PTBP1 Antibody Pair

Product Discontinued

PTBP1 Antibody Pair Summary

• Description: Quality control test: Immunoprecipitation-Western Blot (IP-WB). This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
  
  
• Antibody pair for IP: mouse monoclonal anti-PTBP1 (300 ug)
• Antibody pair for WB: rabbit polyclonal anti-PTBP1 (50 ul)
• Clonality: Polyclonal
• Gene: PTBP1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for PTBP1 Antibody Pair

• Heterogeneous nuclear ribonucleoprotein I
• heterogeneous nuclear ribonucleoprotein polypeptide I
• hnRNP I
• HNRNPI
• HNRNP-I
• HNRPI
• MGC10830
• MGC8461
• polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoproteinI)
• polypyrimidine tract binding protein 1
• polypyrimidine tract-binding protein 1
• pPTB
• PTB-1
• PTB2
• PTB3
• PTB4
• PTB57 kDa RNA-binding protein PPTB-1
• PTB-T
• RNA-binding protein

Background

PTBP1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: PTBP1