Recombinant Human FGF-10 Protein

Recombinant Human FGF-10 (Catalog # 345-FG) stimulates cell proliferation of the 4MBr‑5 rhesus monkey epithelial cell line. The ED50 for this effect is 20‑100 ng/mL.

1 μg/lane of Recombinant Human FGF-10 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 21 kDa.

Adult stem cells isolated from human lung biopsy tissue were embedded in Cultrex UltiMatrix RGF Basement Membrane Extract (BME001-05) and cultured for 20-60 days in lung organoid expansion medium, which includes Recombinant Human FGF-10 (Catalog # 345-FG), Recombinant Human KGF/FGF-7 (251-KG), Recombinant Human Noggin (6057-NG), and Recombinant Human R-Spondin 1 (4645-RS), along with the other reagents listed in the lung organoid expansion medium recipe in the lung organoid culture protocol. Lung organoids were able to differentiate and exhibit markers for various cell types of the lung. Lung organoids were stained with (A) a Rabbit Anti-Human Cytokeratin 5 (KRT5) Monoclonal Antibody (Novus Biologicals, Catalog # NB110-56916; green) and a Goat Anti-Human p63/TP73L Polyclonal Antibody (AF1916; red) to visualize basal cells, (B) a Hamster Anti-Mouse Podoplanin (PDPN) Monoclonal Antibody (Novus Biologicals, Catalog # NB600-1015; green) to visualize alveolar type I cells and a Goat Anti-Human p63/TP73L Polyclonal Antibody (AF1916; red) to visualize basal cells, and (C, D) a Mouse Anti-MUC5AC Monoclonal Antibody (Novus Biologicals, Catalog # NBP2-15196; green) to visualize Goblet cells and a Mouse Anti-Human/Mouse/Rat SOX2 Monoclonal Antibody (MAB2018; red). All samples were counterstained with DAPI (5748; blue).

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human FGF-10 Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using 4MBr‑5 rhesus monkey epithelial cells. Rubin, J.S. et al. (1989) Proc. Natl. Acad. Sci. USA 86:802. The ED₅₀ for this effect is 20-100 ng/mL.
• Source: E. coli-derived human FGF-10 protein
  Cys37-Ser208 & Gly41-Ser208
• Accession #: O15520
• N-terminal Sequence: Cys37 & Gly41
• Protein/Peptide Type: Recombinant Proteins
• Gene: FGF10
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 19.5 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 19-22 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in MOPS, Na₂SO₄, EDTA and DTT with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human FGF-10 Protein

• FGF10
• FGF-10
• fibroblast growth factor 10
• Keratinocyte growth factor 2
• KGF2
• KGF-2
• produced by fibroblasts of urinary bladder lamina propria

Background

The Fibroblast Growth Factors (FGFs) are heparin binding glycoproteins that exert a variety of biological activities toward cells of mesenchymal, neuronal, and epithelial origin. FGF-10 belongs to the subgroup of FGFs that also includes FGF-3, -7, and -22 (1). Mature human FGF-10 is an approximately 20 kDa protein that contains a serine-rich region near its N-terminus (2, 3). It shares 93% and 96% amino acid sequence identity with mouse and rat FGF-10, respectively. FGF-10 is secreted by mesenchymal cells and associates with extracellular FGF-BP (1, 4). It preferentially binds and activates epithelial cell FGF R2 (IIIb) and interacts more weakly with FGF R1 (IIIb) (5). The mitogenic and chemotactic properties of FGF-10 are critical in many tissues during embryogenesis. This includes limb bud initiation (6), palate development (7), branching morphogenesis and directional outgrowth of lung buds (8, 9), formation of the otic vesicle and chochlea (10), adipogenesis (11), and the development of prostate, mammary, lacrimal, and submandibular salivary glands (12 - 15). FGF R2 (IIIb) signaling in these responsive tissues is similarly important during embryogenesis (7, 10, 13 ‑ 15). The expression and function of FGF-10 are negatively regulated by Shh and BMP-4 in the developing lung (8, 9). Overlapping expression patterns and activities with FGF-3, -7,  and -8 suggest at least a partial redundancy in FGF‑10 biology (7, 10, 14, 15). FGF-10 induced signaling through FGF R2 (IIIb) also contributes to the progression of pancreatic cancer (16).

