Human IL-37/IL-1F7 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-37/IL-1F7 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL37

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-37/IL-1F7 DuoSet ELISA, 15 Plate

• FIL1 zeta
• FIL1
• FIL1(ZETA)
• FIL1ZFIL1 zeta
• IL-1F7
• IL-1F7IL-1 zeta
• IL1H4IL1F7 (canonical product IL-1F7b)
• IL-1H4IL-1F7b (IL-1H4, IL-1H, IL-1RP1)
• IL-1RP1IL-1X protein
• IL1RP1interleukin 1 family member 7
• IL-1X
• IL37
• IL-37
• interleukin 1 family, member 7 (zeta)
• interleukin 1, zeta
• interleukin-1 family member 7
• Interleukin-1 homolog 4
• interleukin-1 superfamily z
• Interleukin-1 zeta
• Interleukin-1-related protein

Background

Human interleukin 37, also named IL-1F7, FIL1 zeta, IL-1H4, and IL-1rp1, belongs to the IL-1 cytokine family. With the exception of IL-18 that maps to human chromosome 11, all IL-1 family members map to the same cluster on human chromosome 2. Mouse IL-37 has not been reported, but human IL-37 is active on mouse cells. Five isoforms (IL-37a through e) are generated through alternative exon usage and have distinct expression profiles. Like IL-1 alpha, IL-1 beta and IL-18, all of the IL-37 variants lack a typical signal peptide.

Publications for IL-37/IL-1F7 (DY1975)(14)

Publications using DY1975

• Beklen, A;Yavuz, MB;Uckan, D; Interleukin-37 reduces lipopolysaccharide induced matrix metalloproteinase-9 in gingival epithelial cells BMC oral health 2025-04-25 [PMID: 40281482] (Human)
• D Kabelitz, M Zarobkiewi, M Heib, R Serrano, M Kunz, G Chitadze, D Adam, C Peters Signal strength of STING activation determines cytokine plasticity and cell death in human monocytes Scientific Reports, 2022-10-24;12(1):17827. 2022-10-24 [PMID: 36280676] (Human)
• N Ma, C Yuan, J Shi, Q Zhu, Y Liu, X Ma, B Li, W Gong, J Xue, G Lu, W Li, J Li Interleukin-37 protects against acinar cell pyroptosis in acute pancreatitis JCI Insight, 2022-11-08;0(0):. 2022-11-08 [PMID: 36166295] (Human)
• DG Osborne, J Domenico, M Fujita Expression of IL-37 Induces a Regulatory T-Cell-like Phenotype and Function in Jurkat Cells Cells, 2022-08-18;11(16):. 2022-08-18 [PMID: 36010641] (Human)
• F La Rosa, S Agostini, M Saresella, AS Costa, F Piancone, R Miglioli, F Trecate, M Clerici Deregulation of IL-37 and its miRNAs modulators in sarcopenic patients after rehabilitation Journal of Translational Medicine, 2021-04-26;19(1):172. 2021-04-26 [PMID: 33902634] (Human)
• V Paixão, EB Almeida, JB Amaral, T Roseira, FR Monteiro, R Foster, A Sperandio, M Rossi, GR Amirato, CAF Santos, RS Pires, FB Leal, EL Durigon, DBL Oliveira, RP Vieira, M Vaisberg, JMB Santos, ALL Bachi Elderly Subjects Supplemented with L-Glutamine Shows an Improvement of Mucosal Immunity in the Upper Airways in Response to Influenza Virus Vaccination Vaccines, 2021-01-31;9(2):. 2021-01-31 [PMID: 33572639] (Human)
• A Radujkovic, T Boch, F Nolte, D Nowak, C Kunz, A Gieffers, C Müller-Tid, P Dreger, WK Hofmann, T Luft Clinical Response to the CD95-Ligand Inhibitor Asunercept Is Defined by a Pro-Inflammatory Serum Cytokine Profile Cancers, 2020-12-08;12(12):. 2020-12-08 [PMID: 33302451] (Human)
• T Zhao, F Jin, D Xiao, H Wang, C Huang, X Wang, S Gao, J Liu, S Yang, J Hao IL-37/ STAT3/ HIF-1&alpha negative feedback signaling drives gemcitabine resistance in pancreatic cancer Theranostics, 2020-03-04;10(9):4088-4100. 2020-03-04 [PMID: 32226541] (Human)
• K Moideen, NP Kumar, R Bethunaick, VV Banurekha, D Nair, S Babu Heightened systemic levels of anti-inflammatory cytokines in pulmonary tuberculosis and alterations following anti-tuberculosis treatment Cytokine, 2019-12-04;127(0):154929. 2019-12-04 [PMID: 31811994] (Human)
• A Merz, U Germing, G Kobbe, J Kaivers, A Jauch, A Radujkovic, M Hummel, A Benner, M Merz, P Dreger, T Luft EASIX for prediction of survival in lower-risk myelodysplastic syndromes Blood Cancer J, 2019-11-11;9(11):85. 2019-11-11 [PMID: 31712595] (Human)
• Y Zhao, X Ni, P Xu, Q Liu, T Sun, X Liu, X Ji, J Qiu, J Li, S Wang, P Han, J Peng, M Hou, G Li Interleukin-37 reduces inflammation and impairs phagocytosis of platelets in immune thrombocytopenia (ITP) Cytokine, 2019-09-23;125(0):154853. 2019-09-23 [PMID: 31557634] (Human)
• ES Weiss, C Girard-Guy, D Holzinger, AA de Jesus, Z Tariq, J Picarsic, EJ Schiffrin, D Foell, AA Grom, S Ammann, S Ehl, T Hoshino, R Goldbach-M, C Gabay, SW Canna Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome Blood, 2018-01-11;0(0):. 2018-01-11 [PMID: 29326099] (Human)
• M Zhao, Y Hu, J Jin, Y Yu, S Zhang, J Cao, Y Zhai, R Wei, J Shou, W Cai, S Liu, X Yang, GT Xu, J Yang, DB Corry, SB Su, X Liu, T Yang Interleukin 37 promotes angiogenesis through TGF-? signaling Sci Rep, 2017-07-21;7(1):6113. 2017-07-21 [PMID: 28733640] (Human)
• Wang W, Zhao D, Zhou Y, Hu X, Sun Z, Yu G, Wu W, Chen S, Kuang J, Xu G, Han Z, Wang B, Yang J, Feng X Transfer of the IL-37b gene elicits anti-tumor responses in mice bearing 4T1 breast cancer. Acta Pharmacol Sin, 2015-04-01;36(4):528-34. 2015-04-01 [PMID: 25832432] (Mouse)

FAQs for IL-37/IL-1F7 (DY1975). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: IL37