Human Serpin F1/PEDF DuoSet ELISA, 5 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Serpin F1/PEDF DuoSet ELISA, 5 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: SERPINF1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Serpin F1/PEDF DuoSet ELISA, 5 Plate

• Cell proliferation-inducing gene 35 protein
• EPC-1
• EPC-1PIG35
• PEDF
• PEDFpigment epithelium-derived factor
• pigment epithelium derived factor), member 1
• proliferation-inducing protein 35
• serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin
• Serpin F1
• serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epitheliumderived factor), member 1

Background

The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Publications for Serpin F1/PEDF (DY1177-05)(16)

Publications using DY1177-05

• L Chen, ND Perera, AJ Karoukis, KL Feathers, RR Ali, DA Thompson, AT Fahim Oxidative stress differentially impacts apical and basolateral secretion of angiogenic factors from human iPSC-derived retinal pigment epithelium cells Scientific Reports, 2022;12(1):12694. 2022 [PMID: 35882889] (Human)
• MC Ebeling, CR Fisher, RJ Kapphahn, MR Stahl, S Shen, J Qu, SR Montezuma, DA Ferrington Inflammasome Activation in Retinal Pigment Epithelium from Human Donors with Age-Related Macular Degeneration Cells, 2022;11(13):. 2022 [PMID: 35805159] (Human)
• A Riley, H Jones, J England, D Kuvshinov, V Green, J Greenman Identification of soluble tissue-derived biomarkers from human thyroid tissue explants maintained on a microfluidic device Oncology Letters, 2021;22(5):780. 2021 [PMID: 34594421] (Human)
• MC Ebeling, Z Geng, RJ Kapphahn, H Roehrich, SR Montezuma, JR Dutton, DA Ferrington Impaired Mitochondrial Function in iPSC-Retinal Pigment Epithelium with the Complement Factor H Polymorphism for Age-Related Macular Degeneration Cells, 2021;10(4):. 2021 [PMID: 33918210] (Human)
• X Bao, J Zeng, H Huang, C Ma, L Wang, F Wang, X Liao, X Song Cancer-Targeted PEDF-DNA Therapy for Metastatic Colorectal Cancer Int J Pharm, 2019;0(0):118999. 2019 [PMID: 31893541] (Mouse)
• H Wang, Y Yang, M Yang, X Li, J Tan, Y Wu, Y Zhang, Y Li, B Hu, S Deng, F Yang, S Gao, H Li, Z Yang, H Chen, W Cai Pigment Epithelial-Derived Factor Deficiency Accelerates Atherosclerosis Development via Promoting Endothelial Fatty Acid Uptake in Mice With Hyperlipidemia J Am Heart Assoc, 2019;8(22):e013028. 2019 [PMID: 31711388] (Human)
• C Li, Z Huang, L Zhu, X Yu, T Gao, J Feng, H Hong, H Yin, T Zhou, W Qi, Z Yang, C Liu, X Yang, G Gao The contrary intracellular and extracellular functions of PEDF in HCC development Cell Death Dis, 2019;10(10):742. 2019 [PMID: 31582735] (Xenograft)
• G Sagaradze, O Grigorieva, P Nimiritsky, N Basalova, N Kalinina, Z Akopyan, A Efimenko Conditioned Medium from Human Mesenchymal Stromal Cells: Towards the Clinical Translation Int J Mol Sci, 2019;20(7):. 2019 [PMID: 30987106] (Human)
• Y Simonin, N Erkilic, K Damodar, M Clé, C Desmetz, K Bolloré, M Taleb, S Torriano, J Barthelemy, G Dubois, AD Lajoix, V Foulongne, E Tuaillon, P Van de Per, V Kalatzis, S Salinas Zika virus induces strong inflammatory responses and impairs homeostasis and function of the human retinal pigment epithelium EBioMedicine, 2018;0(0):. 2018 [PMID: 30579862] (Human)
• AD Marmorstei, AA Johnson, LA Bachman, C Andrews-Pf, T Knudsen, BJ Gilles, M Hill, JK Gandhi, LY Marmorstei, JS Pulido Mutant Best1 Expression and Impaired Phagocytosis in an iPSC Model of Autosomal Recessive Bestrophinopathy Sci Rep, 2018;8(1):4487. 2018 [PMID: 29540715] (Human)
• H Zhang, Y Xu, H Yue, C Wang, J Gu, J He, W Fu, W Hu, Z Zhang Novel mutations of the SERPINF1 and FKBP10 genes in Chinese families with autosomal recessive osteogenesis imperfecta Int. J. Mol. Med., 2018;0(0):. 2018 [PMID: 29512769] (Human)
• M Eslani, I Putra, X Shen, J Hamouie, N Afsharkham, S Besharat, MI Rosenblatt, R Dana, P Hematti, AR Djalilian Corneal Mesenchymal Stromal Cells Are Directly Antiangiogenic via PEDF and sFLT-1 Invest. Ophthalmol. Vis. Sci., 2017;58(12):5507-5517. 2017 [PMID: 29075761] (Human)
• DA Ferrington, MC Ebeling, RJ Kapphahn, MR Terluk, CR Fisher, JR Polanco, H Roehrich, MM Leary, Z Geng, JR Dutton, SR Montezuma Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration Redox Biol, 2017;13(0):255-265. 2017 [PMID: 28600982] (Human)
• W Shen, B Yau, SR Lee, L Zhu, M Yam, MC Gillies Effects of Ranibizumab and Aflibercept on Human M�ller Cells and Photoreceptors under Stress Conditions Int J Mol Sci, 2017;18(3):. 2017 [PMID: 28257068] (Human)
• Promising Nanocarriers for PEDF Gene Targeting Delivery to Cervical Cancer Cells Mediated by the Over-expressing FR? Sci Rep, 2016;6(0):32427. 2016 [PMID: 27576898] (Mouse)
• McHugh K, Tao S, Saint-Geniez M Porous poly(epsilon-caprolactone) scaffolds for retinal pigment epithelium transplantation. Invest Ophthalmol Vis Sci, 2014;55(3):1754-62. 2014 [PMID: 24550370] (Human)

Bioinformatics

• Gene Symbol: SERPINF1