Recombinant Human FGF-10 Protein, CF

Recombinant Human FGF-10 (Catalog # 345-FG/CF) stimulates cell proliferation of the 4MBr‑5 rhesus monkey epithelial cell line. The ED50 for this effect is 20‑100 ng/mL.

1 μg/lane of Recombinant Human FGF-10 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 21 kDa.

Adult stem cells isolated from human lung biopsy tissue were embedded in Cultrex UltiMatrix RGF Basement Membrane Extract (BME001-05) and cultured for 20-60 days in lung organoid expansion medium, which includes Recombinant Human FGF-10 (Catalog # 345-FG/CF), Recombinant Human KGF/FGF-7 (251-KG), Recombinant Human Noggin (6057-NG), and Recombinant Human R-Spondin 1 (4645-RS), along with the other reagents listed in the lung organoid expansion medium recipe in the lung organoid culture protocol. Lung organoids were able to differentiate and exhibit markers for various cell types of the lung. Lung organoids were stained with (A) a Rabbit Anti-Human Cytokeratin 5 (KRT5) Monoclonal Antibody (Novus Biologicals, Catalog # NB110-56916; green) and a Goat Anti-Human p63/TP73L Polyclonal Antibody (AF1916; red) to visualize basal cells, (B) a Hamster Anti-Mouse Podoplanin (PDPN) Monoclonal Antibody (Novus Biologicals, Catalog # NB600-1015; green) to visualize alveolar type I cells and a Goat Anti-Human p63/TP73L Polyclonal Antibody (AF1916; red) to visualize basal cells, and (C, D) a Mouse Anti-MUC5AC Monoclonal Antibody (Novus Biologicals, Catalog # NBP2-15196; green) to visualize Goblet cells and a Mouse Anti-Human/Mouse/Rat SOX2 Monoclonal Antibody (MAB2018; red). All samples were counterstained with DAPI (5748; blue).

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human FGF-10 Protein, CF Summary

• Additional Information: Earn double rewards for reviews
• Details of Functionality: Measured in a cell proliferation assay using 4MBr‑5 rhesus monkey epithelial cells. Rubin, J.S. et al. (1989) Proc. Natl. Acad. Sci. USA 86:802. The ED₅₀ for this effect is 20-100 ng/mL.
• Source: E. coli-derived human FGF-10 protein
  Cys37-Ser208 & Gly41-Ser208
• Accession #: O15520
• N-terminal Sequence: Cys37 & Gly41
• Protein/Peptide Type: Recombinant Proteins
• Gene: FGF10
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 19.5 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 19-22 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in MOPS, Na₂SO₄, EDTA and DTT.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human FGF-10 Protein, CF

• FGF10
• FGF-10
• fibroblast growth factor 10
• Keratinocyte growth factor 2
• KGF2
• KGF-2
• produced by fibroblasts of urinary bladder lamina propria

Background

The Fibroblast Growth Factors (FGFs) are heparin binding glycoproteins that exert a variety of biological activities toward cells of mesenchymal, neuronal, and epithelial origin. FGF-10 belongs to the subgroup of FGFs that also includes FGF-3, -7, and -22 (1). Mature human FGF-10 is an approximately 20 kDa protein that contains a serine-rich region near its N-terminus (2, 3). It shares 93% and 96% amino acid sequence identity with mouse and rat FGF-10, respectively. FGF-10 is secreted by mesenchymal cells and associates with extracellular FGF-BP (1, 4). It preferentially binds and activates epithelial cell FGF R2 (IIIb) and interacts more weakly with FGF R1 (IIIb) (5). The mitogenic and chemotactic properties of FGF-10 are critical in many tissues during embryogenesis. This includes limb bud initiation (6), palate development (7), branching morphogenesis and directional outgrowth of lung buds (8, 9), formation of the otic vesicle and chochlea (10), adipogenesis (11), and the development of prostate, mammary, lacrimal, and submandibular salivary glands (12 - 15). FGF R2 (IIIb) signaling in these responsive tissues is similarly important during embryogenesis (7, 10, 13 ‑ 15). The expression and function of FGF-10 are negatively regulated by Shh and BMP-4 in the developing lung (8, 9). Overlapping expression patterns and activities with FGF-3, -7,  and -8 suggest at least a partial redundancy in FGF‑10 biology (7, 10, 14, 15). FGF-10 induced signaling through FGF R2 (IIIb) also contributes to the progression of pancreatic cancer (16).

