PRDM16/MEL1 Antibody

Images

 
Western Blot: PRDM16/MEL1 Antibody [NBP1-71992] - Analysis of anti-PRDM16 antibody with rat brain tissue lysate.
Immunocytochemistry/ Immunofluorescence: PRDM16/MEL1 Antibody [NBP1-71992] - Analysis of anti-PRDM16 antibody with human brain cells.
Immunohistochemistry-Paraffin: PRDM16/MEL1 Antibody [NBP1-71992] - Analysis of anti-PRDM16 antibody with human skin at concentration 5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

PRDM16/MEL1 Antibody Summary

Immunogen
A 17 amino acid peptide from near the carboxy terminus of human PRDM16.
Epitope
C-Terminus
Specificity
Human PRDM16
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PRDM16
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
  • ELISA 1:100 - 1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PRDM16/MEL1 Antibody

  • MDS1/EVI1-like gene 1
  • MEL1
  • MEL1KIAA1675PFM13MGC166915
  • PFM13
  • PR domain containing 16
  • PR domain zinc finger protein 16
  • PR domain-containing protein 16
  • PRDM16
  • Transcription factor MEL1

Background

The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PRDM16
Entrez