Recombinant Mouse ICAM-1/CD54 Fc Chimera Protein, CF

• Reactivity: Mu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Mouse ICAM-1/CD54 Fc Chimera Protein, CF Summary

• Details of Functionality: Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells. When 5 x 10 4 cells/well are added to rmICAM/Fc Chimera coated plates (12.5 µg/mL with 100 µL/well), approximately 65-95% will adhere after 1 hour incubation at 37 degreesC. Optimal dilutions should be determined by each laboratory for each application.
• Source: Mouse myeloma cell line, NS0-derived mouse ICAM-1/CD54 protein

  Mouse ICAM-1 (Gln28-Asn485) Accession # Q3U8M7

  IEGRMD

  Human IgG 1 (Pro100-Lys330)

  N-terminus

  C-terminus

• Accession #: Q3U8M7
• N-terminal Sequence: Gln28
• Structure / Form: Disulfide-linked homodimer
• Protein/Peptide Type: Recombinant Proteins
• Gene: Icam1
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 76.8 kDa (monomer).
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 110-130 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 3 months, -20 to -70 degreesC under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Reconstitution Instructions: Reconstitute at 0.4 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse ICAM-1/CD54 Fc Chimera Protein, CF

• BB2
• CD54 antigen
• CD54
• cell surface glycoprotein P3.58
• human rhinovirus receptor
• ICAM1
• ICAM-1
• intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
• intercellular adhesion molecule 1
• Major group rhinovirus receptor
• P3.58

Background

Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac-1. ICAM-1 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma , TNF-alpha , IL-1 beta and LPS. Mouse and human ICAM-1 share approximately 54% amino acid identity. Soluble ICAM-1 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, leukocyte adhesion deficiency syndrome (LAD), cancer and transplantation.

1. Pigott, R. and C. Power (1993) in The Adhesion Molecule Facts Book. Academic Press, p. 74.
2. Siu, G. et al. (1989) J. Immunol. 143:3813.
3. Ballantyne, C.M. et al. (1989) Nuc. Acid. Res. 17:5853.

Publications for ICAM-1/CD54 (796-IC)(86)

