Recombinant Human ICAM-1/CD54 Fc Chimera Protein, CF

1 μg/lane of Recombinant HumanICAM-1/CD54 Fc Chimera was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing bands at 110 kDa and 190 kDa, respectively.

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human ICAM-1/CD54 Fc Chimera Protein, CF Summary

• Details of Functionality: Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells. When 5 x 10 4 cells/well are added to recombinant human ICAM Fc Chimera coated plates (12.5 µg/mL with 100 µL/well), >60% will adhere after PMA 1 hour incubation at 37 degreesC. Optimal dilutions should be determined by each laboratory for each application.
• Source: Mouse myeloma cell line, NS0-derived human ICAM-1/CD54 protein

  Human ICAM-1 Gln28-Glu480 Accession # CAA30051

  IEGRMD

  Human IgG 1 (Pro100-Lys330)

  N-terminus

  C-terminus

• Accession #: CAA30051
• N-terminal Sequence: No results obtained: Gln28 predicted
• Structure / Form: Disulfide-linked homodimer
• Protein/Peptide Type: Recombinant Proteins
• Gene: ICAM1
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 76 kDa (monomer).
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 110-125 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 12 weeks, -20 to -70 degreesC under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Reconstitution Instructions: Reconstitute at 400 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human ICAM-1/CD54 Fc Chimera Protein, CF

• BB2
• CD54 antigen
• CD54
• cell surface glycoprotein P3.58
• human rhinovirus receptor
• ICAM1
• ICAM-1
• intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
• intercellular adhesion molecule 1
• Major group rhinovirus receptor
• P3.58

Background

Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac-1. ICAM-1 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma , TNF-alpha , IL-1 beta and LPS. Soluble ICAM-1 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation.

1. Pigott, R. and C. Power, 1993, The Adhesion Molecule Facts Book, pp. 74. Academic Press.

Publications for ICAM-1/CD54 (720-IC)(65)