1. Beenken, A. and M. Mohammadi (2009) Nat. Rev. Drug Discov. 8:235.
2. Igarashi, M. et al. (1998) J. Biol. Chem. 273:13230.
3. Emoto, H. et al. (1997) J. Biol. Chem. 272:23191.
4. Beer, H.-D. et al. (2005) Oncogene 24:5269.
5. Zhang, X. et al. (2006) J. Biol. Chem. 281:15694.
6. Min, H. et al. (1998) Genes Dev. 12:3156.
7. Rice, R. et al. (2004) J. Clin. Invest. 113:1692.
8. Bellusci, S. et al. (1997) Development 124:4867.
9. Weaver, M. et al. (2000) Development 127:2695.
10. Pirvola, U. et al. (2000) J. Neurosci. 20:6125.
11. Sakaue, H. et al. (2002) Genes Dev. 16:908.
12. Donjacour, A.A. et al. (2003) Dev. Biol. 261:39.
13. Mailleux, A.A. et al. (2002) Development 129:53.
14. Makarenkova, H.P. et al. (2000) Development 127:2563.
15. Jaskoll, T. et al. (2005) BMC Dev. Biol. 5:11.
16. Nomura, S. et al. (2008) Br. J. Cancer 99:305.

Publications for FGF-10 (345-FG/CF)(91)

Publications using 345-FG/CF

• IM Leko, N Schrode, J Torres, M Pezet, TA Thimraj, KG Beaumont, HW Snoeck Generation and expansion of transitional lung organoids from human pluripotent stem cells bioRxiv : the preprint server for biology, 2023-02-01;0(0):. 2023-02-01 [PMID: 36778291] (Bioassay, Human)
• A Floerching, JE Klein, MSC Finkbeiner, TE Schäfer, G Fuchs, J Doerner, H Zirngibl, M Ackermann, HM Kvasnicka, KA Chester, D Jäger, CR Ball, G Ungerechts, CE Engeland A vector-encoded bispecific killer engager to harness virus-activated NK cells as anti-tumor effectors Cell Death & Disease, 2023-02-10;14(2):104. 2023-02-10 [PMID: 36765035] (Bioassay, Human)
• J Tian, JH Chen, SX Chao, K Pelka, M Giannakis, J Hess, K Burke, V Jorgji, P Sindurakar, J Braverman, A Mehta, T Oka, M Huang, D Lieb, M Spurrell, JN Allen, TA Abrams, JW Clark, AC Enzinger, PC Enzinger, SJ Klempner, NJ McCleary, JA Meyerhardt, DP Ryan, MB Yurgelun, K Kanter, EE Van Sevent, I Baiev, G Chi, J Jarnagin, WB Bradford, E Wong, AG Michel, IJ Fetter, G Siravegna, AJ Gemma, A Sharpe, S Demehri, R Leary, CD Campbell, O Yilmaz, GA Getz, AR Parikh, N Hacohen, RB Corcoran Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial Nature Medicine, 2023-01-26;0(0):. 2023-01-26 [PMID: 36702949] (Bioassay, Human)
• G Parthasara, MB Pattison, CC Midkiff The FGF/FGFR system in the microglial neuroinflammation with Borrelia burgdorferi: likely intersectionality with other neurological conditions Journal of Neuroinflammation, 2023-01-17;20(1):10. 2023-01-17 [PMID: 36650549] (Bioassay, Macaca mulatta (Rhesus Macaque))
• Y Sun, OY Revach, S Anderson, EA Kessler, CH Wolfe, A Jenney, CE Mills, EJ Robitschek, TGR Davis, S Kim, A Fu, X Ma, J Gwee, P Tiwari, PP Du, P Sindurakar, J Tian, A Mehta, AM Schneider, K Yizhak, M Sade-Feldm, T LaSalle, T Sharova, H Xie, S Liu, WA Michaud, R Saad-Beret, KB Yates, A Iracheta-V, JKE Spetz, X Qin, KA Sarosiek, G Zhang, JW Kim, MY Su, AM Cicerchia, MQ Rasmussen, SJ Klempner, D Juric, SI Pai, DM Miller, A Giobbie-Hu, JH Chen, K Pelka, DT Frederick, S Stinson, E Ivanova, AR Aref, CP Paweletz, DA Barbie, DR Sen, DE Fisher, RB Corcoran, N Hacohen, PK Sorger, KT Flaherty, GM Boland, RT Manguso, RW Jenkins Targeting TBK1 to overcome resistance to cancer immunotherapy Nature, 2023-01-12;0(0):. 2023-01-12 [PMID: 36634707] (Bioassay, Human)