Publications using 796-IC

• Chen, Y;Hong, L;Wu, Q;Sun, M;Ling, M;Tong, H;Liu, Z; Chimonanthus salicifolius essential oil protects against endotoxin-induced acute lung injury via suppression of ?2 integrin-mediated neutrophil adhesion and chemotaxis Journal of ethnopharmacology 2025-08-13 [PMID: 40816582] (Bioassay, Mouse)
• Napoli, M;Immler, R;Rohwedder, I;Lupperger, V;Pfabe, J;Gonzalez Pisfil, M;Yevtushenko, A;Vogl, T;Roth, J;Salvermoser, M;Dietzel, S;Slak Rupnik, M;Marr, C;Walzog, B;Sperandio, M;Pruenster, M; Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment eLife 2024-12-19 [PMID: 39699020] (Bioassay, Mouse)
• Angiari, S;Carlucci, T;Budui, SL;Bach, SD;Dusi, S;Walter, J;Ellmeier, E;Schnabl, A;Stracke, A;Bordag, N;Tafrali, C;Demjaha, R;Khalil, M;Angelini, G;Terrabuio, E;Pietronigro, EC;Zenaro, E;Laudanna, C;Rossi, B;Constantin, G; Coenzyme A fueling with pantethine limits autoreactive T cell pathogenicity in experimental neuroinflammation Journal of neuroinflammation 2024-11-05 [PMID: 39501296] (Bioassay, Mouse)
• Maurice, D;Costello, P;Diring, J;Gualdrini, F;Frederico, B;Treisman, R; IL-2 delivery to CD8+ T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics Nature communications 2024-09-11 [PMID: 39261466] (Bioassay, Mouse)
• Juilland, M;Alouche, N;Ubezzi, I;Gonzalez, M;Rashid, HO;Scarpellino, L;Erdmann, T;Grau, M;Lenz, G;Luther, SA;Thome, M; Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination Proceedings of the National Academy of Sciences of the United States of America 2023-12-26 [PMID: 38109544] (Bioassay, Mouse)
• Pruenster, M;Immler, R;Roth, J;Kuchler, T;Bromberger, T;Napoli, M;Nussbaumer, K;Rohwedder, I;Wackerbarth, LM;Piantoni, C;Hennis, K;Fink, D;Kallabis, S;Schroll, T;Masgrau-Alsina, S;Budke, A;Liu, W;Vestweber, D;Wahl-Schott, C;Roth, J;Meissner, F;Moser, M;Vogl, T;Hornung, V;Broz, P;Sperandio, M; E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation Nature immunology 2023-10-30 [PMID: 37903858] (Bioassay, Mouse, Transgenic Mouse)
• CP Camargo, AK Muhuri, Y Alapan, LF Sestito, M Khosla, MP Manspeaker, AS Smith, CM Paulos, SN Thomas A dhesion analysis via a tumor vasculature-like microfluidic device identifies CD8+ T�cells with enhanced tumor homing to improve cell therapy Cell Reports, 2023-02-26;42(3):112175. 2023-02-26 [PMID: 36848287] (Bioassay, Mouse)
• J Li, Z Yao, X Liu, R Duan, X Yi, A Ayoub, JO Sanders, A Mesfin, L Xing, BF Boyce TGFbeta1+CCR5+ neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice Nature Communications, 2023-01-11;14(1):159. 2023-01-11 [PMID: 36631487] (Bioassay, Mouse)
• S Kohara, K Ogawa Eph/Ephrin Promotes the Adhesion of Liver Tissue-Resident Macrophages to a Mimicked Surface of Liver Sinusoidal Endothelial Cells Biomedicines, 2022-12-12;10(12):. 2022-12-12 [PMID: 36551990] (Bioassay, Mouse)
• S Silva Pere, M De Niz, K Serre, M Ouarné, JE Coelho, CA Franco, LM Figueiredo Immunopathology and Trypanosoma congolense parasite sequestration cause acute cerebral trypanosomiasis Elife, 2022-07-05;11(0):. 2022-07-05 [PMID: 35787830] (Bioassay, Mouse)
• L Wen, A Marki, Z Wang, M Orecchioni, J Makings, M Billitti, E Wang, SSA Suthahar, K Kim, WB Kiosses, Z Mikulski, K Ley A humanized beta2 integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in�vivo Cell Reports, 2022-05-31;39(9):110876. 2022-05-31 [PMID: 35649374] (Bioassay, Mouse)
• T Bromberger, S Klapproth, M Sperandio, M Moser Humanized beta2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation Cells, 2022-05-03;11(9):. 2022-05-03 [PMID: 35563841] (Bioassay, Mouse)
