PLTP Antibody

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Western Blot: PLTP Antibody [NB400-106] - Activation of PLTP in STAT3 pathway. RA-FLS were stimulated for 24 hours with rhPLTP at the indicated concentrations. Western blot analyses analyzed cell lysates for ...read more
Immunocytochemistry/ Immunofluorescence: PLTP Antibody [NB400-106] - PLTP antibody was tested in HeLa cells with FITC (green). Nuclei and alpha-tubulin were counterstained with Dapi (blue) and Dylight 550 (red).
Immunohistochemistry-Paraffin: PLTP Antibody [NB400-106] - PLTP was detected in immersion fixed paraffin-embedded sections of human placenta using Rabbit Anti-Human PLTP polyclonal Antibody (Catalog # NB400-106) at ...read more
Western Blot: PLTP Antibody [NB400-106] - WB analysis of PLTP in human brain lysate.
Immunohistochemistry: PLTP Antibody [NB400-106] - PLTP antibody expression in RA synovial tissues. (A) Immuno-histological analyses used RA patients synovial tissue sections (n=5). They were stained for PLTP or ...read more
Immunohistochemistry: PLTP Antibody [NB400-106] - PLTP expression and activity in OA and RA joints. (A) Western blot analysis quantified PLTP protein level in FLS and was normalized using beta-actin. Expressed as a ...read more
Immunohistochemistry: PLTP Antibody [NB400-106] - Recombinant PLTP antibody induced cytokine production and FLS proliferation, independent of its lipid transfer ability. (A) RA-FLS were stimulated for 48 hours with PLTP ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

PLTP Antibody Summary

Immunogen
A partial peptide of human PLTP. [UniProt# P55058]
Localization
Secreted
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PLTP
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500
  • Immunocytochemistry/Immunofluorescence 1:50-1:100
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Paraffin 1:200
Application Notes
This PLTP antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections and Western Blot, where a band is seen at ~55kDa representing PLTP. It does not exhibit neutralizing activity. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control
Brain Lysate (NB820-59657)
PLTP Lysate (NBL1-14528)
Brain Lysate (NB820-59177)
Reviewed Applications
Read 1 Review rated 5
using
NB400-106 in the following applications:

Publications
Read Publications using
NB400-106 in the following applications:

  • IHC
    1 publication
  • 2 publications
  • WB
    2 publications

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
0.02% Sodium Azide
Purity
Unpurified

Alternate Names for PLTP Antibody

  • HDLCQ9
  • Lipid transfer protein II
  • phospholipid transfer protein
  • PLTP

Background

PLTP (phospholipid transfer protein) belongs to lipid transfer/lipopolysaccharide-binding proteins (BPI/LBP) family and it is a monomeric sectered protein expressed ubiquitously with highest expression in liver, one of the major sites of lipoprotein production and degradation. PLTP converts HDL into larger and smaller particles, and play a key role in extracellular phospholipid transport as well as modulation of HDL particles. Plasma PLTP is also considered a nonspecific lipid transfer protein because, along with phospholipids, it can also transfer alpha-tocopherol, diacylglycerol, cerebroside, and lipopolysaccharides. PLTP deficient mice depicts lowered susceptibility for atherosclerosis, whereas, PLTP transgenic mice have more atherosclerosis. In humans, an increased PLTP activity been linked to several conditions including type I/II diabetes mellitus, metabolic syndrome, obesitas, increased risk of coronary artery disease and cardiovascular disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PLTP Antibody (NB400-106)(7)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IHC, IHC-P, WB.


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(1)
IHC-P
(2)
WB
(2)
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(4)
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(1)
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Showing Publications 1 - 7 of 7.
Publications using NB400-106 Applications Species
Ochieng P, Nath S, Macarulay R et al. Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation. Sci Rep. Oct 18 2018 [PMID: 30337619] (WB, Human) WB Human
Audo R, Deckert V, Daien CI et al. PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity. PLoS ONE. Mar 22 2018 [PMID: 29565987] (IHC-P, Human) IHC-P Human
Smagris E, Gilyard S, BasuRay S et al. Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins. J Biol Chem 2016 May 13 [PMID: 27013658]
Pahl MV, Ni Z, Sepassi L et al. Plasma phospholipid transfer protein, cholesteryl ester transfer protein lecithin:cholesterol acyltransferase in end-stage renal disease (ESRD). Nephrol Dial Transplant;24(8):2541-2546. 2009 [PMID: 19297356]
He Y, Greene DJ, Kinter M et al. Control of cholesteryl ester transfer protein activity by sequestration of lipid transfer inhibitor protein in an inactive complex. J Lipid Res;49(7):1529-1537. 2008 [PMID: 18369235] (WB, Human) WB Human
Valenta, DT et al. Atheroprotective potential of macrophage-derived phospholiped transfer protein in low-density lipoprotein receptor-deficient mice is overcome by apolipoprotein AI overexpression. Arterioscler. Thromb. Vasc. Biol. 26:1572-1578. 2006 [PMID: 16675720] (IHC, Mouse) IHC Mouse
Desrumaux CM, Mak PA, Boisvert WA et al. Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells. J Lipid Res;44(8):1453-61. 2003 Aug. [PMID: 1273030] (IHC-P, Human) IHC-P Human

Review for PLTP Antibody (NB400-106) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Mouse.

Reviews using NB400-106:
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WB
(1)
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Mouse
(1)
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Images Ratings Applications Species Date Details
Western Blot PLTP NB400-106
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reviewed by:
Anonymous
WB Mouse 03/06/2018
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Summary

ApplicationWestern Blot
Sample TestedLiver
SpeciesMouse
Lotb1

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Control Lysate(s)

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Recent Reviews

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Anonymous
03/06/2018
Application: WB
Species: Mouse

Bioinformatics

Gene Symbol PLTP
Entrez
Uniprot