Publications using 720-IC

• Chouaib, AA;Chang, HF;Khamis, OM;Alawar, N;Echeverry, S;Demeersseman, L;Elizarova, S;Daniel, JA;Tian, Q;Lipp, P;Fornasiero, EF;Valitutti, S;Barg, S;Pape, C;Shaib, AH;Becherer, U; Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis Nature communications 2025-07-12 [PMID: 40651941] (Bioassay, Human)
• Barandun, N;Meier, B;Stehli, G;Gräbnitz, F;Zangger, N;Oxenius, A; Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation Cell reports 2025-01-06 [PMID: 39764850] (In vitro assay, Mouse)
• Jürgens, M;Claus, M;Wingert, S;Niemann, JA;Picard, LK;Hennes, E;Haasler, I;Hellwig, B;Overbeck, N;Reinders, J;Rahnenführer, J;Schedel, M;Capellino, S;Watzl, C; Chronic stimulation desensitizes ?2-adrenergic receptor responses in natural killer cells European journal of immunology 2024-09-30 [PMID: 39350450] (Bioassay, Human)
• Wilkins, GC;Gilmour, J;Giannoudaki, E;Kirby, JA;Sheerin, NS;Ali, S; Dissecting the Therapeutic Mechanisms of Sphingosine-1-Phosphate Receptor Agonism during Ischaemia and Reperfusion International journal of molecular sciences 2023-07-07 [PMID: 37446370] (Bioassay, Human)
• Toffali, L;D'Ulivo, B;Giagulli, C;Montresor, A;Zenaro, E;Delledonne, M;Rossato, M;Iadarola, B;Sbarbati, A;Bernardi, P;Angelini, G;Rossi, B;Lopez, N;Linke, WA;Unger, A;Di Silvestre, D;Benazzi, L;De Palma, A;Motta, S;Constantin, G;Mauri, P;Laudanna, C; An isoform of the giant protein titin is a master regulator of human T lymphocyte trafficking Cell reports 2023-05-18 [PMID: 37204926] (Bioassay, Human)
• Gr�bnitz, F;Stark, D;Shlesinger, D;Petkidis, A;Borsa, M;Yermanos, A;Carr, A;Barandun, N;Wehling, A;Balaz, M;Schroeder, T;Oxenius, A; Asymmetric cell division safeguards memory CD8 T�cell development Cell reports 2023-05-12 [PMID: 37178119] (Bioassay, Mouse)
• I Rohwedder, LM Wackerbart, K Heinig, A Ballweg, J Altstätter, M Ripphahn, C Nussbaum, M Salvermose, S Bierschenk, T Straub, M Gunzer, M Schmidt-Su, T Kolben, C Schulz, A Ma, B Walzog, M Heinig, M Sperandio A20 and the non-canonical NF-kappaB pathway are key regulators of neutrophil recruitment during fetal ontogeny JCI Insight, 2023-02-22;0(0):. 2023-02-22 [PMID: 36633909] (Bioassay, Human)
• VA Morikis, SJ Chen, J Madigan, MH Jo, LC Werba, T Ha, SI Simon beta2-Integrin Adhesive Bond Tension under Shear Stress Modulates Cytosolic Calcium Flux and Neutrophil Inflammatory Response Cells, 2022-09-09;11(18):. 2022-09-09 [PMID: 36139397] (Bioassay, Human)
• L Wen, A Marki, Z Wang, M Orecchioni, J Makings, M Billitti, E Wang, SSA Suthahar, K Kim, WB Kiosses, Z Mikulski, K Ley A humanized beta2 integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in�vivo Cell Reports, 2022-05-31;39(9):110876. 2022-05-31 [PMID: 35649374] (Bioassay, Human)
• M Mastrogiov, P Vargas, T Rose, C Cuche, E Esposito, M Juzans, H Laude, A Schneider, M Bernard, S Goyard, C Renaudat, MN Ungeheuer, J Delon, A Alcover, V Di Bartolo The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration Science Advances, 2022-04-13;8(15):eabl5942. 2022-04-13 [PMID: 35417240] (Bioassay, Human)
• W Liu, AY Hsu, Y Wang, T Lin, H Sun, JS Pachter, A Groisman, M Imperioli, FW Yungher, L Hu, P Wang, Q Deng, Z Fan Mitofusin-2 regulates leukocyte adhesion and beta2 integrin activation Journal of leukocyte biology, 2021-09-08;0(0):. 2021-09-08 [PMID: 34494308] (Bioassay, Human)