• Z Ou, E Dolmatova, R Mandavilli, H Qu, G Gafford, T White, A Valdivia, B Lassègue, MS Hernandes, KK Griendling Myeloid Poldip2 Contributes to the Development of Pulmonary Inflammation by Regulating Neutrophil Adhesion in a Murine Model of Acute Respiratory Distress Syndrome Journal of the American Heart Association, 2022-05-10;11(10):e025181. 2022-05-10 [PMID: 35535614] (Bioassay, Mouse)
• Z Jing, MJ McCarron, ML Dustin, DR Fooksman Germinal center expansion but not plasmablast differentiation is proportional to peptide-MHCII density via CD40-CD40L signaling strength Cell Reports, 2022-05-03;39(5):110763. 2022-05-03 [PMID: 35508132] (Bioassay, Mouse)
• Z Benet, Z Jing, DR Fooksman Plasma cell dynamics in the bone marrow niche Cell Reports, 2021-02-09;34(6):108733. 2021-02-09 [PMID: 33567286] (Bioassay, Mouse)
• NH Roy, SHJ Kim, A Buffone, D Blumenthal, B Huang, S Agarwal, PL Schwartzbe, DA Hammer, JK Burkhardt LFA-1 signals to promote actin polymerization and upstream migration in T cells J. Cell. Sci., 2020-09-09;133(17):. 2020-09-09 [PMID: 32907931] (Bioassay, Mouse)
• A Reversat, F Gaertner, J Merrin, J Stopp, S Tasciyan, J Aguilera, I de Vries, R Hauschild, M Hons, M Piel, A Callan-Jon, R Voituriez, M Sixt Cellular locomotion using environmental topography Nature, 2020-05-13;582(7813):582-585. 2020-05-13 [PMID: 32581372] (Cell Culture, Mouse)
• V Azcutia, M Kelm, AC Luissint, K Boerner, S Flemming, M Quiros, G Newton, A Nusrat, FW Luscinskas, CA Parkos Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo Mucosal Immunol, 2020-06-19;0(0):. 2020-06-19 [PMID: 32561828] (Bioassay, Mouse)
• NH Roy, M Mammadli, JK Burkhardt, M Karimi CrkL is required for donor T cell migration to GvHD target organs Oncotarget, 2020-04-28;11(17):1505-1514. 2020-04-28 [PMID: 32391120] (Bioassay, Mouse)
• V Barbier, J Erbani, C Fiveash, JM Davies, J Tay, MR Tallack, J Lowe, JL Magnani, DR Pattabiram, AC Perkins, J Lisle, JEJ Rasko, JP Levesque, IG Winkler Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance Nat Commun, 2020-04-27;11(1):2042. 2020-04-27 [PMID: 32341362] (Bioassay, Mouse)
• GR Meehan, HE Scales, R Osii, M De Niz, JC Lawton, M Marti, P Garside, A Craig, JM Brewer Developing a xenograft model of human vasculature in the mouse ear pinna Sci Rep, 2020-02-06;10(1):2058. 2020-02-06 [PMID: 32029768] (Bioassay, Mouse)
• A Salz, C Gurniak, F Jönsson, W Witke Cofilin1 driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus J. Cell. Sci., 2020-03-06;0(0):. 2020-03-06 [PMID: 31974112] (Bioassay, Mouse)
• C Ren, Q Yuan, X Jian, PA Randazzo, W Tang, D Wu Small GTPase ARF6 Is a Coincidence-Detection Code for RPH3A Polarization in Neutrophil Polarization J. Immunol., 2020-01-10;0(0):. 2020-01-10 [PMID: 31924649] (Bioassay, Mouse)
• GS Gülcüler B, C Monzel, S Kleber, J Beaudouin, E Balta, T Kaindl, S Chen, L Gao, M Thiemann, CR Wirtz, Y Samstag, M Tanaka, A Martin-Vil 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival Cell Rep, 2019-11-19;29(8):2295-2306.e6. 2019-11-19 [PMID: 31747602] (Binding Assay, Mouse)
• D Engelberts, A Autio, RAF Verwillige, MAC Depuydt, G Newton, S Rattik, E Levinsohn, G Saggu, P Jarolim, H Wang, F Velazquez, AH Lichtman, FW Luscinskas Increased lymphocyte activation and atherosclerosis in CD47-deficient mice Sci Rep, 2019-07-23;9(1):10608. 2019-07-23 [PMID: 31337788] (Cell Culture, Mouse)
• MC Schmid, SQ Khan, MM Kaneda, P Pathria, R Shepard, TL Louis, S Anand, G Woo, C Leem, MH Faridi, T Geraghty, A Rajagopala, S Gupta, M Ahmed, RI Vazquez-Pa, DA Cheresh, V Gupta, JA Varner Integrin CD11b activation drives anti-tumor innate immunity Nat Commun, 2018-12-19;9(1):5379. 2018-12-19 [PMID: 30568188] (Bioassay, Mouse)
