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HAF016). A specific band was detected for PEDF R/PNPLA2 at approximately 55 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8." class="big_lightbox" target="_blank">
CTS019) and counterstained with hematoxylin (blue). Specific labeling was localized to the plasma membrane of epithelial cells in tubules. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections." class="big_lightbox" target="_blank">
HAF016) . This experiment was conducted under reducing conditions and using the 12-230 kDa separation system." class="big_lightbox" target="_blank">
MAB0041, open histogram), followed by Phy-coerythrin-conjugated Anti-Mouse IgG F(ab')2Secondary Antibody (Catalog # F0102B)." class="big_lightbox" target="_blank">
Patatin-like phospholipase domain-containing protein 2 (PNPLA2), also known as adipose triglyceride lipase (ATGL), is a lipolytic enzyme required for mobilization of fatty acids from triglyceride stores in adipose tissue. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. However, ATGL has now been shown to catalyze the initial step of triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Thus, ATGL and HSL coordinate to catabolize stored triglycerides in adipose tissue of mammals.
Defects in PNPLA2 can lead to neutral lipid storage disease with myopathy (NLSDM), a neutral lipid storage disorder with myopathy but without ichthyosis.
ATGL antibodies can serve as useful tools for adipocyte studies and research on triglyceride processing and fat storage.
![Western Blot PEDFR/PNPLA2/ATGL Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/PEDF_R_AF5365_Western_Blot_5700.jpg)
![Immunohistochemistry PEDFR/PNPLA2/ATGL Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/PEDF_R_AF5365_Immunohistochemistry_6870.jpg)
![Simple Western PEDFR/PNPLA2/ATGL Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/PEDF_R_AF5365_Simple_Western_17547.jpg)
![Western Blot PEDFR/PNPLA2/ATGL Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af5365_human-mouse-rat-pedf-r-pnpla2-affinity-purified-pab-41202412401215.jpg)
![Western Blot PEDFR/PNPLA2/ATGL Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af5365_human-mouse-rat-pedf-r-pnpla2-affinity-purified-pab-western-blot-1212202597183.jpg)
![Western Blot PEDFR/PNPLA2/ATGL Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af5365_human-mouse-rat-pedf-r-pnpla2-affinity-purified-pab-western-blot-12122025914017.jpg)