• KP Eidell, A Lovy, NR Sylvain, FA Scangarell, HI Muendlein, MJ Ophir, K Nguyen, MC Seminario, SC Bunnell LFA-1 and Kindlin-3 enable the collaborative transport of SLP-76 microclusters by myosin and dynein motors Journal of Cell Science, 2021-08-27;0(0):. 2021-08-27 [PMID: 34279667] (Bioassay, Human)
• AL Lanz, G Masi, N Porciello, A Cohnen, D Cipria, D Prakaash, Š Bálint, R Raggiaschi, D Galgano, DK Cole, M Lepore, O Dushek, ML Dustin, MSP Sansom, AC Kalli, O Acuto Allosteric activation of T�cell antigen receptor signaling by quaternary structure relaxation Cell Reports, 2021-07-13;36(2):109375. 2021-07-13 [PMID: 34260912] (Bioassay, Human)
• Y German, L Vulliard, A Kamnev, L Pfajfer, J Huemer, AK Mautner, A Rubio, A Kalinichen, K Boztug, A Ferrand, J Menche, L Dupré Morphological profiling of human T and NK lymphocytes by high-content cell imaging Cell Reports, 2021-07-06;36(1):109318. 2021-07-06 [PMID: 34233185] (Bioassay, Human)
• M Borsa, N Barandun, F Gräbnitz, I Barnstorf, NS Baumann, K Pallmer, S Baumann, D Stark, M Balaz, N Oetiker, F Wagen, C Wolfrum, AK Simon, N Joller, Y Barral, R Spörri, A Oxenius Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing Nature Communications, 2021-05-11;12(1):2715. 2021-05-11 [PMID: 33976157] (Bioassay, Mouse)
• PK Myint, A Ito, MG Appiah, G Obeng, S Darkwah, E Kawamoto, A Gaowa, EJ Park, M Shimaoka Irisin supports integrin-mediated cell adhesion of lymphocytes Biochemistry and Biophysics Reports, 2021-03-08;26(0):100977. 2021-03-08 [PMID: 33732908] (Bioassay, ELISA Capture Control, Human)
• F Lafouresse, R Jugele, S Müller, M Doineau, V Duplan-Ech, E Espinosa, MP Puisségur, S Gadat, S Valitutti Stochastic asymmetric repartition of lytic machinery in dividing CD8+ T cells generates heterogeneous killing behavior Elife, 2021-01-11;10(0):. 2021-01-11 [PMID: 33427199] (Flow Cytometry, Human)
• Q Dirar, T Russell, L Liu, S Ahn, G Dotti, S Aravamudha, L Conforti, Y Yun Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces PLoS ONE, 2020-09-25;15(9):e0238819. 2020-09-25 [PMID: 32976541] (Bioassay, Human)
• A Reversat, F Gaertner, J Merrin, J Stopp, S Tasciyan, J Aguilera, I de Vries, R Hauschild, M Hons, M Piel, A Callan-Jon, R Voituriez, M Sixt Cellular locomotion using environmental topography Nature, 2020-05-13;582(7813):582-585. 2020-05-13 [PMID: 32581372] (Cell Culture, Mouse)
• M Klinger, G Zugmaier, V Nägele, ME Goebeler, C Brandl, M Stelljes, H Lassmann, A von Stacke, RC Bargou, P Kufer Adhesion of T cells to endothelial cells facilitates blinatumomab-associated neurologic adverse events Cancer Res., 2019-10-29;0(0):. 2019-10-29 [PMID: 31662326] (Bioassay, Human)
• H Sun, Z Fan, AR Gingras, MA Lopez-Rami, MH Ginsberg, K Ley Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling J. Leukoc. Biol., 2019-09-01;0(0):. 2019-09-01 [PMID: 31475386] (Bioassay, Human)
• LC Ristow, V Tran, KJ Schwartz, L Pankratz, A Mehle, JD Sauer, RA Welch The Extracellular Domain of the β2 Integrin β Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity MBio, 2019-07-09;10(4):. 2019-07-09 [PMID: 31289186] (Western Blot, Human)
• KM Wilton, BL Overlee, DD Billadeau NKG2D/DAP10 Signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity J. Cell. Sci., 2019-07-18;0(0):. 2019-07-18 [PMID: 31235500] (Bioassay, Human)
• O Theodoly, N Garcia-Sey, F Bedu, X Luo, S Gabriele, T Mignot, J Giermanska, JP Chapel, M Métivier, MP Valignat Live nanoscopic to mesoscopic topography reconstruction with an optical microscope for chemical and biological samples PLoS ONE, 2018-12-12;13(12):e0207881. 2018-12-12 [PMID: 30540777] (Bioassay, Human)
