Recombinant Mouse Follistatin 288 (FS-288) Protein


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Product Details

Reactivity MuSpecies Glossary
Applications Bioactivity

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Recombinant Mouse Follistatin 288 (FS-288) Protein Summary

Details of Functionality
Measured by its ability to neutralize Activin-mediated erythroid differentiation of K562 human chronic myelogenous leukemia cells. The ED50 for this effect is 0.1‑0.4 µg/mL in the presence of 7.5 ng/mL rhActivin A.
Spodoptera frugiperda, Sf 21 (baculovirus)-derived mouse Follistatin protein
Gly30-Asn317, with an N-terminal Met
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.


Theoretical MW
31 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
35-40 kDa, reducing conditions
Read Publications using
769-FS in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 10 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse Follistatin 288 (FS-288) Protein

  • follistatin isoform FST317
  • Follistatin
  • FS
  • FSActivin-binding protein
  • FST


Follistatin (FS) was initially identified as a follicle-stimulating hormone inhibiting substance found in ovarian follicular fluid. It has since been shown that FS is a high-affinity activin-binding protein that can act as an activin antagonist. Two alternatively spliced follistatin mRNAs, encoding mature FS with 288 amino acid (aa) residues (FS-288) and 315 aa residues (FS-315), exist. Natural FS purified from porcine ovaries is primarily a carboxy-terminal truncated form of FS-315 composed of 300 aa residues. FS-288 binds with high-affinity to cell-surface heparan sulfate proteoglycans whereas FS-315 binds with low-affinity. Cell surface-associated FS has been suggested to play a role in the clearance and bioavailability of activin in vivo. Besides activin, FS has also been shown to bind with multiple BMPs and to inhibit BMP activity in early Xenopus embryos. FS deficient mice have been shown to have multiple embryonic defects that will result in death shortly after birth. Overexpression of FS can also cause reproductive defects in transgenic mice.

  1. Iemura, S. et al. (1998) Proc. Natl. Acad. Sci. USA 95:9337.
  2. Guo, Q. (1998) Mol. Endocrinol. 12:96.
  3. Hashimoto, O. et al. (1997) J. Biol. Chem. 272:13835.

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Publications for Follistatin (769-FS)(7)

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 3 applications: Bioassay, Expansion/Differentiation, In Vivo.

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Showing Publications 1 - 7 of 7.
Publications using 769-FS Applications Species
Wang Z, Niu W, Wang Y, Teng Z, Wen J, Xia G, Wang C Follistatin288 Regulates Germ Cell Cyst Breakdown and Primordial Follicle Assembly in the Mouse Ovary. PLoS ONE, 2015;10(6):e0129643. 2015 [PMID: 26076381] (Bioassay, Mouse) Bioassay Mouse
Chen C, Murray P, Jiang T, Plikus M, Chang Y, Lee O, Widelitz R, Chuong C Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4. J Invest Dermatol, 2014;134(8):2086-96. 2014 [PMID: 24618599] (In Vivo, Mouse) In Vivo Mouse
Silla Z, Naidoo J, Kidson S, Sommer P Signals from the lens and Foxc1 regulate the expression of key genes during the onset of corneal endothelial development. Exp Cell Res, 2014;322(2):381-8. 2014 [PMID: 24472616] (Bioassay, Mouse) Bioassay Mouse
Braga M, Reddy S, Vergnes L, Pervin S, Grijalva V, Stout D, David J, Li X, Tomasian V, Reid C, Norris K, Devaskar S, Reue K, Singh R Follistatin promotes adipocyte differentiation, browning, and energy metabolism. J Lipid Res, 2014;55(3):375-84. 2014 [PMID: 24443561] (Bioassay, Mouse) Bioassay Mouse
Roelandt P, Pauwelyn KA, Sancho-Bru P Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE, 2010;5(8):e12101. 2010 [PMID: 20711405] (Expansion/Differentiation, Rat) Expansion/Differentiation Rat
Sun Y, Ge Y, Drnevich J, Zhao Y, Band M, Chen J Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis. J. Cell Biol., 2010;189(7):1157-69. 2010 [PMID: 20566686] (Bioassay, Mouse) Bioassay Mouse
Lindsley RC, Gill JG, Kyba M, Murphy TL, Murphy KM Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development, 2006;133(19):3787-96. 2006 [PMID: 16943279] (Bioassay, Mouse) Bioassay Mouse

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Gene Symbol Fst