1. Beenken, A. and M. Mohammadi (2009) Nat. Rev. Drug Discov. 8:235.
2. Igarashi, M. et al. (1998) J. Biol. Chem. 273:13230.
3. Emoto, H. et al. (1997) J. Biol. Chem. 272:23191.
4. Beer, H.-D. et al. (2005) Oncogene 24:5269.
5. Zhang, X. et al. (2006) J. Biol. Chem. 281:15694.
6. Min, H. et al. (1998) Genes Dev. 12:3156.
7. Rice, R. et al. (2004) J. Clin. Invest. 113:1692.
8. Bellusci, S. et al. (1997) Development 124:4867.
9. Weaver, M. et al. (2000) Development 127:2695.
10. Pirvola, U. et al. (2000) J. Neurosci. 20:6125.
11. Sakaue, H. et al. (2002) Genes Dev. 16:908.
12. Donjacour, A.A. et al. (2003) Dev. Biol. 261:39.
13. Mailleux, A.A. et al. (2002) Development 129:53.
14. Makarenkova, H.P. et al. (2000) Development 127:2563.
15. Jaskoll, T. et al. (2005) BMC Dev. Biol. 5:11.
16. Nomura, S. et al. (2008) Br. J. Cancer 99:305.

Publications for FGF-10 (345-FG)(110)

Publications using 345-FG

• Han, HJ;Kim, H; 3D alveolar organoid drug screening model for targeting TGF-?1 in pulmonary fibrosis Biochemistry and biophysics reports 2025-09-01 [PMID: 40832470] (Bioassay, Human)
• Wang, W;Lian, Y;Li, J;Wu, Y;Li, M;Wu, Y;Xu, R;Zhao, X;Kang, J;Guo, X; Zbtb16 determines the fate plasticity of cardiovascular progenitors through IGF2BP3-mediated mRNA stabilization Cell reports 2025-08-07 [PMID: 40779394] (Bioassay, Mouse)
• Zhang, R;Yang, Y;Li, R;Ma, Y;Ma, S;Chen, X;Li, B;Li, B;Qi, X;Ha, C; Construction organoid model of ovarian endometriosis and the function of estrogen and progesterone in the model Scientific reports 2025-02-24 [PMID: 39994247] (Bioassay, Human)
• Goswami, Y;Baghel, A;Sharma, G;Sharma, PK;Biswas, S;Yadav, R;Garg, PK;Shalimar, ;Tandon, R; Liver Organoids From Hepatocytes of Healthy Humans and Non-alcoholic Fatty Liver Disease (NAFLD) Patients Display Multilineage Architecture and can be Used to Develop an In Vitro Model of Steatohepatitis Journal of clinical and experimental hepatology 2024-12-03 [PMID: 39872219] (Bioassay, Human)
• Shan, H;Chen, M;Zhao, S;Wei, X;Zheng, M;Li, Y;Lin, Q;Jiang, Z;Chen, Z;Fei, C;Li, Z;Chen, Z;Chen, X; Acoustic virtual 3D scaffold for direct-interacting tumor organoid-immune cell coculture systems Science advances 2024-11-22 [PMID: 39576870] (Bioassay, Human)
• Peak, KE;Rajaguru, P;Khan, A;Gleghorn, JP;Obaid, G;Ferruzzi, J;Varner, VD; Photo-induced changes in tissue stiffness alter epithelial budding morphogenesis in the embryonic lung bioRxiv : the preprint server for biology 2024-08-26 [PMID: 39229009] (Bioassay, Chicken)
• Chen, Y;Mu, W;Wu, Y;Xu, J;Li, X;Hu, H;Wang, S;Wang, D;Hui, B;Wang, L;Dong, Y;Chen, W; Optogenetically modified human embryonic stem cell-derived otic neurons establish functional synaptic connection with cochlear nuclei Journal of tissue engineering 2024-07-31 [PMID: 39092452] (Bioassay, Human)
• Zhang, R;Chen, Y;Feng, Z;Cai, B;Cheng, Y;Du, Y;Ou, S;Chen, H;Pan, M;Liu, H;Pei, D;Cao, S; Reprogramming human urine cells into intestinal organoids with long-term expansion ability and barrier function Heliyon 2024-07-15 [PMID: 39040281] (Bioassay, Human)
