PTENP1 [p Ser29, p Thr32] Antibody

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Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ca, PmSpecies Glossary
Applications WB, ELISA
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.87 mg/ml

Order Details

PTENP1 [p Ser29, p Thr32] Antibody Summary

Immunogen
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to amino acids 223-237 of human PTENP1 protein.
Modification
p Ser29, p Thr32
Specificity
This antibody is directed against the phosphorylated form of human PTEN-P1 protein at the pS29 and pT32 residues.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTENP1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:2000
  • ELISA 1:20000-1:80000
Application Notes
This affinity purified antibody has been tested for use in ELISA and western blot. Expect a band approximately 41 kDa in size corresponding - PTEN-P1 protein by western blotting in the appropriate cell lysate or extract.

Reactivity Notes

Chimpanzee 100%

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative
0.01% Sodium Azide
Concentration
0.87 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PTENP1 [p Ser29, p Thr32] Antibody

  • phosphatase and tensin homolog pseudogene 1
  • psiPTEN
  • PTEN2
  • PTH2, PTEN-rs

Background

This gene (PTENP1) is a highly homologous pseudogene of PTEN. PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol PTENP1