PEDFR/PNPLA2/ATGL Products

Description

Patatin-like phospholipase domain-containing protein 2 (PNPLA2), also known as adipose triglyceride lipase (ATGL), is a lipolytic enzyme required for mobilization of fatty acids from triglyceride stores in adipose tissue. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. However, ATGL has now been shown to catalyze the initial step of triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Thus, ATGL and HSL coordinate to catabolize stored triglycerides in adipose tissue of mammals.

Defects in PNPLA2 can lead to neutral lipid storage disease with myopathy (NLSDM), a neutral lipid storage disorder with myopathy but without ichthyosis.

ATGL antibodies can serve as useful tools for adipocyte studies and research on triglyceride processing and fat storage.

Bioinformatics

Entrez	361676 Rat 57104 Human 66853 Mouse
Uniprot	NM_020376 Human NP_005171 Human NP_065109 Human NP_065109.1 Human Q96AD5 Human
Product By Gene ID	57104
Alternate Names	Adipose triglyceride lipase ATGL1110001C14Rik Calcium-independent phospholipase A2 Desnutrin desnutrin EC 3.1.1.3 FP17548 IPLA2-zeta patatin-like phospholipase domain containing 2 patatin-like phospholipase domain-containing protein 2 patatin-like phospholipase domain-containing protein 2-like PEDF-R Pigment epithelium-derived factor Transport-secretion protein 2 transport-secretion protein 2.2 triglyceride hydrolase TTS2.2 TTS-2.2 TTS2DKFZp667M109

Research Areas for PEDFR/PNPLA2/ATGL

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Diabetes Research
Lipid and Metabolism
Lipid Droplets
Signal Transduction