Recombinant Human/Mouse/Rat GDF-11/BMP-11 Protein


1 μg/lane of Recombinant Human/Mouse/Rat GDF‑11/BMP-11 was resolved withSDS-PAGE under reducing (R) andnon-reducing (NR) conditions and visualized by silver staining, showing bands at 13 kDa and 21 kDa, respectively.
Recombinant Human/Mouse/RatGDF‑11/BMP‑11 (Catalog # 1958-GD) induces hemoglobin expression in the K562 human chronic myelogenous leukemia cell line. The ED50 for this effect is 0.8-4.8 ng/mL.
ESI analysis of Recombinant Human/Mouse/Rat GDF-11/BMP-11. The peak at 25163 Da corresponds to the calculated molecular mass of the disulfide-linked homodimer.

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications Bioactivity

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Recombinant Human/Mouse/Rat GDF-11/BMP-11 Protein Summary

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Details of Functionality
Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. et al. (1991) Method Enzymol. 198:340. The ED50 for this effect is 0.8-4.8 ng/mL.
E. coli-derived GDF-11/BMP-11 protein
Asn299-Ser407, with an N-terminal Met
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.


Theoretical MW
12.6 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
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1958-GD in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human/Mouse/Rat GDF-11/BMP-11 Protein

  • BMP11
  • BMP-11
  • BMP-11BMP11Bone morphogenetic protein 11
  • GDF11
  • GDF-11
  • growth differentiation factor 11
  • growth/differentiation factor 11


Growth Differentiation Factor 11 (GDF-11), also known as BMP-11, is a member of the TGF-beta superfamily and is highly related to GDF-8. GDF-11 encodes a 407 amino acid (aa) prepropeptide which contains a signal sequence for secretion and an RXXR proteolytic processing site to yield a 109 aa residue carboxy-terminal mature protein (1). Mature GDF-11 contains the canonical 7-cysteine motif common to other TGF-beta superfamily members; however, like the TGF-beta s, Activins and GDF-8, GDF-11 also contains one extra pair of cysteine residues. At the amino acid sequence level, mature human, mouse, rat and chicken GDF-11 are 99-100% identical. GDF-11 and GDF-8 share 90% amino acid sequence identity within the mature protein. As detected by in situ hybridization, GDF-11 is expressed in diverse regions of the mouse embryo: tailbud, somitic precursors, limbs, mandibular and branchial arches, dorsal neural tube, odontoblasts, nasal epithelium, and particular regions of the brain (1, 2). Targeted deletion of GDF-11, in mice, results in a spectrum of abnormalities including palatal malformation, vertebral defects, elongated trunks with a reduced or absent tail, missing or malformed kidneys, and an increased number of neurons in the olfactory epithelium (2-5). GDF-11 signals through the Activin type II receptors and induces phosphorylation of Smad2 to mediate axial patterning (6). Systemic GDF-11 levels decline with age and administration of higher levels of GDF-11 can reverse age-related cardiac hypertrophy (7). In addition, systemic administration of recombinant GDF-11 protein restores genomic integrity and health of muscle stem cells, neurovasculature and enhances neurogenesis (8, 9). R&D Systems recombinant GDF-11 preparations have been shown to act similarly to GDF-8 in both the Xenopus animal cap and the K562 assays.
  1. Gamer, L.W. et al. (1999) Dev. Biol. 208: 222. 
  2. Nakashima, M. et al. (1999) Mech. Dev. 80:185.  
  3. Gad, J.M. and P.P.L. Tam (1999) Curr. Biol. 9:R783.  
  4. McPherron, A.C. et al. (1999) Nat. Genet. 22:260.
  5. Esquela, A.F. and S.J. Lee (2003) Dev. Biol. 257:356.
  6. Oh, S.P. et al. (2002) Genes & Dev. 16:274.
  7. Loffredo, F.S. et. al. (2013) Cell. 153.828.
  8. Katsimpardi, L. et. al. (2014) Science (ahead of print).
  9. Sinha, M. et. al. (2014) Science (ahead of print).

