PEDFR/PNPLA2/ATGL Antibody [Alexa Fluor® 405]

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 405

PEDFR/PNPLA2/ATGL Antibody [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant mouse PEDF R/PNPLA2
  Val162-Gly253
  Accession # Q8BJ56
• Specificity: Detects human, mouse, and rat PEDF R/PNPLA2 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PEDFR/PNPLA2/ATGL Antibody [Alexa Fluor® 405]

• Adipose triglyceride lipase
• ATGL
• ATGL1110001C14Rik
• Calcium-independent phospholipase A2
• Desnutrin
• EC 3.1.1.3
• FP17548
• IPLA2-zeta
• patatin-like phospholipase domain containing 2
• patatin-like phospholipase domain-containing protein 2
• patatin-like phospholipase domain-containing protein 2-like
• PEDF R
• PEDFR
• PEDF-R
• Pigment epithelium-derived factor
• PNPLA2
• Transport-secretion protein 2
• transport-secretion protein 2.2
• triglyceride hydrolase
• TTS2
• TTS2.2
• TTS-2.2
• TTS2DKFZp667M109

Background

PEDF R (Pigment epithelium derived factor receptor; also known as ATGL, PNPLA2, and Desnutrin) is a 55 kDa member of the PNPLA family of proteins. It is expressed in adipocytes, hepatocytes, skeletal muscle, and pigment epithelium. PEDF R specifically hydrolyses triglycerides, releasing long-chain fatty acids. Mouse PEDF R is described as being a 486 amino acid (aa) type II transmembrane (TM) protein. Its TM segment is stated to span aa 9-29. Alternatively, it may have a hydrophobic lipid-association domain between aa 267-295. It contains a palatin domain (aa 10-179) with a conserved GxSxG enzymatic motif. There are multiple splice forms. Two show alternate start sites at Met57 and Met232, while two others show a deletion of aa 163-196 and aa 253-308, respectively. Over aa 162-253, mouse PEDF R shares 98% and 93% aa sequence identity with rat and human PEDF R, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.