can provide you with a quote. We do also offer several ELISA kits for this target (they typically employ HRP or Biotin detection systems, so I am not sure if they will work for your needs).

Other Available Formats

Additional IL-17/IL-17A Products

Bioinformatics Tool for IL-17/IL-17A (421-ML)

Discover related pathways, diseases and genes to IL-17/IL-17A (421-ML). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for IL-17/IL-17A (421-ML)

Discover more about diseases related to IL-17/IL-17A (421-ML).

Pathways for IL-17/IL-17A (421-ML)

View related products by pathway.

PTMs for IL-17/IL-17A (421-ML)

Learn more about PTMs related to IL-17/IL-17A (421-ML).

Blogs on IL-17/IL-17A

There are no specific blogs for IL-17/IL-17A, but you can read our latest blog posts.
Recombinant Monoclonal Antibodies

Customers Who Bought This Also Bought

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our Recombinant Mouse IL-17A Protein and receive a gift card or discount.


Gene Symbol Il17a