• Donahue, KL;Watkoske, HR;Kadiyala, P;Du, W;Brown, K;Scales, MK;Elhossiny, AM;Espinoza, CE;Lasse Opsahl, EL;Griffith, BD;Wen, Y;Sun, L;Velez-Delgado, A;Renollet, NM;Morales, J;Nedzesky, NM;Baliira, RK;Menjivar, RE;Medina-Cabrera, PI;Rao, A;Allen, B;Shi, J;Frankel, TL;Carpenter, ES;Bednar, F;Zhang, Y;Pasca di Magliano, M; Oncogenic KRAS-dependent stromal interleukin-33 directs the pancreatic microenvironment to promote tumor growth Cancer discovery 2024-07-03 [PMID: 38958646] (Bioassay, Human)
• Schäfer, TE;Knol, LI;Haas, FV;Hartley, A;Pernickel, SCS;Jády, A;Finkbeiner, MSC;Achberger, J;Arelaki, S;Modic, Ž;Schröer, K;Zhang, W;Schmidt, B;Schuster, P;Haferkamp, S;Doerner, J;Gebauer, F;Ackermann, M;Kvasnicka, HM;Kulkarni, A;Bots, STF;Kemp, V;Hawinkels, LJAC;Poetsch, AR;Hoeben, RC;Ehrhardt, A;Marchini, A;Ungerechts, G;Ball, CR;Engeland, CE; Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures EBioMedicine 2024-06-27 [PMID: 38941955] (Bioassay, Human)
• Nipper, M;Xu, Y;Liu, J;Yin, X;Liu, Z;Ye, Z;Zhang, J;Chen, Y;Wang, P; TGF? and Hippo Signaling Pathways Coordinate to Promote Acinar to Ductal Metaplasia in Human Pancreas Cells 2024-01-18 [PMID: 38247878] (Cell Culture, Human)
• Li, C;Liu, Z;Anderson, J;Liu, Z;Tang, L;Li, Y;Peng, N;Chen, J;Liu, X;Fu, L;Townes, TM;Rowe, SM;Bedwell, DM;Guimbellot, J;Zhao, R; Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells PloS one 2023-11-29 [PMID: 38019847] (Bioassay, Human)
• Yang, Y;McCullough, CG;Seninge, L;Guo, L;Kwon, WJ;Zhang, Y;Li, NY;Gaddam, S;Pan, C;Zhen, H;Torkelson, J;Glass, IA;Birth Defects Research Laboratory, ;Charville, G;Que, J;Stuart, J;Ding, H;Oro, A; A Spatiotemporal and Machine-Learning Platform Accelerates the Manufacturing of hPSC-derived Esophageal Mucosa bioRxiv : the preprint server for biology 2023-10-26 [PMID: 37961271] (Bioassay, Human)
• Chen, HJ;Gardner, EE;Shah, Y;Zhang, K;Thakur, A;Zhang, C;Elemento, O;Varmus, H; FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS bioRxiv : the preprint server for biology 2023-10-09 [PMID: 37873210] (Bioassay, Human)
• Ito, I;Yousef, AMG;Chowdhury, S;Dickson, PN;Naini, ZA;White, MG;Fleten, KG;Flatmark, K;Fournier, KF;Fowlkes, NW;Shen, JP; Intraperitoneal paclitaxel is a safe and effective therapeutic strategy for treating mucinous appendiceal adenocarcinoma Cancer research 2023-07-11 [PMID: 37433032] (Bioassay, Human)
• Alber, AB;Marquez, HA;Ma, L;Kwong, G;Thapa, BR;Villacorta-Martin, C;Lindstrom-Vautrin, J;Bawa, P;Wang, F;Luo, Y;Ikonomou, L;Shi, W;Kotton, DN; Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme Nature communications 2023-06-13 [PMID: 37311756] (Bioassay, Transgenic Mouse)
• Matkovic Leko, I;Schneider, RT;Thimraj, TA;Schrode, N;Beitler, D;Liu, HY;Beaumont, K;Chen, YW;Snoeck, HW; A distal lung organoid model to study interstitial lung disease, viral infection and human lung development Nature protocols 2023-05-10 [PMID: 37165073] (Bioassay, Human)
• IM Leko, N Schrode, J Torres, M Pezet, TA Thimraj, KG Beaumont, HW Snoeck Generation and expansion of transitional lung organoids from human pluripotent stem cells bioRxiv : the preprint server for biology, 2023-02-01;0(0):. 2023-02-01 [PMID: 36778291] (Bioassay, Human)
• A Floerching, JE Klein, MSC Finkbeiner, TE Schäfer, G Fuchs, J Doerner, H Zirngibl, M Ackermann, HM Kvasnicka, KA Chester, D Jäger, CR Ball, G Ungerechts, CE Engeland A vector-encoded bispecific killer engager to harness virus-activated NK cells as anti-tumor effectors Cell Death & Disease, 2023-02-10;14(2):104. 2023-02-10 [PMID: 36765035] (Bioassay, Human)
