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Recombinant Human ICAM-1/CD54 Protein, CF


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Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human ICAM-1/CD54 Protein, CF Summary

Details of Functionality
Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells. When 5 x 104 cells/well are added to Recombinant Human ICAM‑1/CD54 coated plates (12.5 μg/mL with 100 μL/well), >30% cells will adhere after 1 hour incubation at 37 °C.
Optimal dilutions should be determined by each laboratory for each application.
Mouse myeloma cell line, NS0-derived human ICAM-1/CD54 protein
Accession #
N-terminal Sequence
Not obtained, Predicted Gln28
Protein/Peptide Type
Recombinant Proteins
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


  • Bioactivity
Theoretical MW
50 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
70-90 kDa, reducing conditions
Read Publications using
ADP4 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS, containing Calcium and Magnesium with Sorbitol and with Trehalose.
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 400 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human ICAM-1/CD54 Protein, CF

  • BB2
  • CD54 antigen
  • CD54
  • cell surface glycoprotein P3.58
  • human rhinovirus receptor
  • ICAM1
  • ICAM-1
  • intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
  • intercellular adhesion molecule 1
  • Major group rhinovirus receptor
  • P3.58


Intercellular Adhesion Molecule-1 (ICAM-1) binds the leukocyte integrins LFA-1 and Mac-1. ICAM-1 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma , TNF-alpha , IL-1 beta and LPS. Soluble ICAM-1 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation.

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Publications for ICAM-1/CD54 (ADP4)(31)

We have publications tested in 4 confirmed species: Human, Mouse, Bacteria, N/A.

We have publications tested in 7 applications: Adhesion Assay, Affinity Purification, Bioassay, ELISA (Capture), ELISA (Standard), ELISA Capture, Surface Plasmon Resonance.

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Adhesion Assay
Affinity Purification
ELISA (Capture)
ELISA (Standard)
ELISA Capture
Surface Plasmon Resonance
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Showing Publications 1 - 10 of 31. Show All 31 Publications.
Publications using ADP4 Applications Species
Lacouture, C;Chaves, B;Guipouy, D;Houmadi, R;Duplan-Eche, V;Allart, S;Destainville, N;Dupré, L; LFA-1 nanoclusters integrate TCR stimulation strength to tune T-cell cytotoxic activity Nature communications 2024-01-09 [PMID: 38195629] (Bioassay, Human) Bioassay Human
Sindram, E;Caballero-Oteyza, A;Kogata, N;Huang, S;Alizadeh, Z;Gamez-Díaz, L;Fazlollahi, MR;Peng, X;Grimbacher, B;Way, M;Proietti, M; ARPC5 deficiency leads to severe early onset systemic inflammation and mortality Disease models & mechanisms 2023-06-29 [PMID: 37382373] (Bioassay, Human) Bioassay Human
L Kaltenbach, P Martzloff, SK Bambach, N Aizarani, M Mihlan, A Gavrilov, KM Glaser, M Stecher, R Thünauer, A Thiriot, K Heger, K Kierdorf, S Wienert, UH von Andria, M Schmidt-Su, C Nerlov, F Klauschen, A Roers, M Bajénoff, D Grün, T Lämmermann Slow integrin-dependent migration organizes networks of tissue-resident mast cells Nature Immunology, 2023-04-20;0(0):. 2023-04-20 [PMID: 37081147] (Bioassay, Mouse) Bioassay Mouse
C Weichwald, I Zettl, I Ellinger, K Niespodzia, EE Waltl, S Villazala-, D Ivanov, J Eckl-Dorna, V Niederberg, R Valenta, S Flicker Antibody Conjugates Bispecific for Pollen Allergens and ICAM-1 with Potential to Prevent Epithelial Allergen Transmigration and Rhinovirus Infection International Journal of Molecular Sciences, 2023-02-01;24(3):. 2023-02-01 [PMID: 36769047] (ELISA Capture, Human, N/A) ELISA Capture Human, N/A
R Fitterer, T Lajqi, SA Kranig, M Braun, N Theissig, N Kuss, J Pöschl, D Frommhold, H Hudalla L-Arginine Modulates Neonatal Leukocyte Recruitment in a Gestational Age-Dependent Manner J Clin Med, 2020-08-27;9(9):. 2020-08-27 [PMID: 32867030] (Bioassay, Human) Bioassay Human
J Gamara, L Davis, E Rollet-Lab, T Hongu, Y Funakoshi, Y Kanaho, F Aoudjit, SG Bourgoin Assessment of Arf6 Deletion in PLB-985 Differentiated in Neutrophil-Like Cells and in Mouse Neutrophils: Impact on Adhesion and Migration Mediators Inflamm., 2020-04-07;2020(0):2713074. 2020-04-07 [PMID: 32322163] (Bioassay, Human) Bioassay Human
F Caccuri, A Bugatti, S Corbellini, S Roversi, A Zani, P Mazzuca, S Marsico, A Caruso, C Giagulli The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3) Int J Mol Sci, 2019-10-24;20(21):. 2019-10-24 [PMID: 31653015] (Bioassay, Human) Bioassay Human
NV Ayala-Nune, G Follain, F Delalande, A Hirschler, E Partiot, GL Hale, BC Bollweg, J Roels, M Chazal, F Bakoa, M Carocci, S Bourdoulou, O Faklaris, SR Zaki, A Eckly, B Uring-Lamb, F Doussau, S Cianferani, C Carapito, FMJ Jacobs, N Jouvenet, JG Goetz, R Gaudin Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells Nat Commun, 2019-09-27;10(1):4430. 2019-09-27 [PMID: 31562326] (Bioassay, Human) Bioassay Human
MJ Bertrand, M Abran, F Maafi, D Busseuil, N Merlet, T Mihalache-, P Geoffroy, PL Tardif, A Abulrob, M Arbabi-Gha, F Ni, M Sirois, PL L'Allier, É Rhéaume, F Lesage, JC Tardif In Vivo Near-Infrared Fluorescence Imaging of Atherosclerosis Using Local Delivery of Novel Targeted Molecular Probes Sci Rep, 2019-02-25;9(1):2670. 2019-02-25 [PMID: 30804367] (Affinity Purification, Human) Affinity Purification Human
D Wolf, N Anto-Miche, H Blankenbac, A Wiedemann, K Buscher, JD Hohmann, B Lim, M Bäuml, A Marki, M Mauler, D Duerschmie, Z Fan, H Winkels, D Sidler, P Diehl, DM Zajonc, I Hilgendorf, P Stachon, T Marchini, F Willecke, M Schell, B Sommer, C von Zur Mu, J Reinöhl, T Gerhardt, EF Plow, V Yakubenko, P Libby, C Bode, K Ley, K Peter, A Zirlik A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense Nat Commun, 2018-02-06;9(1):525. 2018-02-06 [PMID: 29410422] (Bioassay, Human) Bioassay Human
Show All 31 Publications.

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Gene Symbol ICAM1