• S Raad, A David, M Sagniez, B Paré, Z Orfi, NA Dumont, MA Smith, C Faure iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage Disease Models & Mechanisms, 2022-11-28;0(0):. 2022-11-28 [PMID: 36317486] (Bioassay, Human)
• H Wang, B Keepers, Y Qian, Y Xie, M Colon, J Liu, L Qian Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes Cell Stem Cell, 2022-10-06;29(10):1491-1504.e9. 2022-10-06 [PMID: 36206732] (Bioassay, Mouse)
• Y Han, L Tan, T Zhou, L Yang, L Carrau, LA Lacko, M Saeed, J Zhu, Z Zhao, BE Nilsson-Pa, FT Lira Neto, C Cahir, AM Giani, JC Chai, Y Li, X Dong, D Moroziewic, NYSCF Glob, D Paull, T Zhang, S Koo, C Tan, R Danziger, Q Ba, L Feng, Z Chen, A Zhong, GJ Wise, JZ Xiang, H Wang, RE Schwartz, BR tenOever, SA Noggle, CM Rice, Q Qi, T Evans, S Chen A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants Cell Stem Cell, 2022-10-06;29(10):1475-1490.e6. 2022-10-06 [PMID: 36206731] (Bioassay, Human)
• T Jiang, W Hu, S Zhang, C Ren, S Lin, Z Zhou, H Wu, J Yin, L Tan Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis Respiratory Research, 2022-10-01;23(1):269. 2022-10-01 [PMID: 36183124] (Cell Culture, Human)
• MC Jaboreck, JL Lühmann, M Mielenz, F Stanke, G Göhring, U Martin, R Olmer, S Merkert Generation of two TMEM16A knockout iPSC clones each from a healthy human iPSC line, from a Cystic Fibrosis patient specific line with p.Phe508del mutation and from the gene corrected iPSC line Stem Cell Research, 2022-09-14;64(0):102918. 2022-09-14 [PMID: 36162332] (Bioassay, Human)
• V Lungova, K Wendt, SL Thibeault Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling Oncogene, 2022-08-23;0(0):. 2022-08-23 [PMID: 35770504] (Bioassay, Human)
• A Chansaenro, C Adine, S Charoenlap, S Roytrakul, L Sariya, T Osathanon, S Rungarunle, G Urkasemsin, R Chaisupara, S Yodmuang, GR Souza, JN Ferreira Magnetic bioassembly platforms towards the generation of extracellular vesicles from human salivary gland functional organoids for epithelial repair Bioactive materials, 2022-02-16;18(0):151-163. 2022-02-16 [PMID: 35387159] (Bioassay, Human)
• S Imamura, K Yoshimoto, S Terada, K Takamuro, KI Kamei In vitro culture at 39��C during hepatic maturation of human ES cells facilitates hepatocyte-like cell functions Scientific Reports, 2022-03-25;12(1):5155. 2022-03-25 [PMID: 35338220] (Bioassay, Human)
• AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells Cell Stem Cell, 2021-12-01;0(0):. 2021-12-01 [PMID: 34856121] (Bioassay, Human)
• L Johnson Ch, H Lahlou, C Steinacher, S Assou, Y Messat, J Dudás, A Edge, B Crespo, M Crosier, C Sergi, A Schrott-Fi, A Zine Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs International Journal of Molecular Sciences, 2021-10-07;22(19):. 2021-10-07 [PMID: 34639189] (Bioassay, Human)