• G Saggu, K Okubo, Y Chen, R Vattepu, N Tsuboi, F Rosetti, X Cullere, N Washburn, S Tahir, AM Rosado, SM Holland, RM Anthony, M Sen, C Zhu, TN Mayadas Cis interaction between sialylated Fc?RIIA and the ?I-domain of Mac-1 limits antibody-mediated neutrophil recruitment Nat Commun, 2018-11-29;9(1):5058. 2018-11-29 [PMID: 30498196] (Bioassay, Human)
• BL Benson, L Li, JT Myers, RD Dorand, UA Gurkan, AY Huang, RM Ransohoff Biomimetic post-capillary venule expansions for leukocyte adhesion studies Sci Rep, 2018-06-19;8(1):9328. 2018-06-19 [PMID: 29921896]
• F Jahan, S Madhavan, T Rolova, L Viazmina, M Grönholm, CG Gahmberg Phosphorylation of the ?-chain in the integrin LFA-1 enables ?2-chain phosphorylation and ?-actinin binding required for cell adhesion J. Biol. Chem., 2018-06-14;0(0):. 2018-06-14 [PMID: 29903913] (Bioassay)
• CH Huang, YJ Liao, TH Fan, TJ Chiou, YH Lin, YC Twu A Developed NK-92MI Cell Line with Siglec-7negPhenotype Exhibits High and Sustainable Cytotoxicity against Leukemia Cells Int J Mol Sci, 2018-04-04;19(4):. 2018-04-04 [PMID: 29617289] (Bioassay)
• JM Laufer, R Lyck, DF Legler ZAP70 expression enhances chemokine-driven chronic lymphocytic leukemia cell migration and arrest by valency regulation of integrins FASEB J., 2018-03-28;0(0):fj201701452RR. 2018-03-28 [PMID: 29589978] (Bioassay, Cell Culture, Human)
• R Houmadi, D Guipouy, J Rey-Barros, Z Vasconcelo, J Cornet, M Manghi, N Destainvil, S Valitutti, S Allart, L Dupré The Wiskott-Aldrich Syndrome Protein Contributes to the Assembly of the LFA-1 Nanocluster Belt at the Lytic Synapse Cell Rep, 2018-01-28;22(4):979-991. 2018-01-28 [PMID: 29386139] (Bioassay, Human)
• C Arbuckle, M Greenberg, A Bergh, R German, N Sirago, E Linstead T-Time: A data repository of T cell and calcium release-activated calcium channel activation imagery BMC Res Notes, 2017-08-15;10(1):408. 2017-08-15 [PMID: 28807036] (Bioassay, Human)
• Q Yuan, C Ren, W Xu, B Petri, J Zhang, Y Zhang, P Kubes, D Wu, W Tang PKN1 Directs Polarized RAB21 Vesicle Trafficking via RPH3A and Is Important for Neutrophil Adhesion and Ischemia-Reperfusion Injury Cell Rep, 2017-06-20;19(12):2586-2597. 2017-06-20 [PMID: 28636945] (Bioassay, Goat)
• V Nägele, A Kratzer, G Zugmaier, C Holland, Y Hijazi, MS Topp, N Gökbuget, PA Baeuerle, P Kufer, A Wolf, M Klinger Changes in clinical laboratory parameters and pharmacodynamic markers in response to blinatumomab treatment of patients with relapsed/refractory ALL Exp Hematol Oncol, 2017-05-18;6(0):14. 2017-05-18 [PMID: 28533941] (Bioassay, Human)
• EE Edwards, SN Thomas P-Selectin and ICAM-1 synergy in mediating THP-1 monocyte adhesion in hemodynamic flow is length dependent Integr Biol (Camb), 2017-04-18;9(4):313-327. 2017-04-18 [PMID: 28262902] (Bioassay, Human)
• T Schober, T Magg, M Laschinger, M Rohlfs, ND Linhares, J Puchalka, T Weisser, K Fehlner, J Mautner, C Walz, K Hussein, G Jaeger, B Kammer, I Schmid, M Bahia, SD Pena, U Behrends, BH Belohradsk, C Klein, F Hauck A human immunodeficiency syndrome caused by mutations in CARMIL2 Nat Commun, 2017-01-23;8(0):14209. 2017-01-23 [PMID: 28112205] (Migration, Human)
• Recruitment of calcineurin to the TCR positively regulates T cell activation Nat. Immunol, 2016-12-12;0(0):. 2016-12-12 [PMID: 27941787] (Bioassay, Human)
• Jered Brackston Haun The evolution of multivalent nanoparticle adhesion via specific molecular interactions Langmuir, 2016-12-05;0(0):. 2016-12-05 [PMID: 27797529] (Bioassay)