• J Chen, N Li, Y Yin, N Zheng, M Min, B Lin, L Zhang, X Long, Y Zhang, Z Cai, S Zhai, J Qin, X Wang Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells Cell Rep, 2018-12-18;25(12):3393-3404.e6. 2018-12-18 [PMID: 30566865] (Bioassay, Mouse)
• RJ Kimmerling, SM Prakadan, AJ Gupta, NL Calistri, MM Stevens, S Olcum, N Cermak, RS Drake, K Pelton, F De Smet, KL Ligon, AK Shalek, SR Manalis Linking single-cell measurements of mass, growth rate, and gene expression Genome Biol., 2018-11-27;19(1):207. 2018-11-27 [PMID: 30482222] (Bioassay, Mouse)
• FA Moretti, S Klapproth, R Ruppert, A Margraf, J Weber, R Pick, C Scheierman, M Sperandio, R Fässler, M Moser Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus Elife, 2018-09-06;7(0):. 2018-09-06 [PMID: 30187863] (Bioassay, Mouse)
• M Keszei, J Record, JS Kritikou, H Wurzer, C Geyer, M Thiemann, P Drescher, H Brauner, L Köcher, J James, M He, MA Baptista, CI Dahlberg, A Biswas, S Lain, DP Lane, W Song, K Pütsep, P Vandenberg, SB Snapper, LS Westerberg Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive J. Clin. Invest., 2018-08-20;128(9):4115-4131. 2018-08-20 [PMID: 30124469] (Bioassay, Mouse)
• A Farinazzo, S Angiari, E Turano, E Bistaffa, S Dusi, S Ruggieri, R Bonafede, R Mariotti, G Constantin, B Bonetti Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis Sci Rep, 2018-05-10;8(1):7473. 2018-05-10 [PMID: 29748664] (Bioassay, Mouse)
• M Praetner, G Zuchtriege, M Holzer, B Uhl, J Schaubäche, L Mittmann, M Fabritius, R Fürst, S Zahler, D Funken, M Lerchenber, A Khandoga, S Kanse, K Lauber, F Krombach, CA Reichel Plasminogen Activator Inhibitor-1 Promotes Neutrophil Infiltration and Tissue Injury on Ischemia-Reperfusion Arterioscler. Thromb. Vasc. Biol., 2018-01-25;0(0):. 2018-01-25 [PMID: 29371242] (Flow Cytometry, Mouse)
• S Paetau, T Rolova, L Ning, CG Gahmberg Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia Front Mol Neurosci, 2017-12-22;10(0):431. 2017-12-22 [PMID: 29311819] (Bioassay, Mouse)
• S Adutler-Li, I Zaretsky, H Sabany, E Kartvelish, O Golani, B Geiger, N Friedman Substrate-bound CCL21 and ICAM1 combined with soluble IL-6 collectively augment the expansion of antigen-specific murine CD4+ T cells Blood Adv, 2017-06-15;1(15):1016-1030. 2017-06-15 [PMID: 29296744] (Bioassay, Mouse)
• L Ju, Y Chen, K Li, Z Yuan, B Liu, SP Jackson, C Zhu Dual Biomembrane Force Probe enables single-cell mechanical analysis of signal crosstalk between multiple molecular species Sci Rep, 2017-10-27;7(1):14185. 2017-10-27 [PMID: 29079742] (Bioassay, Mouse)
• CP Basole, RK Nguyen, K Lamothe, A Vang, R Clark, GS Baillie, PM Epstein, S Brocke PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex Cell. Signal., 2017-08-26;40(0):62-72. 2017-08-26 [PMID: 28851628] (Bioassay, Mouse)
• JG Borger, VL Morrison, A Filby, C Garcia, LM Uotila, F Simbari, SC Fagerholm, R Zamoyska Caveolin-1 Influences LFA-1 Redistribution upon TCR Stimulation in CD8 T Cells J. Immunol., 2017-06-21;0(0):. 2017-06-21 [PMID: 28637901] (Bioassay, Mouse)
• BR Gittens, JV Bodkin, S Nourshargh, M Perretti, D Cooper Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation J. Immunol., 2017-04-24;0(0):. 2017-04-24 [PMID: 28438899] (Bioassay, Mouse)
• Y Hirano, WL Yang, M Aziz, F Zhang, B Sherry, P Wang MFG-E8-derived peptide attenuates adhesion and migration of immune cells to endothelial cells J. Leukoc. Biol, 2017-01-17;0(0):. 2017-01-17 [PMID: 28096298] (Bioassay, Mouse)
• Sophia Koutsogian Prolonged exposure to volatile anesthetic isoflurane worsens the outcome of polymicrobial abdominal sepsis Toxicol. Sci, 2017-04-01;0(0):. 2017-04-01 [PMID: 28003439] (Bioassay, Mouse)
• Janice Chou Glycogen storage disease type Ib neutrophils exhibit impaired cell adhesion and migration Biochem. Biophys. Res. Commun., 2016-11-15;0(0):. 2016-11-15 [PMID: 27864142] (Bioassay, Mouse)
