Activin RIIA Antibody


Activin RIIA was detected in immersion fixed paraffin-embedded sections of human prostate cancer tissue using 15 µg/mL Goat Anti-Human Activin RIIA Antigen Affinity-purified Polyclonal Antibody (Catalog # AF340) more

Product Details

Reactivity HuSpecies Glossary
Applications WB, IHC, B/N

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
View Available Formulations
Catalog# & Formulation Size Price

Activin RIIA Antibody Summary

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Activin RIIA
Accession # P27037
Detects human Activin RIIA in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 2% cross-reactivity with recombinant human Activin RIIB is observed.
Immunogen affinity purified
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 0.1 ug/mL
  • Immunohistochemistry 5-15 ug/mL
  • Blockade of Receptor-ligand Interaction
Activin RIIA Knockout HeLa Cell Lysate
Read Publications using
AF340 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
No Preservative
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Activin RIIA Antibody

  • activin A receptor, type II
  • activin A receptor, type IIA
  • Activin receptor type IIA
  • activin receptor type-2A
  • Activin RIIA
  • ActivinRIIA
  • ACVR2A
  • AVR2A
  • EC 2.7.11
  • EC


Activin isoforms and other members of the TGF-beta  superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. To date, seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActR-I(A), ActR-IB, ActR-II(A) and ActR-IIB, have been cloned from mammals. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated, adding to the complexity of the activin receptor system. Different activin isoforms bind with different high-affinities to the various type II isoforms. Type I activin receptors do not bind directly to activin, but will associate with the type II receptor-activin complex and initiate signal transduction. Besides the activin isoforms, ActR-II will also bind inhibin, BMP-2 and BMP-7 with lower affinities. ActR-I can also bind and form signaling complexes with the BMP-2/7-bound BMPR-II. Activin type II receptors are highly conserved. Human, mouse and rat type II activin receptors share greater than 98% amino acid sequence homology. Recombinant soluble activin type II receptors bind activin with high affinity, and are potent activin antagonists.

  1. Attisano, L. et al. (1996) Mol. and Cell. Biol. 16:1066.
  2. Woodruff, T.K. (1998) Biochem. Pharmacology, 55:953.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: WB, IHC, Block
Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready
Species: Hu
Applications: WB, Block, KO
Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready, ELISA(Cap), ELISA(Det), Neut, ELISA(Sta)
Species: Hu
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Species: Hu, Mu
Applications: WB, Simple Western, ChIP, ICC
Species: Hu, Mu
Applications: WB, Flow, ICC/IF
Species: Hu, Mu, Rt

Publications for Activin RIIA Antibody (AF340)(6)

We have publications tested in 4 confirmed species: Mouse, Rat, Feline, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque).

We have publications tested in 5 applications: Cell Culture, ELISA Development, IHC-P, Immunoprecipitation, Western Blot.

Filter By Application
Cell Culture
ELISA Development
Western Blot
All Applications
Filter By Species
Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
All Species
Showing Publications 1 - 6 of 6.
Publications using AF340 Applications Species
A Dillenburg, G Ireland, RK Holloway, CL Davies, FL Evans, M Swire, ME Bechler, D Soong, TJ Yuen, GH Su, JC Becher, C Smith, A Williams, VE Miron Activin receptors regulate the oligodendrocyte lineage in health and disease Acta Neuropathol., 2018;0(0):. 2018 [PMID: 29397421] (Cell Culture, Mouse) Cell Culture Mouse
Fajardo RJ, Manoharan RK, Pearsall RS, Davies MV, Marvell T, Monnell TE, Ucran JA, Pearsall AE, Khanzode D, Kumar R, Underwood KW, Roberts B, Seehra J, Bouxsein ML Treatment with a soluble receptor for activin improves bone mass and structure in the axial and appendicular skeleton of female cynomolgus macaques (Macaca fascicularis). Bone, 2010;46(1):64-71. 2010 [PMID: 19781677] (ELISA Development, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)) ELISA Development Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Bristol-Gould SK, Kreeger PK, Selkirk CG, Kilen SM, Cook RW, Kipp JL, Shea LD, Mayo KE, Woodruff TK Postnatal regulation of germ cells by activin: the establishment of the initial follicle pool. Dev. Biol., 2006;298(1):132-48. 2006 [PMID: 16930587] (IHC-P, Mouse) IHC-P Mouse
Maeshima A, Vaughn DA, Choi Y, Nigam SK Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 2006;295(2):473-85. 2006 [PMID: 16643884] (Western Blot, Rat) Western Blot Rat
Bristol SK, Woodruff TK Follicle-restricted compartmentalization of transforming growth factor beta superfamily ligands in the feline ovary. Biol. Reprod., 2004;70(3):846-59. 2004 [PMID: 14656728] (IHC-P, Feline) IHC-P Feline
Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway. J. Biol. Chem., 2002;277(21):19008-18. 2002 [PMID: 11882656] (Immunoprecipitation, Mouse) Immunoprecipitation Mouse

Reviews for Activin RIIA Antibody (AF340) (0)

There are no reviews for Activin RIIA Antibody (AF340). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Activin RIIA Antibody (AF340) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Biotin BAF340

Additional Activin RIIA Products

Bioinformatics Tool for Activin RIIA Antibody (AF340)

Discover related pathways, diseases and genes to Activin RIIA Antibody (AF340). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Activin RIIA Antibody (AF340)

Discover more about diseases related to Activin RIIA Antibody (AF340).

Pathways for Activin RIIA Antibody (AF340)

View related products by pathway.

PTMs for Activin RIIA Antibody (AF340)

Learn more about PTMs related to Activin RIIA Antibody (AF340).

Blogs on Activin RIIA

There are no specific blogs for Activin RIIA, but you can read our latest blog posts.
Coronavirus Brochure

Customers Who Bought This Also Bought

Contact Information

Learn the difference between western blot and simple western

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our Activin RIIA Antibody and receive a gift card or discount.


Gene Symbol ACVR2A