Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
Protein G purified
Alternate Names for Rad1 Antibody
cell cycle checkpoint protein Hrad1
checkpoint control protein HRAD1
DNA repair exonuclease rad1 homolog
DNA repair exonuclease REC1
exonuclease homolog RAD1
RAD1 (S. pombe) homolog
RAD1 homolog (S. pombe)
Rad1-like DNA damage checkpoint protein
REC1cell cycle checkpoint protein RAD1
The structure and integrity of DNA molecules can be spontaneously affected through intrinsic instability of chemical bonds in DNA or can be induced by chemical compounds and irradiation. DNA lesions are of many different types including single and double-strand breaks, inter and intra-strand cross-links and different kinds of base modification. DNA lesions hamper processes like transcription and replication resulting in cell cycle arrest, apoptosis and genomic instability (mutagenesis). DNA lesions have been implicated in many distinct genetically inherited diseases, in carcinogenesis, origin of genetic disorders and in aging. Rad1 is an essential component of cell cycle checkpoints activated by DNA damage and incomplete DNA replication. Six Rad proteins (Rad1, Rad3, Rad9, Rad17, Rad26, and Hus1) are involved in the early steps of DNA damage checkpoint response in S. pombe. Human HRAD1 gene is located on chromosome 5p13.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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