• Aged neutrophils contribute to the first line of defense in the acute inflammatory response Blood, 2016-09-08;0(0):. 2016-09-08 [PMID: 27609642] (Flow Cytometry, Mouse)
• ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens J Leukoc Biol, 2016-09-07;0(0):. 2016-09-07 [PMID: 27605210] (Bioassay, Mouse)
• Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice J Immunol, 2016-08-26;0(0):. 2016-08-26 [PMID: 27566826] (Bioassay, Mouse)
• Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration J Immunol, 2016-07-27;0(0):. 2016-07-27 [PMID: 27465533] (Bioassay, Mouse)
• Pyk2 Controls Integrin-Dependent CTL Migration through Regulation of De-Adhesion J Immunol, 2016-07-25;0(0):. 2016-07-25 [PMID: 27456486] (Bioassay, Mouse)
• WNK1 kinase balances T cell adhesion versus migration in vivo Nat Immunol, 2016-07-11;0(0):. 2016-07-11 [PMID: 27400149] (Bioassay, Human)
• Henriette Rudolph Post-arrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro Eur J Immunol, 2016-07-22;0(0):. 2016-07-22 [PMID: 27338806] (Bioassay, Mouse)
• Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice Eur J Immunol, 2016-06-08;0(0):. 2016-06-08 [PMID: 27188212] (Bioassay, Mouse)
• Platelets Guide Leukocytes to Their Sites of Extravasation PLoS Biol, 2016-05-06;14(5):e1002459. 2016-05-06 [PMID: 27152726] (Bioassay, Mouse)
• Martin-Blondel G, Pignolet B, Tietz S, Yshii L, Gebauer C, Perinat T, Van Weddingen I, Blatti C, Engelhardt B, Liblau R Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the alpha4beta1-integrin. Eur J Immunol, 2015-10-06;45(12):3302-12. 2015-10-06 [PMID: 26358409] (Bioassay, Mouse)
• Yago T, Tsukamoto H, Liu Z, Wang Y, Thompson L, McEver R Multi-Inhibitory Effects of A2A Adenosine Receptor Signaling on Neutrophil Adhesion Under Flow. J Immunol, 2015-09-09;195(8):3880-9. 2015-09-09 [PMID: 26355151] (Bioassay, Mouse)
• Yago T, Petrich B, Zhang N, Liu Z, Shao B, Ginsberg M, McEver R Blocking neutrophil integrin activation prevents ischemia-reperfusion injury. J Exp Med, 2015-07-13;212(8):1267-81. 2015-07-13 [PMID: 26169939] (Bioassay, Mouse)
• Na B, Kim H, Piragyte I, Oh H, Kwon M, Akber U, Lee H, Park D, Song W, Park Z, Im S, Rho M, Hyun Y, Kim M, Jun C TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse. J Cell Biol, 2015-04-13;209(1):143-62. 2015-04-13 [PMID: 25869671] (Adhesion Assay, Mouse)
• Huang , Yanping, Clarke , Fiona, Karimi , Mobin, Roy , Nathan H, Williamson , Edward K, Okumura , Mariko, Mochizuki , Kazuhiro, Chen , Emily J, Park , Tae-Ju, Debes , Gudrun F, Zhang , Yi, Curran , Tom, Kambayashi , Taku, Burkhardt , Janis K CRK proteins selectively regulate T cell migration into inflamed tissues. J Clin Invest, 2015-01-26;125(3):1019-32. 2015-01-26 [PMID: 25621495] (Bioassay, Mouse)
• Germena G, Volmering S, Sohlbach C, Zarbock A Mutation in the CD45 inhibitory wedge modulates integrin activation and leukocyte recruitment during inflammation. J Immunol, 2014-12-10;194(2):728-38. 2014-12-10 [PMID: 25505282] (Bioassay, Mouse)
• Kovacs M, Nemeth T, Jakus Z, Sitaru C, Simon E, Futosi K, Botz B, Helyes Z, Lowell C, Mocsai A The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. J Exp Med, 2014-09-15;211(10):1993-2011. 2014-09-15 [PMID: 25225462] (Bioassay, Mouse)
• Camirand , Geoffrey, Wang , Ying, Lu , Yuning, Wan , Yisong Y, Lin , Yan, Deng , Songyan, Guz , Galip, Perkins , David L, Finn , Patricia, Farber , Donna L, Flavell , Richard, Shlomchik , Warren D, Lakkis , Fadi G, Rudd , Christop, Rothstein , David M CD45 ligation expands Tregs by promoting interactions with DCs. J Clin Invest, 2014-09-09;124(10):4603-13. 2014-09-09 [PMID: 25202978] (Bioassay, Mouse)