• J Tian, JH Chen, SX Chao, K Pelka, M Giannakis, J Hess, K Burke, V Jorgji, P Sindurakar, J Braverman, A Mehta, T Oka, M Huang, D Lieb, M Spurrell, JN Allen, TA Abrams, JW Clark, AC Enzinger, PC Enzinger, SJ Klempner, NJ McCleary, JA Meyerhardt, DP Ryan, MB Yurgelun, K Kanter, EE Van Sevent, I Baiev, G Chi, J Jarnagin, WB Bradford, E Wong, AG Michel, IJ Fetter, G Siravegna, AJ Gemma, A Sharpe, S Demehri, R Leary, CD Campbell, O Yilmaz, GA Getz, AR Parikh, N Hacohen, RB Corcoran Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial Nature Medicine, 2023-01-26;0(0):. 2023-01-26 [PMID: 36702949] (Bioassay, Human)
• G Parthasara, MB Pattison, CC Midkiff The FGF/FGFR system in the microglial neuroinflammation with Borrelia burgdorferi: likely intersectionality with other neurological conditions Journal of Neuroinflammation, 2023-01-17;20(1):10. 2023-01-17 [PMID: 36650549] (Bioassay, Macaca mulatta (Rhesus Macaque))
• Y Sun, OY Revach, S Anderson, EA Kessler, CH Wolfe, A Jenney, CE Mills, EJ Robitschek, TGR Davis, S Kim, A Fu, X Ma, J Gwee, P Tiwari, PP Du, P Sindurakar, J Tian, A Mehta, AM Schneider, K Yizhak, M Sade-Feldm, T LaSalle, T Sharova, H Xie, S Liu, WA Michaud, R Saad-Beret, KB Yates, A Iracheta-V, JKE Spetz, X Qin, KA Sarosiek, G Zhang, JW Kim, MY Su, AM Cicerchia, MQ Rasmussen, SJ Klempner, D Juric, SI Pai, DM Miller, A Giobbie-Hu, JH Chen, K Pelka, DT Frederick, S Stinson, E Ivanova, AR Aref, CP Paweletz, DA Barbie, DR Sen, DE Fisher, RB Corcoran, N Hacohen, PK Sorger, KT Flaherty, GM Boland, RT Manguso, RW Jenkins Targeting TBK1 to overcome resistance to cancer immunotherapy Nature, 2023-01-12;0(0):. 2023-01-12 [PMID: 36634707] (Bioassay, Human)
• S Raad, A David, M Sagniez, B Paré, Z Orfi, NA Dumont, MA Smith, C Faure iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage Disease Models & Mechanisms, 2022-11-28;0(0):. 2022-11-28 [PMID: 36317486] (Bioassay, Human)
• H Wang, B Keepers, Y Qian, Y Xie, M Colon, J Liu, L Qian Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes Cell Stem Cell, 2022-10-06;29(10):1491-1504.e9. 2022-10-06 [PMID: 36206732] (Bioassay, Mouse)
• Y Han, L Tan, T Zhou, L Yang, L Carrau, LA Lacko, M Saeed, J Zhu, Z Zhao, BE Nilsson-Pa, FT Lira Neto, C Cahir, AM Giani, JC Chai, Y Li, X Dong, D Moroziewic, NYSCF Glob, D Paull, T Zhang, S Koo, C Tan, R Danziger, Q Ba, L Feng, Z Chen, A Zhong, GJ Wise, JZ Xiang, H Wang, RE Schwartz, BR tenOever, SA Noggle, CM Rice, Q Qi, T Evans, S Chen A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants Cell Stem Cell, 2022-10-06;29(10):1475-1490.e6. 2022-10-06 [PMID: 36206731] (Bioassay, Human)
• T Jiang, W Hu, S Zhang, C Ren, S Lin, Z Zhou, H Wu, J Yin, L Tan Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis Respiratory Research, 2022-10-01;23(1):269. 2022-10-01 [PMID: 36183124] (Cell Culture, Human)
• MC Jaboreck, JL Lühmann, M Mielenz, F Stanke, G Göhring, U Martin, R Olmer, S Merkert Generation of two TMEM16A knockout iPSC clones each from a healthy human iPSC line, from a Cystic Fibrosis patient specific line with p.Phe508del mutation and from the gene corrected iPSC line Stem Cell Research, 2022-09-14;64(0):102918. 2022-09-14 [PMID: 36162332] (Bioassay, Human)
