BMP-1/PCP Antibody [Unconjugated]


Western blot shows 25 ng of Recombinant Human BMP‑1/PCP (Catalog # 1927-ZN), Recombinant Human TLL-2, Recombinant Human/Mouse/Rat BMP‑2 (Catalog # 355-BM), Recombinant Human BMP‑3 (Catalog # 113-BP), more
Western blot shows 25 ng of Recombinant Human BMP‑1/PCP (Catalog # 1927-ZN), Recombinant Human TLL-2, Recombinant Human Meprin alpha Subunit/MEP1A (Catalog # 3220-ZN), Recombinant Human Meprin beta more

Product Details

Reactivity HuSpecies Glossary
Applications WB, IP

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BMP-1/PCP Antibody [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant human BMP‑1/PCP
Accession # NP_001190
Detects human BMP‑1/PCP direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant human (rh) TLL-2 is observed, and less than 1% cross-reactivity with rhBMP-2, -3, -3b, -4, -5, -6, -7, -8, -9, -10, and -15 is observed.
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Immunoprecipitation 25 ug/mL
  • Western Blot 0.1 ug/mL
Read Publications using
AF1927 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BMP-1/PCP Antibody [Unconjugated]

  • BMP1
  • BMP-1
  • bone morphogenetic protein 1
  • EC 3.4.24
  • EC
  • FLJ44432
  • Mammalian tolloid protein
  • mTld
  • PCP
  • PCP2
  • procollagen C-endopeptidase
  • Procollagen C-proteinase
  • TLD


Bone morphogenetic protein 1 (BMP-1), also known as procollagen C-proteinase (PCP), is a zinc protease of the astacin family (1, 2). BMP-1/PCP plays a key role in formation of extracellular matrix (ECM) by converting precursor proteins into their mature and functional forms. The precursor proteins identified as substrates for BMP-1/PCP include collagens, biglycan, laminin 5, dentin matrix protein-1, and lysyl oxidase (3). There are six alternatively spliced forms known to be derived from the BMP-1 gene, and isoform 1 consisting of residues 1 to 730 was expressed. The secreted and purified protein does not contain the signal peptide (amino acid residues 1‑22) and pro domain (residues 23‑120), but contain protease (residues 121‑321), CUB I (residues 322‑434), CUB II (residues 435‑546), EGF-like (residues 547‑588) and CUB III (residues 591‑703) domains. The pro domain is apparently cleaved by a furin-like proprotein convertase (4). The purified BMP-1/PCP is an active protease and its peptidase activity can be determined as described above. The purified BMP-1/PCP is predicted to possess procollagen C-proteinase activity because it contains the minimal domain structure required (5).

  1. Wozney, J.M. et al. (1988) Science 242:1528.
  2. Bond, J.S. and R.J. Beynon (1995) Protein Sci. 4:1247.
  3. Steiglitz, B.M. et al. (2004) J. Biol. Chem. 279:980.
  4. Leighton, M. and K.E. Kadler (2003) J. Biol. Chem. 278:18478.
  5. Hartigan, N. et al. (2003) J. Biol. Chem. 278:18045.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for BMP-1/PCP Antibody (AF1927)(6)

We have publications tested in 2 confirmed species: Human, Porcine.

We have publications tested in 1 application: Western Blot.

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Showing Publications 1 - 6 of 6.
Publications using AF1927 Applications Species
T Rosell-Gar, A Paradela, G Bravo, L Dupont, M Bekhouche, A Colige, F Rodriguez- Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain J. Biol. Chem., 2019;0(0):. 2019 [PMID: 31152061] (Western Blot, Human) Western Blot Human
T Rosell-Gar, F Rodriguez- Enhancement of collagen deposition and cross-linking by coupling lysyl oxidase with bone morphogenetic protein-1 and its application in tissue engineering Sci Rep, 2018;8(1):10780. 2018 [PMID: 30018337] (Western Blot) Western Blot
Syx D, Guillemyn B, Symoens S, Sousa A, Medeira A, Whiteford M, Hermanns-Le T, Coucke P, De Paepe A, Malfait F Defective Proteolytic Processing of Fibrillar Procollagens and Prodecorin Due to Biallelic BMP1 Mutations Results in a Severe, Progressive Form of Osteogenesis Imperfecta. J Bone Miner Res, 2015;30(8):1445-56. 2015 [PMID: 25656619] (Western Blot, Human) Western Blot Human
Hirako Y, Yonemoto Y, Yamauchi T, Nishizawa Y, Kawamoto Y, Owaribe K Isolation of a hemidesmosome-rich fraction from a human squamous cell carcinoma cell line. Exp Cell Res, 2014;324(2):172-82. 2014 [PMID: 24726610] (Western Blot, Human) Western Blot Human
Tsuchiya S, Simmer JP, Hu JC, Richardson AS, Yamakoshi F, Yamakoshi Y Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp). J. Bone Miner. Res., 2010;26(0):220. 2010 [PMID: 20687161] (Western Blot, Porcine) Western Blot Porcine
Von Marschall Z, Fisher LW Dentin matrix protein-1 isoforms promote differential cell attachment and migration. J. Biol. Chem., 2008;283(47):32730-40. 2008 [PMID: 18819913] (Western Blot, Human) Western Blot Human

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Gene Symbol BMP1