PTEN Products

Antibodies
PTEN Antibody (217702) [Uncon ...
PTEN Antibody (217702) [Unconjugated]
MAB847
Species: Hu, Mu, Rt
Applications: WB, IHC, CyTOF-ready, ICFlow
Host: Mouse Monoclonal
PTEN Antibody
PTEN Antibody
AF847
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, CyTOF-ready, ICFlow
Host: Rabbit Polyclonal
Conjugate Catalog # Availability Size Price
PTEN Antibody
PTEN Antibody
NB100-2229
Species: Hu, Mu, Po, Bv, Ca, Ch, Eq, GP, Mk, Pm, Rb, Tr
Applications: WB, ICC/IF, IHC, IHC-P, IP, PLA
Host: Rabbit Polyclonal
Lysates
PTEN Overexpression Lysate (D ...
PTEN Overexpression Lysate (Denatu...
H00005728-T02
Species: Hu
Applications: WB
PTEN Overexpression Lysate (D ...
PTEN Overexpression Lysate (Denatu...
H00005728-T01
Species: Hu
Applications: WB
Proteins
Recombinant Human PTEN Protei ...
Recombinant Human PTEN Protein
H00005728-P02
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human PTEN Protei ...
Recombinant Human PTEN Protein
H00005728-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human PTEN Protei ...
Recombinant Human PTEN Protein
H00005728-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
PTEN RNAi
PTEN RNAi
H00005728-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

PTEN is a protein tyrosine phosphatase that acts as a tumor suppressor, as a lipid phosphatase that dephosphorylates the D3 position of phosphatidylinositol 3,4,5-trisphosphate and as an antagonist of the PI3k/AKT signaling pathway (1-3). PTEN structural domains includes an N-terminal phosphatase domain, a lipid binding C2 domain and a 50-amino acid C-terminal tail that contains a PD biding sequence (5). Phosporylation of the tail of the protein will suppress its activity and modify its conformation to a

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 5728
Alternate Names
  • EC 3.1.3.67
  • BZS
  • EC 3.1.3.48
  • EC 3.1.3.16,10q23del
  • GLM2
  • phosphatidylinositol-34,5-trisphosphate 3-phosphatase and dual-specificityprotein phosphatase PTEN
  • Mutated in multiple advanced cancers 1
  • MMAC1 phosphatase and tensin homolog deleted on chromosome 10
  • PTEN1
  • TEP1MHAM
  • MMAC1MGC11227
  • phosphatase and tensin homologDEC

Research Areas for PTEN

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Cell Biology
Lipid and Metabolism
mTOR Pathway
Phospho-Specific
Protein Phosphatase
Signal Transduction
Transcription Factors and Regulators
Tumor Suppressors

Bioinformatics Tool for PTEN

Discover related pathways, diseases and genes to PTEN. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related PTEN Blog Posts

Check out the latest blog posts on PTEN.
The effects of curcumin on IKB Alpha and the NFkB signaling pathway
The IKK complex, or inhibitor of NFkB kinase, is composed of IKK alpha and IKK beta.  These kinases are at the core of the NFkB signaling cascade.  The NFkB family is made up of transcription factors that are kept inactive in the cytoplasm through...    Read more.
Carbonic anhydrase IX (CAIX) - a reliable histochemical marker of hypoxia
Carbonic anhydrase IX is a member of the carbonic anhydrase family. This family consists of catalytic enzymes capable of converting carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. This family of molecules is abundantly e...    Read more.
CAIX - One of the Best Cellular Markers of Hypoxia
The protein, carbonic anhydrase IX, belongs to the carbonic anhydrase family which consists of enzymes that rapidly convert carbon dioxide and water into the end products of carbonic acid, protons, and bicarbonate ions. These enzymes play a widespread...    Read more.
Getting SHIP-shape Over Tumour Suppression
PTEN antibodies have shown PTEN to be an important tumor suppressor and, in mutated form, a factor in cancer development. However, a recent study, led by Robert Rickert, shows that the SHIP gene may also be an important tumor suppressor in B-cell lymp...    Read more.
PTEN Antibodies and Cancer Research
Phosphatase and tensin homologue (PTEN) antibodies are important tools for cancer research. PTEN is an important tumor suppressor but, in mutated form, is also expressed in a high number of cancers. We at Novus Biologicals have a wide PTEN antibody da...    Read more.
Read more PTEN related blogs.