• V Lungova, K Wendt, SL Thibeault Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling Oncogene, 2022-08-23;0(0):. 2022-08-23 [PMID: 35770504] (Bioassay, Human)
• Marie O. Pohl, Laura Martin-Sancho, Ranjala Ratnayake, Kris M. White, Laura Riva, Qi-Yin Chen et al. Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity ACS Infectious Diseases 2022-07-08 [PMID: 35766385] (Bioassay, Human)
• A Chansaenro, C Adine, S Charoenlap, S Roytrakul, L Sariya, T Osathanon, S Rungarunle, G Urkasemsin, R Chaisupara, S Yodmuang, GR Souza, JN Ferreira Magnetic bioassembly platforms towards the generation of extracellular vesicles from human salivary gland functional organoids for epithelial repair Bioactive materials, 2022-02-16;18(0):151-163. 2022-02-16 [PMID: 35387159] (Bioassay, Human)
• S Imamura, K Yoshimoto, S Terada, K Takamuro, KI Kamei In vitro culture at 39��C during hepatic maturation of human ES cells facilitates hepatocyte-like cell functions Scientific Reports, 2022-03-25;12(1):5155. 2022-03-25 [PMID: 35338220] (Bioassay, Human)
• AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells Cell Stem Cell, 2021-12-01;0(0):. 2021-12-01 [PMID: 34856121] (Bioassay, Human)
• L Johnson Ch, H Lahlou, C Steinacher, S Assou, Y Messat, J Dudás, A Edge, B Crespo, M Crosier, C Sergi, A Schrott-Fi, A Zine Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs International Journal of Molecular Sciences, 2021-10-07;22(19):. 2021-10-07 [PMID: 34639189] (Bioassay, Human)
• K Gkatzis, P Panza, S Peruzzo, DY Stainier Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures Elife, 2021-09-29;10(0):. 2021-09-29 [PMID: 34586063] (Bioassay, Mouse)
• Y Aghazadeh, F Poon, F Sarangi, FTM Wong, ST Khan, X Sun, R Hatkar, BJ Cox, SS Nunes, MC Nostro Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models Cell Stem Cell, 2021-09-03;0(0):. 2021-09-03 [PMID: 34480863] (Bioassay, Human)
• MO Lee, SG Lee, CR Jung, YS Son, JW Ryu, KB Jung, JH Ahn, JH Oh, HA Lee, JH Lim, J Kim, I Jang, J Choi, J Jung, K Park, B Lee, DS Kim, MY Son, HS Cho Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells Nature Communications, 2021-07-23;12(1):4492. 2021-07-23 [PMID: 34301945] (Bioassay, Human)
• AL Rodrigues, HY Liu, YW Chen, M Porotto, A Moscona, HW Snoeck The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D Nature Protocols, 2021-03-01;0(0):. 2021-03-01 [PMID: 33649566] (Bioassay, Human)
• H Tomita, K Tanaka, A Hirata, H Okada, H Imai, Y Shirakami, K Ohnishi, S Sugie, H Aoki, Y Hatano, K Noguchi, T Kanayama, A Niwa, N Suzui, T Miyazaki, T Tanaka, H Akiyama, M Shimizu, K Yoshida, A Hara Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas Cell Reports, 2021-02-23;34(8):108772. 2021-02-23 [PMID: 33626352] (Human)
• L Cui, J Zheng, Q Zhao, JR Chen, H Liu, G Peng, Y Wu, C Chen, Q He, H Shi, S Yin, RA Friedman, Y Chen, MX Guan Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss JCI Insight, 2020-12-03;5(23):. 2020-12-03 [PMID: 33268592] (Bioassay, Human)
• FJ Hawkins, S Suzuki, ML Beermann, C Barillà, R Wang, C Villacorta, A Berical, JC Jean, J Le Suer, T Matte, C Simone-Roa, Y Tang, TM Schlaeger, AM Crane, N Matthias, SXL Huang, SH Randell, J Wu, JR Spence, G Carraro, BR Stripp, A Rab, EJ Sorsher, A Horani, SL Brody, BR Davis, DN Kotton Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells Cell Stem Cell, 2020-10-23;0(0):. 2020-10-23 [PMID: 33098807] (Bioassay, Human)
