Human IL-37/IL-1F7 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-37/IL-1F7 DuoSet ELISA, 15 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL37

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-37/IL-1F7 DuoSet ELISA, 15 Plate

• FIL1 zeta
• FIL1
• FIL1(ZETA)
• FIL1ZFIL1 zeta
• IL-1F7
• IL-1F7IL-1 zeta
• IL1H4IL1F7 (canonical product IL-1F7b)
• IL-1H4IL-1F7b (IL-1H4, IL-1H, IL-1RP1)
• IL-1RP1IL-1X protein
• IL1RP1interleukin 1 family member 7
• IL-1X
• IL37
• IL-37
• interleukin 1 family, member 7 (zeta)
• interleukin 1, zeta
• interleukin-1 family member 7
• Interleukin-1 homolog 4
• interleukin-1 superfamily z
• Interleukin-1 zeta
• Interleukin-1-related protein

Background

Human interleukin 37, also named IL-1F7, FIL1 zeta, IL-1H4, and IL-1rp1, belongs to the IL-1 cytokine family. With the exception of IL-18 that maps to human chromosome 11, all IL-1 family members map to the same cluster on human chromosome 2. Mouse IL-37 has not been reported, but human IL-37 is active on mouse cells. Five isoforms (IL-37a through e) are generated through alternative exon usage and have distinct expression profiles. Like IL-1 alpha, IL-1 beta and IL-18, all of the IL-37 variants lack a typical signal peptide.

Publications for IL-37/IL-1F7 (DY1975)(13)

Publications using DY1975

• D Kabelitz, M Zarobkiewi, M Heib, R Serrano, M Kunz, G Chitadze, D Adam, C Peters Signal strength of STING activation determines cytokine plasticity and cell death in human monocytes Scientific Reports, 2022-10-24;12(1):17827. 2022-10-24 [PMID: 36280676] (Human)
• N Ma, C Yuan, J Shi, Q Zhu, Y Liu, X Ma, B Li, W Gong, J Xue, G Lu, W Li, J Li Interleukin-37 protects against acinar cell pyroptosis in acute pancreatitis JCI Insight, 2022-11-08;0(0):. 2022-11-08 [PMID: 36166295] (Human)
• DG Osborne, J Domenico, M Fujita Expression of IL-37 Induces a Regulatory T-Cell-like Phenotype and Function in Jurkat Cells Cells, 2022-08-18;11(16):. 2022-08-18 [PMID: 36010641] (Human)
• F La Rosa, S Agostini, M Saresella, AS Costa, F Piancone, R Miglioli, F Trecate, M Clerici Deregulation of IL-37 and its miRNAs modulators in sarcopenic patients after rehabilitation Journal of Translational Medicine, 2021-04-26;19(1):172. 2021-04-26 [PMID: 33902634] (Human)
• V Paixão, EB Almeida, JB Amaral, T Roseira, FR Monteiro, R Foster, A Sperandio, M Rossi, GR Amirato, CAF Santos, RS Pires, FB Leal, EL Durigon, DBL Oliveira, RP Vieira, M Vaisberg, JMB Santos, ALL Bachi Elderly Subjects Supplemented with L-Glutamine Shows an Improvement of Mucosal Immunity in the Upper Airways in Response to Influenza Virus Vaccination Vaccines, 2021-01-31;9(2):. 2021-01-31 [PMID: 33572639] (Human)
• A Radujkovic, T Boch, F Nolte, D Nowak, C Kunz, A Gieffers, C Müller-Tid, P Dreger, WK Hofmann, T Luft Clinical Response to the CD95-Ligand Inhibitor Asunercept Is Defined by a Pro-Inflammatory Serum Cytokine Profile Cancers, 2020-12-08;12(12):. 2020-12-08 [PMID: 33302451] (Human)
• T Zhao, F Jin, D Xiao, H Wang, C Huang, X Wang, S Gao, J Liu, S Yang, J Hao IL-37/ STAT3/ HIF-1&alpha negative feedback signaling drives gemcitabine resistance in pancreatic cancer Theranostics, 2020-03-04;10(9):4088-4100. 2020-03-04 [PMID: 32226541] (Human)
• K Moideen, NP Kumar, R Bethunaick, VV Banurekha, D Nair, S Babu Heightened systemic levels of anti-inflammatory cytokines in pulmonary tuberculosis and alterations following anti-tuberculosis treatment Cytokine, 2019-12-04;127(0):154929. 2019-12-04 [PMID: 31811994] (Human)
• A Merz, U Germing, G Kobbe, J Kaivers, A Jauch, A Radujkovic, M Hummel, A Benner, M Merz, P Dreger, T Luft EASIX for prediction of survival in lower-risk myelodysplastic syndromes Blood Cancer J, 2019-11-11;9(11):85. 2019-11-11 [PMID: 31712595] (Human)
• Y Zhao, X Ni, P Xu, Q Liu, T Sun, X Liu, X Ji, J Qiu, J Li, S Wang, P Han, J Peng, M Hou, G Li Interleukin-37 reduces inflammation and impairs phagocytosis of platelets in immune thrombocytopenia (ITP) Cytokine, 2019-09-23;125(0):154853. 2019-09-23 [PMID: 31557634] (Human)
• ES Weiss, C Girard-Guy, D Holzinger, AA de Jesus, Z Tariq, J Picarsic, EJ Schiffrin, D Foell, AA Grom, S Ammann, S Ehl, T Hoshino, R Goldbach-M, C Gabay, SW Canna Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome Blood, 2018-01-11;0(0):. 2018-01-11 [PMID: 29326099] (Human)
• M Zhao, Y Hu, J Jin, Y Yu, S Zhang, J Cao, Y Zhai, R Wei, J Shou, W Cai, S Liu, X Yang, GT Xu, J Yang, DB Corry, SB Su, X Liu, T Yang Interleukin 37 promotes angiogenesis through TGF-? signaling Sci Rep, 2017-07-21;7(1):6113. 2017-07-21 [PMID: 28733640] (Human)
• Wang W, Zhao D, Zhou Y, Hu X, Sun Z, Yu G, Wu W, Chen S, Kuang J, Xu G, Han Z, Wang B, Yang J, Feng X Transfer of the IL-37b gene elicits anti-tumor responses in mice bearing 4T1 breast cancer. Acta Pharmacol Sin, 2015-04-01;36(4):528-34. 2015-04-01 [PMID: 25832432] (Mouse)

Bioinformatics

• Gene Symbol: IL37