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Publications for GDF-11/BMP-11 (1958-GD)(21)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Xenopus.

We have publications tested in 4 applications: Bioassay, Immunocapture LCMS Standard, Surface Plasmon Resonance, Western Blot.

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Surface Plasmon Resonance
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Showing Publications 1 - 10 of 21. Show All 21 Publications.
Publications using 1958-GD Applications Species
G De Rosa, I Andolfo, R Marra, F Manna, BE Rosato, A Iolascon, R Russo RAP-011 Rescues the Disease Phenotype in a Cellular Model of Congenital Dyserythropoietic Anemia Type II by Inhibiting the SMAD2-3 Pathway Int J Mol Sci, 2020;21(15):. 2020 [PMID: 32759740] (Bioassay, Human) Bioassay Human
Q Jin, C Qiao, J Li, B Xiao, J Li, X Xiao A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice Skelet Muscle, 2019;9(1):16. 2019 [PMID: 31133057] (Bioassay, Human) Bioassay Human
JH Kim, JH Kim, LA Sutikno, SB Lee, DH Jin, YK Hong, YS Kim, HJ Jin Identification of the minimum region of flatfish myostatin propeptide (Pep45-65) for myostatin inhibition and its potential to enhance muscle growth and performance in animals PLoS ONE, 2019;14(4):e0215298. 2019 [PMID: 30998775] (Bioassay, Human) Bioassay Human
XJ Zhang, H Tan, ZF Shi, N Li, Y Jia, Z Hao Growth differentiation factor 11 is involved in isoproterenol?induced heart failure Mol Med Rep, 2019;0(0):. 2019 [PMID: 30942402] (Bioassay, Rat) Bioassay Rat
L Qian, H Zhang, Y Gu, D Li, S He, H Wang, Y Cheng, W Yang, H Yu, X Zhao, W Cai, L Meng, M Jin, Y Wang, Y Zhang Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice Aging (Albany NY), 2018;0(0):. 2018 [PMID: 30513510] (Bioassay, Mouse) Bioassay Mouse
YJ Kim, DH Seo, SH Lee, SH Lee, GH An, HJ Ahn, D Kwon, KW Seo, KS Kang Conditioned media from human umbilical cord blood-derived mesenchymal stem cells stimulate rejuvenation function in human skin Biochem Biophys Rep, 2018;16(0):96-102. 2018 [PMID: 30417126] (Bioassay, Human) Bioassay Human
K Sakamoto, Y Kanematsu-, Y Kamada, M Oka, T Ohnishi, M Miwa, T Asami, H Inooka Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology Biochem Biophys Rep, 2017;11(0):33-39. 2017 [PMID: 28955765] (Bioassay, Human) Bioassay Human
E De Domenic, G D'Arcangel, I Faraoni, M Palmieri, V Tancredi, G Graziani, P Grimaldi, L Tentori Modulation of GDF11 expression and synaptic plasticity by age and training Oncotarget, 2017;8(35):57991-58002. 2017 [PMID: 28938532] (Western Blot, Mouse) Western Blot Mouse
JL Chen, KL Walton, A Hagg, TD Colgan, K Johnson, H Qian, P Gregorevic, CA Harrison Specific targeting of TGF-? family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):. 2017 [PMID: 28607086] (Bioassay, Human) Bioassay Human
Y Zhao, G Liu, FC Zambito, YJ Zhang, BS DeSilva, AT Kozhich, JX Shen A multiplexed immunocapture liquid chromatography tandem mass spectrometry assay for the simultaneous measurement of myostatin and GDF-11 in rat serum using an automated sample preparation platform Anal. Chim. Acta, 2017;979(0):36-44. 2017 [PMID: 28599707] (Immunocapture LCMS Standard, Rat) Immunocapture LCMS Standard Rat
Show All 21 Publications.

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Gene Symbol GDF11