• K Gkatzis, P Panza, S Peruzzo, DY Stainier Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures Elife, 2021-09-29;10(0):. 2021-09-29 [PMID: 34586063] (Bioassay, Mouse)
• Y Aghazadeh, F Poon, F Sarangi, FTM Wong, ST Khan, X Sun, R Hatkar, BJ Cox, SS Nunes, MC Nostro Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models Cell Stem Cell, 2021-09-03;0(0):. 2021-09-03 [PMID: 34480863] (Bioassay, Human)
• MO Lee, SG Lee, CR Jung, YS Son, JW Ryu, KB Jung, JH Ahn, JH Oh, HA Lee, JH Lim, J Kim, I Jang, J Choi, J Jung, K Park, B Lee, DS Kim, MY Son, HS Cho Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells Nature Communications, 2021-07-23;12(1):4492. 2021-07-23 [PMID: 34301945] (Bioassay, Human)
• AL Rodrigues, HY Liu, YW Chen, M Porotto, A Moscona, HW Snoeck The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D Nature Protocols, 2021-03-01;0(0):. 2021-03-01 [PMID: 33649566] (Bioassay, Human)
• H Tomita, K Tanaka, A Hirata, H Okada, H Imai, Y Shirakami, K Ohnishi, S Sugie, H Aoki, Y Hatano, K Noguchi, T Kanayama, A Niwa, N Suzui, T Miyazaki, T Tanaka, H Akiyama, M Shimizu, K Yoshida, A Hara Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas Cell Reports, 2021-02-23;34(8):108772. 2021-02-23 [PMID: 33626352] (Human)
• L Cui, J Zheng, Q Zhao, JR Chen, H Liu, G Peng, Y Wu, C Chen, Q He, H Shi, S Yin, RA Friedman, Y Chen, MX Guan Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss JCI Insight, 2020-12-03;5(23):. 2020-12-03 [PMID: 33268592] (Bioassay, Human)
• FJ Hawkins, S Suzuki, ML Beermann, C Barillà, R Wang, C Villacorta, A Berical, JC Jean, J Le Suer, T Matte, C Simone-Roa, Y Tang, TM Schlaeger, AM Crane, N Matthias, SXL Huang, SH Randell, J Wu, JR Spence, G Carraro, BR Stripp, A Rab, EJ Sorsher, A Horani, SL Brody, BR Davis, DN Kotton Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells Cell Stem Cell, 2020-10-23;0(0):. 2020-10-23 [PMID: 33098807] (Bioassay, Human)
• J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Lindstrom-, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response Cell Stem Cell, 2020-09-18;0(0):. 2020-09-18 [PMID: 32979316] (Bioassay, Human)
• MT Hoffman, SB Kemp, DJ Salas-Esca, Y Zhang, NG Steele, S The, D Long, S Benitz, W Yan, RF Margolskee, F Bednar, M Pasca di M, HJ Wen, HC Crawford The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice Cell Mol Gastroenterol Hepatol, 2020-08-31;0(0):. 2020-08-31 [PMID: 32882403] (Cell Culture, Mouse)
• F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq, 2020-09-15;0(0):. 2020-09-15 [PMID: 32839764] (Bioassay, Human)
• J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response bioRxiv, 2020-08-06;0(0):. 2020-08-06 [PMID: 32637964] (Bioassay, Human)
• L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020-06-19;27(1):125-136.e7. 2020-06-19 [PMID: 32579880] (Bioassay, Human)
• L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020;27(1):125-136.e7. 2020 [PMID: 32579880] (Bioassay, Human)
