Integrin alpha L/CD11a Antibody (MEM-25)


Flow Cytometry: Integrin alpha L/CD11a Antibody (MEM-25) [NB500-328] - Analysis using the PE conjugate of NB500-328. Surface staining of human peripheral blood cells with anti-human CD11a (MEM-25) PE.

Product Details

Reactivity HuSpecies Glossary
Applications Flow, Func, IP
1.0 mg/ml

Integrin alpha L/CD11a Antibody (MEM-25) Summary

Leucocytes from a patient suffering from a LGL-type leukemia (NM_001114380.1).
The antibody MEM-25 reacts with CD11a (alpha subunit of human LFA-1), a 170-180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils. HLDA IV; WS Code NL 209
Protein A purified
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
PBS [pH 7.4]
15mM Sodium Azide
1.0 mg/ml
Protein A purified


Application Notes
Purity is > 95% (by SDS-PAGE). Immunoprecipitation - excellent antibody for immunoaffinity purification of LFA-1 complex Functional Application - The antibody MEM-25 partially blocks binding of LFA-1 complex to ICAM-1.
Read Publications using NB500-328.

Alternate Names for Integrin alpha L/CD11a Antibody (MEM-25)

  • CD11 antigen-like family member A
  • CD11a antigen
  • CD11a
  • CD11Aantigen CD11A (p180), lymphocyte function-associated antigen 1, alphapolypeptide
  • integrin alpha-L
  • integrin gene promoter
  • integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen1; alpha polypeptide)
  • Leukocyte adhesion glycoprotein LFA-1 alpha chain
  • Leukocyte function-associated molecule 1 alpha chain
  • LFA-1 alpha
  • LFA-1
  • LFA1A
  • LFA-1A
  • Ly-15
  • Ly-21
  • lymphocyte function-associated antigen 1


CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation; binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Integrin alpha L/CD11a Antibody (NB500-328)(9)

Showing Publications 1 - 9 of 9.
Publications using NB500-328 Applications Species
Aubert M, Yoon M, Sloan DD et al. The virological synapse facilitates herpes simplex virus entry into T cells J Virol
Mathison RD, Befus AD, Davison JS, Woodman RC. Modulation of neutrophil function by the tripeptide feG BMC Immunol
Hajishengallis G, Martin M, Sojar HT et al. Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction Clin Diagn Lab Immunol
Garnotel R, Rittie L, Poitevin S et al. Human blood monocytes interact with type I collagen through alpha x beta 2 integrin (CD11c-CD18, gp150-95) J Immunol
Wang JH, Kwas C, Wu L. Intercellular adhesion molecule 1 (ICAM-1), but not ICAM-2 and -3, is important for dendritic cell-mediated human immunodeficiency virus type 1 transmission J Virol
Ottonello L, Epstein AL, Dapino P et al. Monoclonal Lym-1 antibody-dependent cytolysis by neutrophils exposed to granulocyte-macrophage colony-stimulating factor: intervention of FcgammaRII (CD32), CD11b-CD18 integrins, and CD66b glycoproteins Blood
Ottonello L, Epstein AL, Mancini M et al. Monoclonal LYM-1 antibody-dependent cytolysis by human neutrophils exposed to GM-CSF: auto-regulation of target cell attack by cathepsin G J Leukoc Biol
Simon SI, Cherapanov V, Nadra I et al. Signaling functions of L-selectin in neutrophils: alterations in the cytoskeleton and colocalization with CD18 J Immunol
Bazil V, Stefanova I, Hilgert I et al. Monoclonal antibodies against human leucocyte antigens IV Antibodies against subunits of the LFA-1 (CD11a/CD18) leucocyte-adhesion glycoprotein Folia Biol (Praha) Jun 12 1905 12:00AM

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB500-328AF405
Alexa Fluor (R) 488 Labeled NB500-328AF488
Alexa Fluor (R) 647 Labeled NB500-328AF647
Alexa Fluor (R) 700 Labeled NB500-328AF700
Biotin Labeled NB110-81625
FITC Labeled NB500-636
PE Labeled NB500-635

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