PEDFR/PNPLA2/ATGL Antibody [Biotin]

Product Discontinued

PEDFR/PNPLA2/ATGL Antibody [Biotin] Summary

• Immunogen: A synthetic peptide within the C-terminal region (residues 400-500) of human ATGL. [Accession# NP_005171]
• Localization: Cytoplasm, Adiposomes
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PNPLA2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: This ATGL antibody is useful for Western Blot and Immunocytochemistry/Immunofluorescence. In ICC/IF, cytoplasmic/adiposomal staining was observed in HeLa cells.
• Readout System:
  • Streptavidin Native Protein NBP2-29367
  • Streptavidin Native Protein NBP2-29370
  • Streptavidin Native Protein NBP2-29371

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for PEDFR/PNPLA2/ATGL Antibody [Biotin]

• Adipose triglyceride lipase
• ATGL
• ATGL1110001C14Rik
• Calcium-independent phospholipase A2
• Desnutrin
• EC 3.1.1.3
• FP17548
• IPLA2-zeta
• patatin-like phospholipase domain containing 2
• patatin-like phospholipase domain-containing protein 2
• patatin-like phospholipase domain-containing protein 2-like
• PEDF R
• PEDFR
• PEDF-R
• Pigment epithelium-derived factor
• PNPLA2
• Transport-secretion protein 2
• transport-secretion protein 2.2
• triglyceride hydrolase
• TTS2
• TTS2.2
• TTS-2.2
• TTS2DKFZp667M109

Background

Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PNPLA2