• N Chanthra, T Abe, M Miyamoto, K Sekiguchi, C Kwon, Y Hanazono, H Uosaki A Novel Fluorescent Reporter System Identifies Laminin-511/521 as Potent Regulators of Cardiomyocyte Maturation Sci Rep, 2020-03-06;10(1):4249. 2020-03-06 [PMID: 32144297] (Bioassay, Human)
• R Matsumoto, H Suga, T Aoi, H Bando, H Fukuoka, G Iguchi, S Narumi, T Hasegawa, K Muguruma, W Ogawa, Y Takahashi Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells J. Clin. Invest., 2020-02-03;130(2):641-654. 2020-02-03 [PMID: 31845906] (Bioassay, Human)
• A Sahabian, M Sgodda, O Naujok, R Dettmer, J Dahlmann, F Manstein, T Cantz, R Zweigerdt, U Martin, R Olmer Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential Cells, 2019-12-04;8(12):. 2019-12-04 [PMID: 31817235] (Bioassay, Human)
• W Liang, P Han, EH Kim, J Mak, R Zhang, AG Torrente, JI Goldhaber, E Marbán, HC Cho Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells Stem Cells, 2019-12-30;0(0):. 2019-12-30 [PMID: 31648393] (Bioassay, Mouse)
• T Yung, F Poon, M Liang, S Coquenlorg, EC McGaugh, CC Hui, MD Wilson, MC Nostro, TH Kim Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals Nat Commun, 2019-10-11;10(1):4647. 2019-10-11 [PMID: 31604927] (Bioassay, Human)
• V Lungova, X Chen, Z Wang, C Kendziorsk, SL Thibeault Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure Nat Commun, 2019-09-24;10(1):4161. 2019-09-24 [PMID: 31551422] (Bioassay, Human)
• K Suzuki, M Koyanagi-A, K Uehara, N Hinata, M Fujisawa, T Aoi Directed differentiation of human induced pluripotent stem cells into mature stratified bladder urothelium Sci Rep, 2019-07-19;9(1):10506. 2019-07-19 [PMID: 31324820] (Cell Culture, Human)
• RMJ Genga, EM Kernfeld, KM Parsi, TJ Parsons, MJ Ziller, R Maehr Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development Cell Rep, 2019-04-16;27(3):708-718.e10. 2019-04-16 [PMID: 30995470] (Bioassay, Human)
• Y Toba, A Kiso, S Nakamae, F Sakurai, K Takayama, H Mizuguchi FGF signal is not required for hepatoblast differentiation of human iPS cells Sci Rep, 2019-03-06;9(1):3713. 2019-03-06 [PMID: 30842525] (Bioassay, Human)
• H Noguchi, C Miyagi-Shi, Y Nakashima, T Kinjo, N Kobayashi, I Saitoh, M Watanabe, AMJ Shapiro, T Kin Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors Mol Ther Methods Clin Dev, 2019-01-29;13(0):243-252. 2019-01-29 [PMID: 30828587] (Bioassay, Human)
• C Kumtornrut, T Yamauchi, S Koike, S Aiba, K Yamasaki Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts J. Dermatol. Sci., 2019-01-26;0(0):. 2019-01-26 [PMID: 30792099] (Bioassay, Human)
• N Muraoka, K Nara, F Tamura, H Kojima, H Yamakawa, T Sadahiro, K Miyamoto, M Isomi, S Haginiwa, H Tani, S Kurotsu, R Osakabe, S Torii, S Shimizu, H Okano, Y Sugimoto, K Fukuda, M Ieda Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming Nat Commun, 2019-02-20;10(1):674. 2019-02-20 [PMID: 30787297] (Bioassay, Mouse)
• AJ Miller, BR Dye, D Ferrer-Tor, DR Hill, AW Overeem, LD Shea, JR Spence Generation of lung organoids from human pluripotent stem cells in vitro Nat Protoc, 2019-02-01;14(2):518-540. 2019-02-01 [PMID: 30664680] (Bioassay, Human)
