Activin RIIB Antibody

Images

 
Activin RIIB was detected in immersion fixed paraffin-embedded sections of human placenta (cross-section of chorionic villi) using 5 µg/mL Goat Anti-Human Activin RIIB Antigen Affinity-purified Poly­clonal Antibody ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, B/N
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
View Available Formulations
Catalog# & Formulation Size Price

Activin RIIB Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Activin RIIB
Ser19-Thr134
Accession # CAA54671
Specificity
Detects human Activin RIIB in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse Activin RIIB is observed, and less than 1% cross-reactivity with recombinant human (rh) Activin RIIA, rhActivin RIA, and rhActivin RIB is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
ACVR2B
Purity
Immunogen affinity purified
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Immunohistochemistry 5-15 ug/mL
  • Blockade of Receptor-ligand Interaction
Reviewed Applications
Read 1 Review rated 4
using
AF339 in the following applications:

Publications
Read Publications using
AF339 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Activin RIIB Antibody

  • activin A receptor, type IIB
  • Activin receptor type IIB
  • activin receptor type-2B
  • Activin RIIB
  • ActivinRIIB
  • ACTRIIB
  • ActR-IIB
  • ACVR2B
  • EC 2.7.11
  • EC 2.7.11.30
  • MGC116908

Background

Activin isoforms and other members of the TGF-beta  superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine‑threonine kinase receptor, both of which are essential for signal transduction. Seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActR-I(A), ActR-IB, ActR-II(A) and ActR-IIB, have been cloned from mammals. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated, adding to the complexity of the activin receptor system. Different activin isoforms bind with different high-affinities to the various type II isoforms. Type I activin receptors do not bind directly to activin, but will associate with the type II receptor-activin complex and initiate signal transduction. Besides the activin isoforms, ActR-II will also bind inhibin, BMP-2 and BMP-7 with lower affinities. ActR-I can also bind and form signaling complexes with the BMP‑2/7‑bound BMPR-II. Activin type II receptors are highly conserved. Human, mouse and rat type II activin receptors share greater than 98% amino acid sequence homology. Recombinant soluble activin type II receptors bind activin with high affinity, and are potent activin antagonists.

  1. Attisano, L. et al. (1996) Mol. and Cell Biol. 16:1066.
  2. Woodruff, T.K. (1998) Biochem. Pharmacology 55:953.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

AF340
Species: Hu
Applications: WB, IHC, Block
AF222
Species: Hu
Applications: WB, Block
AF637
Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready
AF3797
Species: Hu, Mu
Applications: WB, Simple Western, ChIP, ICC
AF811
Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready
AF346
Species: Hu
Applications: WB, Flow, CyTOF-ready
NBP2-14889
Species: Hu, Mu, Rt, Bv
Applications: WB, IHC, IHC-Fr, IHC-P
AF-242-PB
Species: Hu
Applications: WB, Flow, CyTOF-ready
NBP2-29463
Species: Hu, Mu, Rt, Pm
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P

Publications for Activin RIIB Antibody (AF339)(5)

We have publications tested in 4 confirmed species: Mouse, Rat, Feline, Ovine.

We have publications tested in 3 applications: IHC Paraffin-embedded, IP, WB.


Filter By Application
IHC Paraffin-embedded
(2)
IP
(1)
WB
(2)
All Applications
Filter By Species
Mouse
(2)
Rat
(1)
Feline
(1)
Ovine
(1)
All Species

Review for Activin RIIB Antibody (AF339) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Other.

Reviews using AF339:
Filter by Applications
IHC-P
(1)
All Applications
Filter by Species
Other
(1)
All Species
Images Ratings Applications Species Date Details
Immunohistochemistry-Paraffin Activin RIIB AF339
Enlarge
reviewed by:
Anonymous
IHC-P Other 04/02/2015
View

Summary

ApplicationImmunohistochemistry-Paraffin
Sample Testedbovine fetal ovary
SpeciesOther
LotBav0413081

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Activin RIIB Antibody (AF339) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Array Products

Bioinformatics Tool for Activin RIIB Antibody (AF339)

Discover related pathways, diseases and genes to Activin RIIB Antibody (AF339). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Activin RIIB Antibody (AF339)

Discover more about diseases related to Activin RIIB Antibody (AF339).
 

Pathways for Activin RIIB Antibody (AF339)

View related products by pathway.

PTMs for Activin RIIB Antibody (AF339)

Learn more about PTMs related to Activin RIIB Antibody (AF339).

Blogs on Activin RIIB

There are no specific blogs for Activin RIIB, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Recent Reviews

4
5
0
4
1
3
0
2
0
1
0

Anonymous
04/02/2015
Application: IHC-P
Species: Other

Bioinformatics

Gene Symbol ACVR2B
Entrez
Uniprot