• J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Lindstrom-, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response Cell Stem Cell, 2020-09-18;0(0):. 2020-09-18 [PMID: 32979316] (Bioassay, Human)
• MT Hoffman, SB Kemp, DJ Salas-Esca, Y Zhang, NG Steele, S The, D Long, S Benitz, W Yan, RF Margolskee, F Bednar, M Pasca di M, HJ Wen, HC Crawford The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice Cell Mol Gastroenterol Hepatol, 2020-08-31;0(0):. 2020-08-31 [PMID: 32882403] (Cell Culture, Mouse)
• F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq, 2020-09-15;0(0):. 2020-09-15 [PMID: 32839764] (Bioassay, Human)
• J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response bioRxiv, 2020-08-06;0(0):. 2020-08-06 [PMID: 32637964] (Bioassay, Human)
• L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020;27(1):125-136.e7. 2020 [PMID: 32579880] (Bioassay, Human)
• L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020-06-19;27(1):125-136.e7. 2020-06-19 [PMID: 32579880] (Bioassay, Human)
• N Chanthra, T Abe, M Miyamoto, K Sekiguchi, C Kwon, Y Hanazono, H Uosaki A Novel Fluorescent Reporter System Identifies Laminin-511/521 as Potent Regulators of Cardiomyocyte Maturation Sci Rep, 2020-03-06;10(1):4249. 2020-03-06 [PMID: 32144297] (Bioassay, Human)
• R Matsumoto, H Suga, T Aoi, H Bando, H Fukuoka, G Iguchi, S Narumi, T Hasegawa, K Muguruma, W Ogawa, Y Takahashi Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells J. Clin. Invest., 2020-02-03;130(2):641-654. 2020-02-03 [PMID: 31845906] (Bioassay, Human)
• A Sahabian, M Sgodda, O Naujok, R Dettmer, J Dahlmann, F Manstein, T Cantz, R Zweigerdt, U Martin, R Olmer Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential Cells, 2019-12-04;8(12):. 2019-12-04 [PMID: 31817235] (Bioassay, Human)
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• Retinal Proteoglycans Act as Cellular Receptors for Basement Membrane Assembly to Control Astrocyte Migration and Angiogenesis Cell Rep, 2016-11-08;17(7):1832-1844. 2016-11-08 [PMID: 27829154] (Binding Assay, Mouse)
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• Maya Valeska Gozali Photodynamic therapy inhibit Fibroblast Growth Factor-10 induced keratinocyte differentiation and proliferation through ROS in Fibroblast Growth Factor Receptor-2b pathway Sci Rep, 2016-06-07;6(0):27402. 2016-06-07 [PMID: 27273653] (Bioassay, Human)
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• Comps-Agrar L, Dunshee D, Eaton D, Sonoda J Unliganded fibroblast growth factor receptor 1 forms density-independent dimers. J Biol Chem, 2015-08-13;290(40):24166-77. 2015-08-13 [PMID: 26272615] (Bioassay, Human)
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• Pethe , Prasad, Nagvenkar , Punam, Bhartiya , Deepa Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro. BMC Cell Biol, 2014-05-24;15(0):18. 2014-05-24 [PMID: 24885493] (Bioassay, Human)
• Kanehira M, Kikuchi T, Santoso A, Tode N, Hirano T, Ohkouchi S, Tamada T, Sugiura H, Harigae H, Ichinose M Human marrow stromal cells downsize the stem cell fraction of lung cancers by fibroblast growth factor 10. Mol Cell Biol, 2014-05-27;34(15):2848-56. 2014-05-27 [PMID: 24865969] (Bioassay, Human)
