TNF alpha

Pathway Highlight: Which caspase substrates contribute to the morphological features associated with apoptosis?

Apoptosis, or programmed cell death, is controlled by a caspase signal cascade that activates downstream signals to induce the morphological changes used to differentiate apoptosis from other forms of cell death.  Novus Biologicals offers a variety of antibodies and tools to detect the different morphological indicators of cell death. 

Topics in CD11b: The innate immune response

Integrins are transmembrane receptors composed of alpha and beta chains, where beta-integrins are mainly expressed in leukocytes. Leukocytes are white blood cells that act in the immune system to defend our body against foreign pathogens.

TNF alpha (tumor necrosis factor alpha, cachectin, macrophage cytotoxic factor (MCF))

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF)-receptor superfamily. It is involved in the regulation of a wide spectrum of biological processes: cell proliferation, differentiation, apoptosis, inflammation, lipid metabolism, and coagulation. TNF alpha has been implicated in a variety of autoimmune diseases (rheumatoid arthritis, Crohn's disease, multiple sclerosis, and psoriasis), insulin resistance, septic shock, and tumor metastases related to cancer.

CD11b: Marker for a New Type of B Cell that Participates in Cell-Mediated Immunity

Think B lymphocytes just produce antibodies? Think again! Although, of course, B cells are vital for the humoral immune response, many studies in recent years have begun to uncover antibody-independent actions of B cells: regulating T cells and thus also playing a part in cellular immunity. For example, B cell depletion therapy, a new treatment for autoimmune disorders, has been found to influence T cells in addition to antibody titers.

Monocyte Chemoattractant Protein 1 in Immune System Response

MCP1, also known as CCL2, is a small chemokine factor belonging to the CC chemokine family. It is predominantly produced by endothelial cells and macrophages, and specifically is a chemoattractant for monocytes and basophils. It is produced by a wide range of cell types in reaction to diverse inflammatory stimuli including tissue injury, infection, and inflammation.

"Get the skinny" on Adiponectin & Leptin Antibodies

Simplifying IL6 Antibody Assays with ELISA kits

Interleukin 6 is a complex pleiotropic cytokine having both anti and pro-inflammatory effects. Alterations in expression contribute to many human diseases, and the IL6 antibody is widely used in the research areas of innate and adaptive immunity, autoimmune disorders; CAD (coronary artery disease); neurological disorders; cancer and inflammatory disease.

Adiponectin Antibody: Not Such a Weighty Issue

Adiponectin (also called AdipoQ and Acrp30) is a circulating cytokine primarily expressed in adipose tissue. A complex protein with a number of physiological roles, adiponectin antibody experiments have revealed multiple forms of the protein in circulation, including trimers, multioligomers and cleavage fragments. We at Novus Biologicals stock an extensive range of adiponectin antibodies, as well as recombinant proteins and ELISA adiponectin antibody kits.

TNF Alpha Antibodies: Potential Therapeutic Tools

Tumor necrosis factor alpha, or TNF alpha antibody products are widely used in cytokine and immunology research. TNF alpha is a pleiotropic ligand which plays an essential role in apoptosis, immune system development and the inflammatory response.

TNF Alpha Antibodies as Therapeutic Tools

Tumor Necrosis Factor alpha (TNFa) is a cytokine protein that plays an essential role in inducing the systemic inflammatory response, being expressed in tissues throughout the body. In autoimmune diseases such as rheumatoid arthritis and psoriasis, TNF alpha causes negative clinical effects. These can be controlled by inhibitory TNF antibody drugs, a number of which are now on the market. We at Novus Biologicals have an extensive range of TNF alpha antibodies.