• MA Scavuzzo, J Chmielowie, D Yang, K Wamble, LS Chaboub, L Duraine, B Tepe, SM Glasgow, BR Arenkiel, C Brou, B Deneen, M Borowiak Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA Cell Rep, 2018-12-26;25(13):3811-3827.e7. 2018-12-26 [PMID: 30590051] (Bioassay, Mouse)
• H Chagraoui, MS Kristianse, JP Ruiz, A Serra-Barr, J Richter, E Hall-Ponse, N Gray, D Waithe, K Clark, P Hublitz, E Repapi, G Otto, P Sopp, S Taylor, S Thongjuea, P Vyas, C Porcher SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells Nat Commun, 2018-12-18;9(1):5375. 2018-12-18 [PMID: 30560907] (Bioassay, Human)
• TR Broda, KW McCracken, JM Wells Generation of human antral and fundic gastric organoids from pluripotent stem cells Nat Protoc, 2019-01-01;14(1):28-50. 2019-01-01 [PMID: 30470820] (Bioassay, Human)
• Y Zhang, Y Yang, M Jiang, SX Huang, W Zhang, D Al Alam, S Danopoulos, M Mori, YW Chen, R Balasubram, SM Chuva de S, C Serra, M Bialecka, E Kim, S Lin, ALR Toste de C, PN Riccio, WV Cardoso, X Zhang, HW Snoeck, J Que 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling Cell Stem Cell, 2018-09-20;0(0):. 2018-09-20 [PMID: 30244870] (Bioassay, Human)
• JP Ng-Blichfe, A Schrik, RK Kortekaas, JA Noordhoek, IH Heijink, PS Hiemstra, J Stolk, M Königshoff, R Gosens Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation EBioMedicine, 2018-09-17;36(0):461-474. 2018-09-17 [PMID: 30236449] (Bioassay, Human)
• R Cruz-Acuña, M Quirós, S Huang, D Siuda, JR Spence, A Nusrat, AJ García PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery Nat Protoc, 2018-09-01;0(0):. 2018-09-01 [PMID: 30190557] (Bioassay, Human)
• S Zhang, C Zhao, S Liu, Y Wang, Y Zhao, W Guan, Z Zhu Characteristics and multi?lineage differentiation of bone marrow mesenchymal stem cells derived from the Tibetan mastiff Mol Med Rep, 2018-06-15;0(0):. 2018-06-15 [PMID: 29916546] (Bioassay, Canine)
• H Lahlou, A Lopez-Juar, A Fontbonne, E Nivet, A Zine Modeling human early otic sensory cell development with induced pluripotent stem cells PLoS ONE, 2018-06-14;13(6):e0198954. 2018-06-14 [PMID: 29902227] (Bioassay, Human)
• X Guo, Y Xu, Z Wang, Y Wu, J Chen, G Wang, C Lu, W Jia, J Xi, S Zhu, Z Jiapaer, X Wan, Z Liu, S Gao, J Kang A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis Cell Stem Cell, 2018-05-10;0(0):. 2018-05-10 [PMID: 29754779] (Bioassay, Mouse)
• EJ Ostrin, DR Little, KN Gerner-Mau, EA Sumner, R Ríos-Corzo, E Ambrosio, SE Holt, NR Forcioli-C, H Akiyama, SM Hanash, S Kimura, SXL Huang, J Chen Beta-Catenin maintains lung epithelial progenitors after lung specification Development, 2018-03-09;0(0):. 2018-03-09 [PMID: 29440304] (Bioassay, Human)
• B Memon, M Karam, S Al-Khawaga, EM Abdelalim Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1 Stem Cell Res Ther, 2018-01-23;9(1):15. 2018-01-23 [PMID: 29361979] (Bioassay, Human)