• Identification of pathogenic factors potentially involved in Staphylococcus aureus keratitis using proteomics Exp Eye Res, 2016-08-30;151(0):171-178. 2016-08-30 [PMID: 27590660] (Bioassay, Bacteria - Staphylococcus aureus)
• Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse Elife, 2016-07-21;5(0):. 2016-07-21 [PMID: 27440222] (Bioassay, Human)
• Interaction between Endothelial Protein C Receptor and Intercellular Adhesion Molecule 1 to Mediate Binding of Plasmodium falciparum-Infected Erythrocytes to Endothelial Cells MBio, 2016-07-12;7(4):. 2016-07-12 [PMID: 27406562] (Bioassay, Human)
• WNK1 kinase balances T cell adhesion versus migration in vivo Nat Immunol, 2016-07-11;0(0):. 2016-07-11 [PMID: 27400149] (Bioassay, Human)
• Seung Hee Jung ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion J Immunol, 2016-06-22;0(0):. 2016-06-22 [PMID: 27335501] (Bioassay, Human)
• Yago T, Tsukamoto H, Liu Z, Wang Y, Thompson L, McEver R Multi-Inhibitory Effects of A2A Adenosine Receptor Signaling on Neutrophil Adhesion Under Flow. J Immunol, 2015-09-09;195(8):3880-9. 2015-09-09 [PMID: 26355151] (Bioassay, Human)
• Mukovozov I, Huang Y, Zhang Q, Liu G, Siu A, Sokolskyy Y, Patel S, Hyduk S, Kutryk M, Cybulsky M, Robinson L The Neurorepellent Slit2 Inhibits Postadhesion Stabilization of Monocytes Tethered to Vascular Endothelial Cells. J Immunol, 2015-08-21;195(7):3334-44. 2015-08-21 [PMID: 26297762] (Bioassay, Human)
• Patrussi L, Capitani N, Martini V, Pizzi M, Trimarco V, Frezzato F, Marino F, Semenzato G, Trentin L, Baldari C Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia. Cancer Res, 2015-08-17;75(19):4153-63. 2015-08-17 [PMID: 26282174] (Bioassay, Human)
• Chimen M, McGettrick H, Apta B, Kuravi S, Yates C, Kennedy A, Odedra A, Alassiri M, Harrison M, Martin A, Barone F, Nayar S, Hitchcock J, Cunningham A, Raza K, Filer A, Copland D, Dick A, Robinson J, Kalia N, Walker L, Buckley C, Nash G, Narendran P, Rainger G Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. Nat Med, 2015-04-20;21(5):467-75. 2015-04-20 [PMID: 25894827] (Bioassay, Human)
• Na B, Kim H, Piragyte I, Oh H, Kwon M, Akber U, Lee H, Park D, Song W, Park Z, Im S, Rho M, Hyun Y, Kim M, Jun C TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse. J Cell Biol, 2015-04-13;209(1):143-62. 2015-04-13 [PMID: 25869671] (Adhesion Assay, Human)
• Krishnamurthy V, Sardar M, Ying Y, Song X, Haller C, Dai E, Wang X, Hanjaya-Putra D, Sun L, Morikis V, Simon S, Woods R, Cummings R, Chaikof E Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo. Nat Commun, 2015-03-31;6(0):6387. 2015-03-31 [PMID: 25824568] (Bioassay, Human)
• Morrison A, Yarovinsky T, Young B, Moraes F, Ross T, Ceneri N, Zhang J, Zhuang Z, Sinusas A, Pardi R, Schwartz M, Simons M, Bender J Chemokine-coupled beta2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exp Med, 2014-09-01;211(10):1957-68. 2014-09-01 [PMID: 25180062] (Bioassay)
• Brown W, Khalili J, Rodriguez-Cruz T, Lizee G, McIntyre B B-Raf regulation of integrin alpha4beta1-mediated resistance to shear stress through changes in cell spreading and cytoskeletal association in T cells. J Biol Chem, 2014-06-16;289(33):23141-53. 2014-06-16 [PMID: 24936068] (Bioassay, Human)
• Ong S, Freeley M, Skubis-Zegadlo J, Fazil M, Kelleher D, Fresser F, Baier G, Verma N, Long A Phosphorylation of Rab5a protein by protein kinase C is crucial for T-cell migration. J Biol Chem, 2014-05-28;289(28):19420-34. 2014-05-28 [PMID: 24872409] (Bioassay, Human)