• Ohnuma , Kiyoshi, Fujiki , Ayaka, Yanagihara , Kana, Tachikawa , Saoko, Hayashi , Yohei, Ito , Yuzuru, Onuma , Yasuko, Chan , Techuan, Michiue , Tatsuo, Furue , Miho K, Asashima , Makoto Enzyme-free passage of human pluripotent stem cells by controlling divalent cations. Sci Rep, 2014-04-11;4(0):4646. 2014-04-11 [PMID: 24721898] (Bioassay, Human)
• Takeuchi , Hiroki, Nakatsuji , Norio, Suemori , Hirofumi Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture. Sci Rep, 2014-03-27;4(0):4488. 2014-03-27 [PMID: 24671046] (Bioassay, Human)
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• Huang , Sarah X, Islam , Mohammad, O'Neill , John, Hu , Zheng, Yang , Yong-Gua, Chen , Ya-Wen, Mumau , Melanie, Green , Michael, Vunjak-Novakovic , Gordana, Bhattacharya , Jahar, Snoeck , Hans-Wil Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol, 2013-12-01;32(1):84-91. 2013-12-01 [PMID: 24291815] (Bioassay, Human)
• Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann J, Miyazaki S, Miyazaki J, Szot G, Bottino R, Kim S Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife, 2013-11-19;2(0):e00940. 2013-11-19 [PMID: 24252877] (Bioassay, Human)
• Weedon M, Cebola I, Patch A, Flanagan S, De Franco E, Caswell R, Rodriguez-Segui S, Shaw-Smith C, Cho C, Lango Allen H, Houghton J, Roth C, Chen R, Hussain K, Marsh P, Vallier L, Murray A, Ellard S, Ferrer J, Hattersley A Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. Nat Genet, 2013-11-10;46(1):61-4. 2013-11-10 [PMID: 24212882] (Bioassay, Human)
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• Patel N, Sharpe PT, Miletich I Coordination of epithelial branching and salivary gland lumen formation by Wnt and FGF signals. Dev. Biol., 2011-07-23;358(1):156-67. 2011-07-23 [PMID: 21806977] (Bioassay, Mouse)
• Tomlinson DC, Knowles MA Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am. J. Pathol., 2010-10-01;177(5):2379-86. 2010-10-01 [PMID: 20889570] (Bioassay, Human)
• Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell, 2009-04-03;4(4):348-58. 2009-04-03 [PMID: 19341624] (Bioassay, Human, Mouse)
• Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, Suzuki H, Aizawa S, Arakaki M, Yuasa K, Oka K, Chai Y, Nonaka K, Fukumoto S Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J. Biol. Chem., 2008-06-17;283(34):23139-49. 2008-06-17 [PMID: 18559345] (Bioassay, Mouse)
• Patel VN, Likar KM, Zisman-Rozen S, Cowherd SN, Lassiter KS, Sher I, Yates EA, Turnbull JE, Ron D, Hoffman MP Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. J. Biol. Chem., 2008-01-28;283(14):9308-17. 2008-01-28 [PMID: 18230614] (Bioassay, Mouse)
• Cho YM, Lim JM, Yoo DH, Kim JH, Chung SS, Park SG, Kim TH, Oh SK, Choi YM, Moon SY, Park KS, Lee HK Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells. Biochem. Biophys. Res. Commun., 2007-12-04;366(1):129-34. 2007-12-04 [PMID: 18060872] (Bioassay, Human)
• Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development, 2007-10-24;134(23):4177-86. 2007-10-24 [PMID: 17959718] (Bioassay, Mouse)
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Bioinformatics

• Gene Symbol: FGF10
• Uniprot:
  • O15520()