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• CE Weeden, Y Chen, SB Ma, Y Hu, G Ramm, KD Sutherland, GK Smyth, ML Asselin-La Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway PLoS Biol, 2017-01-26;15(1):e2000731. 2017-01-26 [PMID: 28125611] (Bioassay, Human)
• Retinal Proteoglycans Act as Cellular Receptors for Basement Membrane Assembly to Control Astrocyte Migration and Angiogenesis Cell Rep, 2016-11-08;17(7):1832-1844. 2016-11-08 [PMID: 27829154] (Binding Assay, Mouse)
• TGF-?1 promotes acinar to ductal metaplasia of human pancreatic acinar cells Sci Rep, 2016-08-03;6(0):30904. 2016-08-03 [PMID: 27485764] (Bioassay, Human)
• Maya Valeska Gozali Photodynamic therapy inhibit Fibroblast Growth Factor-10 induced keratinocyte differentiation and proliferation through ROS in Fibroblast Growth Factor Receptor-2b pathway Sci Rep, 2016-06-07;6(0):27402. 2016-06-07 [PMID: 27273653] (Bioassay, Human)
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• Comps-Agrar L, Dunshee D, Eaton D, Sonoda J Unliganded fibroblast growth factor receptor 1 forms density-independent dimers. J Biol Chem, 2015-08-13;290(40):24166-77. 2015-08-13 [PMID: 26272615] (Bioassay, Human)
• Calderon-Gierszal E, Prins G Directed Differentiation of Human Embryonic Stem Cells into Prostate Organoids In Vitro and its Perturbation by Low-Dose Bisphenol A Exposure. PLoS ONE, 2015-07-29;10(7):e0133238. 2015-07-29 [PMID: 26222054] (Bioassay, Human)
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• Wong , Amy P, Chin , Stephani, Xia , Sunny, Garner , Jodi, Bear , Christin, Rossant , Janet Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells. Nat Protoc, 2015-02-05;10(3):363-81. 2015-02-05 [PMID: 25654755] (Bioassay, Human)
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• Dalle Nogare D, Somers K, Rao S, Matsuda M, Reichman-Fried M, Raz E, Chitnis A Leading and trailing cells cooperate in collective migration of the zebrafish posterior lateral line primordium. Development, 2014-07-25;141(16):3188-96. 2014-07-25 [PMID: 25063456] (In Vivo, Zebrafish)
• Pethe , Prasad, Nagvenkar , Punam, Bhartiya , Deepa Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro. BMC Cell Biol, 2014-05-24;15(0):18. 2014-05-24 [PMID: 24885493] (Bioassay, Human)
• Kanehira M, Kikuchi T, Santoso A, Tode N, Hirano T, Ohkouchi S, Tamada T, Sugiura H, Harigae H, Ichinose M Human marrow stromal cells downsize the stem cell fraction of lung cancers by fibroblast growth factor 10. Mol Cell Biol, 2014-05-27;34(15):2848-56. 2014-05-27 [PMID: 24865969] (Bioassay, Human)
• Ohnuma , Kiyoshi, Fujiki , Ayaka, Yanagihara , Kana, Tachikawa , Saoko, Hayashi , Yohei, Ito , Yuzuru, Onuma , Yasuko, Chan , Techuan, Michiue , Tatsuo, Furue , Miho K, Asashima , Makoto Enzyme-free passage of human pluripotent stem cells by controlling divalent cations. Sci Rep, 2014-04-11;4(0):4646. 2014-04-11 [PMID: 24721898] (Bioassay, Human)
• Takeuchi , Hiroki, Nakatsuji , Norio, Suemori , Hirofumi Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture. Sci Rep, 2014-03-27;4(0):4488. 2014-03-27 [PMID: 24671046] (Bioassay, Human)