• Morrison A, Yarovinsky T, Young B, Moraes F, Ross T, Ceneri N, Zhang J, Zhuang Z, Sinusas A, Pardi R, Schwartz M, Simons M, Bender J Chemokine-coupled beta2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exp Med, 2014-09-01;211(10):1957-68. 2014-09-01 [PMID: 25180062] (Bioassay, Mouse)
• Xu , Xiaolu, Jaeger , Emily R, Wang , Xinxin, Lagler-Ferrez , Erica, Batalov , Serge, Mathis , Nancy L, Wiltshire , Tim, Walker , John R, Cooke , Michael, Sauer , Karsten, Huang , Yina H Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration. PLoS ONE, 2014-08-18;9(8):e105561. 2014-08-18 [PMID: 25133611] (Bioassay, Mouse)
• Palmi C, Fazio G, Savino A, Procter J, Howell L, Cazzaniga V, Vieri M, Longinotti G, Brunati I, Andre V, Della Mina P, Villa A, Greaves M, Biondi A, D'Amico G, Ford A, Cazzaniga G Cytoskeletal regulatory gene expression and migratory properties of B-cell progenitors are affected by the ETV6-RUNX1 rearrangement. Mol Cancer Res, 2014-07-24;12(12):1796-806. 2014-07-24 [PMID: 25061103] (Bioassay, Mouse)
• Knowlden S, Capece T, Popovic M, Chapman T, Rezaee F, Kim M, Georas S Regulation of T cell motility in vitro and in vivo by LPA and LPA2. PLoS ONE, 2014-07-08;9(7):e101655. 2014-07-08 [PMID: 25003200] (Bioassay, Mouse)
• Gobel K, Schuhmann M, Pankratz S, Stegner D, Herrmann A, Braun A, Breuer J, Bittner S, Ruck T, Wiendl H, Kleinschnitz C, Nieswandt B, Meuth S Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis. Eur J Immunol, 2014-06-05;44(8):2295-305. 2014-06-05 [PMID: 24811005] (Bioassay, Mouse)
• Wang X, Rodda L, Bannard O, Cyster J Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness. J Immunol, 2014-04-16;192(10):4601-9. 2014-04-16 [PMID: 24740506] (Bioassay, Mouse)
• Jung H, Song K, Chang J, Doh J Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays. PLoS ONE, 2014-03-14;9(3):e91926. 2014-03-14 [PMID: 24632942] (Bioassay)
• Jenkins , Misty R, Stinchcombe , Jane C, Au-Yeung , Byron B, Asano , Yukako, Ritter , Alex T, Weiss , Arthur, Griffiths , Gillian Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL. Elife, 2014-03-04;3(0):e01310. 2014-03-04 [PMID: 24596147] (Bioassay, Mouse)
• Korthals M, Schilling K, Reichardt P, Mamula D, Schluter T, Steiner M, Langnase K, Thomas U, Gundelfinger E, Premont R, Tedford K, Fischer K alphaPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes. J Immunol, 2014-03-03;192(7):3228-38. 2014-03-03 [PMID: 24591366] (Bioassay, Mouse)
• Foley M, Forcier T, McAndrew E, Gonzalez M, Chen H, Juelg B, Walker B, Irvine D High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function. PLoS ONE, 2014-02-13;9(2):e87873. 2014-02-13 [PMID: 24551068] (Bioassay, Human)
• Bosticardo , Marita, Musio , Silvia, Fontana , Elena, Angiari , Stefano, Draghici , Elena, Constantin , Gabriela, Poliani , Pietro L, Pedotti , Rosetta, Villa , Anna Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein. PLoS ONE, 2014-01-23;9(1):e86942. 2014-01-23 [PMID: 24466296] (Bioassay, Mouse)
• Weckbach L, Gola A, Winkelmann M, Jakob S, Groesser L, Borgolte J, Pogoda F, Pick R, Pruenster M, Muller-Hocker J, Deindl E, Sperandio M, Walzog B The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via beta2 integrins (CD11/CD18). Blood, 2014-01-23;123(12):1887-96. 2014-01-23 [PMID: 24458438] (Bioassay, Mouse)
• Dalli , Jesmond, Norling , Lucy V, Montero-Melendez , Trinidad, Federici Canova , Donata, Lashin , Hazem, Pavlov , Anton M, Sukhorukov , Gleb B, Hinds , Charles, Perretti , Mauro Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med, 2013-12-15;6(1):27-42. 2013-12-15 [PMID: 24357647] (Bioassay, Mouse)
• Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T A circadian clock gene, Rev-erbalpha, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression. J Immunol, 2013-12-04;192(1):407-17. 2013-12-04 [PMID: 24307731] (Bioassay, Mouse)
• Dong B, Zhang S, Gao W, Su H, Chen J, Jin F, Bhargava A, Chen X, Jorgensen L, Alberts A, Zhang J, Siminovitch K Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization. PLoS ONE, 2013-11-18;8(11):e80500. 2013-11-18 [PMID: 24260404] (Bioassay, Mouse)
• Cannon J, Asperti-Boursin F, Letendre K, Brown I, Korzekwa K, Blaine K, Oruganti S, Sperling A, Moses M PKCtheta regulates T cell motility via ezrin-radixin-moesin localization to the uropod. PLoS ONE, 2013-11-08;8(11):e78940. 2013-11-08 [PMID: 24250818] (Bioassay, Mouse)
• Schmitt , Martin M, Megens , Remco T, Zernecke , Alma, Bidzhekov , Kiril, van den Akker , Nynke M, Rademakers , Timo, van Zandvoort , Marc A, Hackeng , Tilman M, Koenen , Rory R, Weber , Christia Endothelial junctional adhesion molecule-a guides monocytes into flow-dependent predilection sites of atherosclerosis. Circulation, 2013-09-24;129(1):66-76. 2013-09-24 [PMID: 24065611] (Bioassay, Mouse)
• Perez-Rivero G, Cascio G, Soriano S, Sanz A, de Guinoa J, Rodriguez-Frade J, Gomariz R, Holgado B, Cabanas C, Carrasco Y, Stein J, Mellado M Janus kinases 1 and 2 regulate chemokine-mediated integrin activation and naive T-cell homing. Eur J Immunol, 2013-05-17;43(7):1745-57. 2013-05-17 [PMID: 23526587] (Bioassay, Mouse)
• Giegold O, Ogrissek N, Richter C, Schroder M, Herrero San Juan M, Pfeilschifter J, Radeke H CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation. J Immunol, 2013-02-27;190(7):3696-705. 2013-02-27 [PMID: 23447686] (Bioassay, Mouse)
• Marangoni F, Murooka T, Manzo T, Kim E, Carrizosa E, Elpek N, Mempel T The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells. Immunity, 2013-01-11;38(2):237-49. 2013-01-11 [PMID: 23313588] (Bioassay, Mouse)
• Furutani Y, Kawasaki M, Matsuno H, Mitsui S, Mori K, Yoshihara Y Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin. J Biol Chem, 2012-09-27;287(46):39041-9. 2012-09-27 [PMID: 23019340] (Surface Plasmon Resonance)
• Hyun YM, Sumagin R, Sarangi PP Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J. Exp. Med., 2012-06-18;209(7):1349-62. 2012-06-18 [PMID: 22711877] (Bioassay, Mouse)
• Verma N, Dempsey E, Long A, Davies A, Barry S, Fallon P, Volkov Y, Kelleher D Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-beta signaling. J Biol Chem, 2012-06-15;287(32):27204-16. 2012-06-15 [PMID: 22707713] (Bioassay, Mouse)
• Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH Difference in Th1 and Th17 lymphocyte adhesion to endothelium. J. Immunol., 2012-01-04;188(3):1421-30. 2012-01-04 [PMID: 22219321] (Bioassay, Mouse)
• Markiewicz MA, Wise EL, Buchwald ZS, Cheney EE, Hansen TH, Suri A, Cemerski S, Allen PM, Shaw AS IL-12 enhances CTL synapse formation and induces self-reactivity. J. Immunol., 2009-02-01;182(3):1351-61. 2009-02-01 [PMID: 19155481] (Bioassay, Mouse)
• Park EJ, Mora JR, Carman CV, Chen J, Sasaki Y, Cheng G, von Andrian UH, Shimaoka M Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. J. Clin. Invest., 2007-09-01;117(9):2526-38. 2007-09-01 [PMID: 17786243] (Bioassay, Mouse)
• Kelly KA, Allport JR, Yu AM, Sinh S, Sage EH, Gerszten RE, Weissleder R SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration. J. Leukoc. Biol., 2006-12-18;81(3):748-56. 2006-12-18 [PMID: 17178915] (Bioassay, Human, Mouse)
• Bate C, Kempster S, Williams A Prostaglandin D2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells. Neuropharmacology, 2005-11-11;50(2):229-37. 2005-11-11 [PMID: 16289250] (Control, Mouse)

Bioinformatics

• Gene Symbol: Icam1
• Uniprot:
  • Q3U8M7()