Recombinant Human VCAM-1/CD106 Fc Chimera Protein, CF


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Product Details

Reactivity HuSpecies Glossary
Applications Bioactivity

Order Details

Recombinant Human VCAM-1/CD106 Fc Chimera Protein, CF Summary

Details of Functionality
Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When 5 x 104 cells/well are added to human VCAM-1 coated plates (10 µg/mL with 100 µL/well), approximately 90-100% will adhere after 1 hour incubation at RT.
Optimal dilutions should be determined by each laboratory for each application.
Mouse myeloma cell line, NS0-derived human VCAM-1/CD106 protein
Met Human VCAM-1
Accession # P19320
6-His tag
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
101.6 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
115-130 kDa, reducing conditions
Read Publications using
862-VC in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human VCAM-1/CD106 Fc Chimera Protein, CF

  • CD106 antigen
  • CD106
  • DKFZp779G2333
  • INCAM-100
  • L1CAM
  • MGC99561
  • vascular cell adhesion molecule 1
  • vascular cell adhesion protein 1
  • V-CAM 1
  • VCAM1
  • VCAM-1


Human VCAM-1 (CD106, INCAM-110) is a cell adhesion molecule and a member of the immunoglobulin superfamily. Alternatively spliced forms are known to occur, but the most common form is a type I transmembrane protein with a 674 amino acid extracellular segment that includes seven C2-type immunoglobulin domains. VCAM-1 is expressed by activated endothelial cells and certain other cell types including macrophages, dendritic cells, neurons, smooth muscle cells, fibroblasts, and oocytes. VCAM-1 binds to leukocyte integrins alpha 4 beta 1 (VLA-4) and alpha 4 beta 7. During the inflammatory adhesion mechanism, activated integrins halt rolling leukocytes and attach them firmly to the vascular endothelium. They do this by binding to their ligands, for example VCAM-1, on endothelium. The VCAM-1:VLA-4/ alpha 4 beta 7 interaction is also thought to be involved in the extravasation of white blood cells through the blood vessel wall to sites of inflammation. ELISA techniques have shown that detectable levels of soluble VCAM-1 are present in the biological fluids of apparently normal individuals. Furthermore, a number of studies have reported that levels of VCAM-1 may be elevated or lowered in subjects with a variety of pathological conditions.

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Publications for VCAM-1/CD106 (862-VC)(17)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Adhesion Assay, Bioassay, Cell Culture.

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Adhesion Assay
Cell Culture
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Showing Publications 1 - 10 of 17. Show All 17 Publications.
Publications using 862-VC Applications Species
A Natoni, ML Farrell, S Harris, C Falank, L Kirkham-Mc, MS Macauley, MR Reagan, M O' Dwyer Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model Haematologica, 2019;0(0):. 2019 [PMID: 31101754] (Bioassay, Human) Bioassay Human
D Karpova, MP Rettig, J Ritchey, D Cancilla, S Christ, L Gehrs, E Chendamara, MO Evbuomwan, M Holt, J Zhang, G Abou-Ezzi, H Celik, E Wiercinska, W Yang, F Gao, LG Eissenberg, RF Heier, SD Arnett, MJ Meyers, MJ Prinsen, DW Griggs, A Trumpp, PG Ruminski, DM Morrow, HB Bonig, DC Link, JF DiPersio Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells J. Clin. Invest., 2019;129(7):2745-2759. 2019 [PMID: 31085833] (Cell Culture, Human) Cell Culture Human
JM Laufer, R Lyck, DF Legler ZAP70 expression enhances chemokine-driven chronic lymphocytic leukemia cell migration and arrest by valency regulation of integrins FASEB J., 2018;0(0):fj201701452RR. 2018 [PMID: 29589978] (Bioassay, Human) Bioassay Human
G Petkau, Y Kawano, I Wolf, M Knoll, F Melchers MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice Eur. J. Immunol., 2018;0(0):. 2018 [PMID: 29505092] (Bioassay, Mouse) Bioassay Mouse
PJ Stewart-Hu, TP Szasz, ER Jaeger, MD Onken, JA Cooper, SC Morley Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate J. Leukoc. Biol., 2017;0(0):. 2017 [PMID: 28637896] (Bioassay, Mouse) Bioassay Mouse
M Moslem, R Eggenschwi, C Wichmann, R Buhmann, T Cantz, R Henschler Kindlin-2 Modulates the Survival, Differentiation, and Migration of Induced Pluripotent Cell-Derived Mesenchymal Stromal Cells Stem Cells Int, 2017;2017(0):7316354. 2017 [PMID: 28163724] (Bioassay, Human) Bioassay Human
Sophia Koutsogian Prolonged exposure to volatile anesthetic isoflurane worsens the outcome of polymicrobial abdominal sepsis Toxicol. Sci, 2016;0(0):. 2016 [PMID: 28003439] (Bioassay, Human) Bioassay Human
Peter Adriaensen Enhanced Biosensor Platforms for Detecting the Atherosclerotic Biomarker VCAM1 Based on Bioconjugation with Uniformly Oriented VCAM1-Targeting Nanobodies Biosensors (Basel), 2016;6(3):. 2016 [PMID: 27399790] (Bioassay, Human) Bioassay Human
María Luisa Lozano Novel mutations in RASGRP2 encoding for CalDAG-GEFI abrogate Rap1 activation causing platelet dysfunction Blood, 2016;0(0):. 2016 [PMID: 27235135] (Bioassay, Human) Bioassay Human
Mukovozov I, Huang Y, Zhang Q, Liu G, Siu A, Sokolskyy Y, Patel S, Hyduk S, Kutryk M, Cybulsky M, Robinson L The Neurorepellent Slit2 Inhibits Postadhesion Stabilization of Monocytes Tethered to Vascular Endothelial Cells. J Immunol, 2015;195(7):3334-44. 2015 [PMID: 26297762] (Bioassay, Human) Bioassay Human
Show All 17 Publications.

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Gene Symbol VCAM1