• Hannan , Nicholas, Fordham , Robert P, Syed , Yasir A, Moignard , Victoria, Berry , Andrew, Bautista , Ruben, Hanley , Neil A, Jensen , Kim B, Vallier , Ludovic Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Reports, 2013-10-10;1(4):293-306. 2013-10-10 [PMID: 24319665] (Bioassay, Human)
• Huang , Sarah X, Islam , Mohammad, O'Neill , John, Hu , Zheng, Yang , Yong-Gua, Chen , Ya-Wen, Mumau , Melanie, Green , Michael, Vunjak-Novakovic , Gordana, Bhattacharya , Jahar, Snoeck , Hans-Wil Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol, 2013-12-01;32(1):84-91. 2013-12-01 [PMID: 24291815] (Bioassay, Human)
• Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann J, Miyazaki S, Miyazaki J, Szot G, Bottino R, Kim S Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife, 2013-11-19;2(0):e00940. 2013-11-19 [PMID: 24252877] (Bioassay, Human)
• Weedon M, Cebola I, Patch A, Flanagan S, De Franco E, Caswell R, Rodriguez-Segui S, Shaw-Smith C, Cho C, Lango Allen H, Houghton J, Roth C, Chen R, Hussain K, Marsh P, Vallier L, Murray A, Ellard S, Ferrer J, Hattersley A Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. Nat Genet, 2013-11-10;46(1):61-4. 2013-11-10 [PMID: 24212882] (Bioassay, Human)
• Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol Ther, 2012-11-27;21(1):228-39. 2012-11-27 [PMID: 23183535] (Bioassay, Human)
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• Patel N, Sharpe PT, Miletich I Coordination of epithelial branching and salivary gland lumen formation by Wnt and FGF signals. Dev. Biol., 2011-07-23;358(1):156-67. 2011-07-23 [PMID: 21806977] (Bioassay, Mouse)
• Tomlinson DC, Knowles MA Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am. J. Pathol., 2010-10-01;177(5):2379-86. 2010-10-01 [PMID: 20889570] (Bioassay, Human)
• Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell, 2009-04-03;4(4):348-58. 2009-04-03 [PMID: 19341624] (Bioassay, Human, Mouse)
• Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, Suzuki H, Aizawa S, Arakaki M, Yuasa K, Oka K, Chai Y, Nonaka K, Fukumoto S Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J. Biol. Chem., 2008-06-17;283(34):23139-49. 2008-06-17 [PMID: 18559345] (Bioassay, Mouse)
• Patel VN, Likar KM, Zisman-Rozen S, Cowherd SN, Lassiter KS, Sher I, Yates EA, Turnbull JE, Ron D, Hoffman MP Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. J. Biol. Chem., 2008-01-28;283(14):9308-17. 2008-01-28 [PMID: 18230614] (Bioassay, Mouse)
• Cho YM, Lim JM, Yoo DH, Kim JH, Chung SS, Park SG, Kim TH, Oh SK, Choi YM, Moon SY, Park KS, Lee HK Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells. Biochem. Biophys. Res. Commun., 2007-12-04;366(1):129-34. 2007-12-04 [PMID: 18060872] (Bioassay, Human)
• Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development, 2007-10-24;134(23):4177-86. 2007-10-24 [PMID: 17959718] (Bioassay, Mouse)
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Bioinformatics

• Gene Symbol: FGF10
• Uniprot:
  • O15520()