Species: Hu, Mu
Applications: WB, ELISA, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, ELISA, Flow
Host: Goat Polyclonal
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
63976 |
| Alternate Names |
- MDS1/EVI1-like gene 1
- MEL1KIAA1675PFM13MGC166915
- PR domain containing 16
- PR domain zinc finger protein 16
- PR domain-containing protein 16
- Transcription factor MEL1
|
Research Areas for PRDM16/MEL1
Find related products by research area and learn more about each of the different research areas below.
Chromatin Research
