WB, ELISA, IHCHost:
Species: Hu, Mu, Rt
Applications: WB, ELISA
Host: Rabbit Polyclonal
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
|Product By Gene ID
- PR domain-containing protein 16
- PR domain zinc finger protein 16
- MDS1/EVI1-like gene 1
- Transcription factor MEL1
- PR domain containing 16
Research Areas for PRDM16/MEL1
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Bioinformatics Tool for PRDM16/MEL1
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