• Halai , Krishma, Whiteford , James, Ma , Bin, Nourshargh , Sussan, Woodfin , Abigail ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo. J Cell Sci, 2013-12-06;127(0):620-9. 2013-12-06 [PMID: 24317296] (Bioassay, Mouse)
• Chimote , Ameet A, Hajdu , Peter, Kucher , Vladimir, Boiko , Nina, Kuras , Zerrin, Szilagyi , Orsolya, Yun , Yeo-Heun, Conforti , Laura Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells. J Immunol, 2013-11-13;191(12):6273-80. 2013-11-13 [PMID: 24227782] (Bioassay, Human)
• Zhang C, Liu J, Jiang X, Haydar N, Zhang C, Shan H, Zhu J Modulation of integrin activation and signaling by alpha1/alpha1&#039;-helix unbending at the junction. J Cell Sci, 2013-10-21;126(0):5735-47. 2013-10-21 [PMID: 24144695] (Flow Cytometry, Human)
• Li N, Mao D, Lu S, Tong C, Zhang Y, Long M Distinct binding affinities of Mac-1 and LFA-1 in neutrophil activation. J Immunol, 2013-03-20;190(8):4371-81. 2013-03-20 [PMID: 23514737] (Bioassay, Human)
• Harker K, Ueno N, Wang T, Bonhomme C, Liu W, Lodoen M Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress. J Leukoc Biol, 2013-03-13;93(5):789-800. 2013-03-13 [PMID: 23485448] (Bioassay, Human)
• Verma N, Dempsey E, Long A, Davies A, Barry S, Fallon P, Volkov Y, Kelleher D Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-beta signaling. J Biol Chem, 2012-06-15;287(32):27204-16. 2012-06-15 [PMID: 22707713] (Bioassay, Human)
• Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation. Eur J Immunol, 2012-08-01;42(8):2142-51. 2012-08-01 [PMID: 22585739] (Bioassay, Human)
• Martinez-Vinambres E, Garcia-Trujillo JA, Rodriguez-Martin E, Villar LM, Coll J, Roldan E CD29 expressed on plasma cells is activated by divalent cations and soluble CD106 contained in the bone marrow plasma: refractory activation is associated with enhanced proliferation and exit of clonal plasma cells to circulation in multiple myeloma patients. Leukemia, 2011-12-02;26(5):1098-105. 2011-12-02 [PMID: 22134715] (Bioassay, Human)
• Shannon-Lowe C, Rowe M Epstein-Barr virus infection of polarized epithelial cells via the basolateral surface by memory B cell-mediated transfer infection. PLoS Pathog., 2011-05-05;7(5):e1001338. 2011-05-05 [PMID: 21573183] (Adhesion Assay, Human)
• Luissint AC, Lutz PG, Calderwood DA, Couraud PO, Bourdoulous S JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. J. Cell Biol., 2008-12-08;183(6):1159-73. 2008-12-08 [PMID: 19064666] (Bioassay, Human)
• Carreno R, Li D, Sen M, Nira I, Yamakawa T, Ma Q, Legge GB A mechanism for antibody-mediated outside-in activation of LFA-1. J. Biol. Chem., 2008-01-16;283(16):10642-8. 2008-01-16 [PMID: 18199751] (Surface Plasmon Resonance, Human)
• Woolf E, Grigorova I, Sagiv A, Grabovsky V, Feigelson SW, Shulman Z, Hartmann T, Sixt M, Cyster JG, Alon R Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat. Immunol., 2007-08-26;8(10):1076-85. 2007-08-26 [PMID: 17721537] (Bioassay, Human)
• Lutz MA, Correll PH Activation of CR3-mediated phagocytosis by MSP requires the RON receptor, tyrosine kinase activity, phosphatidylinositol 3-kinase, and protein kinase C zeta. J. Leukoc. Biol., 2003-06-01;73(6):802-14. 2003-06-01 [PMID: 12773513] (Flow Cytometry, Human)
• Maki W, Morales RE, Carroll VA, Telford WG, Knibbs RN, Stoolman LM, Hwang ST CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells. J. Immunol., 2002-09-01;169(5):2346-53. 2002-09-01 [PMID: 12193700] (Bioassay, Human)

Bioinformatics

• Gene Symbol: ICAM1
• Uniprot:
  • CAA30051()